Polyethylene Glycol
- CAS No.
- 25322-68-3
- Chemical Name:
- Polyethylene Glycol
- Synonyms
- PEG;PEO;POLYETHYLENE GLYCOL;PEG 400;POLY(ETHYLENE OXIDE);Macrogol;PEG 6000;PEG-8;PEG-12;PEG-20
- CBNumber:
- CB6145866
- Molecular Formula:
- N/A
- Molecular Weight:
- 0
- MOL File:
- 25322-68-3.mol
- Modify Date:
- 2024/7/2 17:04:22
| Melting point | 64-66 °C |
|---|---|
| Boiling point | >250°C |
| Tg | -67 |
| Density | 1.27 g/mL at 25 °C |
| vapor density | >1 (vs air) |
| vapor pressure | <0.01 mm Hg ( 20 °C) |
| refractive index |
n |
| Flash point | 270 °C |
| storage temp. | 2-8°C |
| solubility | H2O: 50 mg/mL, clear, colorless |
| form | waxy solid |
| Specific Gravity | 1.128 |
| color | White to very pale yellow |
| PH | 5.5-7.0 (25℃, 50mg/mL in H2O) |
| Water Solubility | Soluble in water. |
| Sensitive | Hygroscopic |
| λmax |
λ: 260 nm Amax: 0.6 λ: 280 nm Amax: 0.3 |
| Merck | 14,7568 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| LogP | -0.698 at 25℃ |
| NIST Chemistry Reference | Polyethylene glycol(25322-68-3) |
| EPA Substance Registry System | Polyethylene glycol (25322-68-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS06,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H311-H373-H411 | |||||||||
| Precautionary statements | P273-P280-P301+P312+P330-P302+P352+P312-P391-P501 | |||||||||
| Hazard Codes | Xi,T | |||||||||
| Risk Statements | 36/38-52/53-33-23/24/25 | |||||||||
| Safety Statements | 26-36-24/25-61-45-36/37 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TQ4110000 | |||||||||
| F | 3-9 | |||||||||
| Autoignition Temperature | 581 °F | |||||||||
| Hazard Note | Harmful | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 39072011 | |||||||||
| Toxicity | LD50 orally in Rabbit: 28000 mg/kg LD50 dermal Rabbit > 20000 mg/kg | |||||||||
| NFPA 704 |
|
Polyethylene Glycol price More Price(306)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR3338 | Polyethylene Glycol 600 certified reference material, pharmaceutical secondary standard | 25322-68-3 | 1G | ₹17038.55 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR3337 | Polyethylene Glycol 3000 certified reference material, pharmaceutical secondary standard | 25322-68-3 | 1G | ₹17471.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR3336 | Polyethylene Glycol 300 certified reference material, pharmaceutical secondary standard | 25322-68-3 | 1G | ₹17038.55 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR3335 | Polyethylene Glycol 200 certified reference material, pharmaceutical secondary standard | 25322-68-3 | 1G | ₹17038.55 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR3334 | Polyethylene Glycol 1500 certified reference material, pharmaceutical secondary standard | 25322-68-3 | 1G | ₹17471.4 | 2022-06-14 | Buy |
Polyethylene Glycol Chemical Properties,Uses,Production
Description
Polyethylene glycols are a family of linear polymers formed by a base-catalyzed condensation reaction with repeating ethylene oxide units being added to ethylene. The molecular formula is (C2H4O)multH2O where mult denotes the average number of oxyethylene groups. The molecular weight can range from 200 to several million corresponding to the number of oxyethylene groups. The higher-molecular-weight materials (100 000 to 5 000 000) are also referred to as polyethylene oxides. The average molecular weight of any specific polyethylene glycol product falls within quite narrow limits (°5%). The number of ethylene oxide units or their approximate molecular weight (e.g., PEG-4 or PEG-200) commonly designates the nomenclature of specific polyethylene glycols. Polyethylene glycols with amolecular weight less than 600 are liquid, whereas those of molecular weight 1000 and above are solid. These materials are nonvolatile, water-soluble, tasteless, and odorless. They are miscible with water, alcohols, esters, ketones, aromatic solvents, and chlorinated hydrocarbons, but immiscible with alkanes, paraffins, waxes, and ethers.
Chemical Properties
White waxy crystalline flakes
Uses
Used in conjunction with carbon black to form a conductive composite.1 Polymer nanospheres of poly(ethylene glycol) were used for drug delivery.2
Indications
Polyethylene glycol (Miralax) is another osmotic laxative that is colorless and tasteless once it is mixed.
Production Methods
Polyethylene glycol polymers are formed by the reaction of ethylene oxide and water under pressure in the presence of a catalyst.
