Tocofersolan
- CAS No.
- 9002-96-4
- Chemical Name:
- Tocofersolan
- Synonyms
- tpgs;VITAMIN E TPGS;Vitamin E polyethylene glycol succinate;d-alpha-tocopheryl polyethylene glycol succinate;Tocophersolan;D-α-Tocopherol polyethylene glycol succinate;tocopherosolan;D-a-Tocopherol Polyethylene Glycol Succinate;d-alpha-tocopherylpoly(ethyleneglycol)1000succinate;D-a-Tocopherol Polyethylene Glycol Succinate (Vitamin E TPGS)
- CBNumber:
- CB8396198
- Molecular Formula:
- (C2H4O)nC33H54O5
- Molecular Weight:
- 0
- MOL File:
- 9002-96-4.mol
- Modify Date:
- 2024/7/26 15:15:06
| Melting point | 34-38°C |
|---|---|
| storage temp. | 2-8°C |
| solubility | H2O: soluble1g/10 mL, clear to faintly turbid, colorless to faintly yellow |
| form | Solid |
| color | White to Pale Yellow Waxy |
| InChI | InChI=1S/C34H56O6/c1-23(2)12-9-13-24(3)14-10-15-25(4)16-11-20-34(8)21-19-29-28(7)32(26(5)27(6)33(29)40-34)39-31(37)18-17-30(36)38-22-35/h23-25,35H,9-22H2,1-8H3 |
| InChIKey | WFWQYXBTWIHIIW-UHFFFAOYSA-N |
| SMILES | C(=O)(OC1C(C)=C2CCC(C)(CCCC(CCCC(CCCC(C)C)C)C)OC2=C(C)C=1C)CCC(=O)OCO |
| LogP | 9.745 (est) |
Tocofersolan price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 57668 | D-α-Tocopherol polyethylene glycol 1000 succinate BioXtra, water soluble vitamin E conjugate | 9002-96-4 | 5G | ₹7869.78 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 57668 | D-α-Tocopherol polyethylene glycol 1000 succinate BioXtra, water soluble vitamin E conjugate | 9002-96-4 | 25G | ₹24139.75 | 2022-06-14 | Buy |
| TCI Chemicals (India) | T3118 | α-Tocopherol Polyethylene Glycol Succinate | 9002-96-4 | 5G | ₹2900 | 2022-05-26 | Buy |
| TCI Chemicals (India) | T3118 | α-Tocopherol Polyethylene Glycol Succinate | 9002-96-4 | 25G | ₹8700 | 2022-05-26 | Buy |
Tocofersolan Chemical Properties,Uses,Production
Chemical Properties
Vitamin E polyethylene glycol succinate is a synthetic product. It is available as a white to light-brown, waxy solid and is practically tasteless. Chemically, it is a mixture composed principally of monoesterified polyethylene glycol 1000, the diesterified polyethylene glycol 1000, free polyethylene glycol 1000, and free tocopherol.
Production Methods
Vitamin E polyethylene glycol succinate is prepared by esterification of the acid group of crystalline D-a-tocopheryl acid succinate by polyethylene glycol 1000.
Pharmaceutical Applications
Vitamin E polyethylene glycol succinate is an esterified vitamin E
(tocopherol) derivative primarily used as a solubilizer or emulsifying
agent because of its surfactant properties. Structurally, it is
amphipathic and hydrophilic, unlike the tocopherols, and therefore
it is a water-soluble derivative that can be used in pharmaceutical
formulations such as capsules, tablets, hot-melt extrusion,
microemulsions, topical products, and parenterals. One of
the most important applications is its use as a vehicle for lipid-based
drug delivery formulations. It can also be used as a source of
vitamin E.
Vitamin E polyethylene glycol succinate has been characterized
with respect to its mechanism of action and studied as a Pglycoprotein
inhibitor.
Safety
Vitamin E polyethylene glycol succinate has been used at levels of 280 mg/capsule in the product Agenerase (amprenavir), which was dosed at 8 capsules (2240mg vitamin E TPGS) per day. An additional assessment of the safety of vitamin E polyethylene glycol succinate has been published, which includes a report showing no-observed-adverse-effect-level (NOAEL) in rats of 1000 mg/kg/day.
storage
Vitamin E polyethylene glycol succinate is stable at ambient room temperature for up to 4 years. It reacts with alkalis and acids. Aqueous solutions of vitamin E polyethylene glycol succinate are stable over a pH range of 4.5–7.5 and can be further stabilized with propylene glycol.
Incompatibilities
Vitamin E polyethylene glycol succinate is incompatible with strong acids and strong alkalis.
Regulatory Status
GRAS listed. Included in the FDA Inactive Ingredients Database (ophthalmic solution or drops; oral capsules, solution, tablet; topical solution or drops). Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Tocofersolan Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Mumbai, India | 66 | 58 | Inquiry |
| BASF India Limited | +91-2262785600 +91-2262785600 | Maharashtra, India | 209 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Matrix Life Science Private Limited | 08048606334 | Maharashtra, India | 4 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Shaanxi LonierHerb Bio Technology Co Ltd | +86-86-+86-86-029-87551862 +8617702909819 | China | 2605 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | China | 12455 | 58 | Inquiry |
| Hebei Guanlang Biotechnology Co,.LTD | +86-19930503253; +8619930503252 | China | 5832 | 58 | Inquiry |