Definition
Any of several condensa-tion polymers of ethylene glycol with thegeneral formula HOCH2(CH2OCH2)nCH2OH orH(OCH2CH2)nOH. Average molecular weightsrange from 200 to 6000. Properties vary with molec-ular weight.
General Description
Clear colorless viscous liquid.
Air & Water Reactions
Water soluble.
Reactivity Profile
Poly(ethylene glycol) is heat-stable and inert to many chemical agents; Poly(ethylene glycol) will not hydrolyze or deteriorate under normal conditions. Poly(ethylene glycol) has a solvent action on some plastics.
Fire Hazard
Poly(ethylene glycol) is combustible.
Safety Profile
When heated to decomposition it emits acrid smoke and irritating fumes.
Environmental Fate
Like other polymeric substances, polyethylene glycols are not readily biodegradable, with reported 5-day biochemical oxygen demand (BOD5) of 0–1%. However, owing to their hydrophilicity, they have a low potential to bioaccumulate.
storage
Polyethylene glycols are chemically stable in air and in solution, although grades with a molecular weight less than 2000 are hygroscopic. Polyethylene glycols do not support microbial growth, and they do not become rancid.
Polyethylene glycols and aqueous polyethylene glycol solutions can be sterilized by autoclaving, filtration, or gamma irradiation.
Sterilization of solid grades by dry heat at 150℃ for 1 hour may induce oxidation, darkening, and the formation of acidic degradation products. Ideally, sterilization should be carried out in an inert atmosphere. Oxidation of polyethylene glycols may also be inhibited by the inclusion of a suitable antioxidant.
If heated tanks are used to maintain normally solid polyethylene glycols in a molten state, care must be taken to avoid contamination with iron, which can lead to discoloration. The temperature must be kept to the minimum necessary to ensure fluidity; oxidation may occur if polyethylene glycols are exposed for long periods to temperatures exceeding 50℃. However, storage under nitrogen reduces the possibility of oxidation.
Polyethylene glycols should be stored in well-closed containers in a cool, dry place. Stainless steel, aluminum, glass, or lined steel containers are preferred for the storage of liquid grades.
Incompatibilities
The chemical reactivity of polyethylene glycols is mainly confined to
the two terminal hydroxyl groups, which can be either esterified or
etherified. However, all grades can exhibit some oxidizing activity
owing to the presence of peroxide impurities and secondary
products formed by autoxidation.
Liquid and solid polyethylene glycol grades may be incompatible
with some coloring agents.
The antibacterial activity of certain antibiotics is reduced in
polyethylene glycol bases, particularly that of penicillin and
bacitracin. The preservative efficacy of the parabens may also be
impaired owing to binding with polyethylene glycols.
Physical effects caused by polyethylene glycol bases include
softening and liquefaction in mixtures with phenol, tannic acid, and
salicylic acid. Discoloration of sulfonamides and dithranol can also
occur, and sorbitol may be precipitated from mixtures. Plastics, such
as polyethylene, phenolformaldehyde, polyvinyl chloride, and cellulose-ester membranes (in filters) may be softened or dissolved
by polyethylene glycols. Migration of polyethylene glycol can occur
from tablet film coatings, leading to interaction with core
components.
Regulatory Status
Included in the FDA Inactive Ingredients Database (dental preparations; IM and IV injections; ophthalmic preparations; oral capsules, solutions, syrups, and tablets; rectal, topical, and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Polyethylene Glycol Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
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chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Mumbai, India | 66 | 58 | Inquiry |
| Vardhaman P Golechha | 9704422000 | Telangana, India | 294 | 58 | Inquiry |
| Atul Intermediates | +91-7940399111 +91-9825071644 | Gujarat, India | 24 | 58 | Inquiry |
| Nyne Organics Pvt Ltd | +91-9920180386 +91-9920180386 | Mumbai, India | 53 | 58 | Inquiry |
| VA SUDHA Chemicals Private Limited | +91-9653313056 +91-9653313056 | Maharashtra, India | 8 | 58 | Inquiry |
| Shreenath Chemicals | +91-8369634120 +91-8369634120 | Maharashtra, India | 48 | 58 | Inquiry |
| UNILOSA INTERNATINAL PRIVATE LIMITED | +91-9999069917 +91-9999069917 | New Delhi, India | 152 | 58 | Inquiry |
| Akhil Healthcare Pvt Ltd | +91-8097372415 +91-8097372415 | Mumbai, India | 15 | 58 | Inquiry |
| Choice Chemicals | +91-9895031268 +91-9895031268 | Kerela, India | 118 | 58 | Inquiry |
| Viswaat Chemicals Limited | +91-7208827711 +91-8291300373 | Mumbai, India | 63 | 58 | Inquiry |
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