Polyoxyethylene stearate
- CAS No.
- 9004-99-3
- Chemical Name:
- Polyoxyethylene stearate
- Synonyms
- PEG-100 STEARATE;Polyethylene glycol monostearate;PEG-75 STEARATE;POES;polyoxyl;polystate;PEG-150 STEARATE;POLYOXYL 50 STEARATE;POLYOXYETHYLENE 8 STEARATE;Polyoxyl 100 Stearate (200 mg)
- CBNumber:
- CB4111623
- Molecular Formula:
- C34H70O9
- Molecular Weight:
- 622.91
- MOL File:
- 9004-99-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/2 11:02:32
| Melting point | 47 °C |
|---|---|
| Flash point | 39 °C |
| storage temp. | 2-8°C |
| Water Solubility | Soluble in water |
| solubility | Chloroform (Slighty), Methanol (Slightly) |
| form | powder to lump |
| color | White to Almost white |
| Odor | at 100.00?%. mild fatty |
| Hydrophilic-Lipophilic Balance (HLB) | 18.8 |
| LogP | 7.629 (est) |
| EPA Substance Registry System | Polyethylene glycol monostearate (9004-99-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | MD0907300 | |||||||||
| HS Code | 3907200000 | |||||||||
| Toxicity | LD50 oral in rabbit: > 12mL/kg | |||||||||
| NFPA 704 |
|
Polyoxyethylene stearate price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | P3440 | Polyoxyethylene (40) stearate | 9004-99-3 | 250G | ₹3474.3 | 2022-06-14 | Buy |
| TCI Chemicals (India) | P0723 | Polyethylene Glycol Monostearate (n=approx. 55) (palmitate and stearate mixture) | 9004-99-3 | 25G | ₹1800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | P0723 | Polyethylene Glycol Monostearate (n=approx. 55) (palmitate and stearate mixture) | 9004-99-3 | 500G | ₹4200 | 2022-05-26 | Buy |
| TCI Chemicals (India) | P0722 | Polyethylene Glycol Monostearate (n=approx. 45) (palmitate and stearate mixture) | 9004-99-3 | 25G | ₹2000 | 2022-05-26 | Buy |
| TCI Chemicals (India) | P0722 | Polyethylene Glycol Monostearate (n=approx. 45) (palmitate and stearate mixture) | 9004-99-3 | 500G | ₹5200 | 2022-05-26 | Buy |
Polyoxyethylene stearate Chemical Properties,Uses,Production
Chemical Properties
Waxy, light-tan solid; nearly odorless. Congealing range 39–45C. Soluble in water, alcohol, ether, and acetone; insoluble in mineral and vegetable oils.
Uses
Polyoxyethylene stearate is an emulsifier and antifoaming agent used in processed foods, fruit jellies, and sauces.
Uses
Pegosperse(R) 1500 MS is a mixture of polyethylene glycol esters. It is compatible with lipophilic compounds due to a higher free fatty acid content. Suggested applications: cosmetic formulations, lubricants.
Pegosperse(R) 1750 MS is a high molecular weight, high HLB surface active agent suggested for use in cosmetic formulations (emulsifier, viscosity modifier) and lubricants (emulsifier).
Pegosperse(R) 400 MS is a multifunctional surface active agent suggested for use in cosmetic formulations, household products, lubricants, textile chemicals, polishes and paper.
PEG-5 stearate, an emulsifier, is listed as particularly applicable for hand and body lotions and creams.
Definition
Polyoxyethylene stearate is a mixture of the monoand diesters of stearic acid and mixed polyoxyethylene diols having an average polymer length of 7.5 oxyethylene units.
General Description
Polyoxyethylene (40) stearate is a neutral surfactant.
Safety Profile
Very slightly toxic by ingestion. Questionable carcinogen with experimental tumorigenic data. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes. See also other polyethylene glycol monostearate entries and POLYETHYLENE GLYCOL.
in vitro
Polyoxyethylene stearate has been recommended as an additive to the radiolabelled 7H12 Middlebrook TB media and, as such, has been shown to enhance the growth of mycobacteria in the radiometric BACTEC rapid culture system. Polyoxyethylene (50) stearate produces the greatest enhancement in growth and reduction in the time taken to detect growth for M. tuberculosis and polyoxyethylene (30) stearate and polyoxyethylene (JL) stearate for species of mycobacteria other than M. tuberculosis. Polyoxyethylene stearate inhibits P-gp mediated efflux in a concentration-dependent manner mainly by modulating substrate-stimulated P-gp ATPase activity. Polyoxyethylene 40 stearate reduces vinblastine sulfate efllux. The cytotoxicity of vinblastine to K562/ADR cells is significantly enhanced when cotreated with 100 or 150 μg/mL polyoxyethylene 40 stearate.
in vivo
Polyoxyethylene stearate is potentially useful as a pharmaceutical ingredient to improve the oral bioavailability of coadministered P-gp substrates and substrates for certain CYP isoforms. The average tumour volume and weight are significantly less in the polyoxyethylene 40 stearate+vinblastine groups. The inhibition rate for tumor growth is increased from 0.06 (vinblastine group) to 0.84 (vinblastine+polyoxyethylene 40 stearate group).
Polyoxyethylene stearate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Viswaat Chemicals Limited | +91-7208827711 +91-8291300373 | Mumbai, India | 63 | 58 | Inquiry |
| Arihant Innochem Pvt Ltd | +91-2267674895 +91-2267674895 | Mumbai, India | 37 | 58 | Inquiry |
| TRUUCHEM TECHNOLOGIES PRIVATE LIMITED | +91-8619349510 +91-8619349510 | Bangalore, India | 82 | 58 | Inquiry |
| Planet Science (Quality Excipients) | 91-22-21581500 | Maharashtra, India | 55 | 58 | Inquiry |
| Esteem Industries Private Limited | 91-832-6613333 | GOA, India | 36 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| S. V. Enterprises | 08048968192 | Mumbai, India | 35 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| World Chem Industries | 08048361314Ext 857 | Gujarat, India | 8 | 58 | Inquiry |
| Lexine Technochem Private Limited | 07942564658 | Vadodara, India | 69 | 58 | Inquiry |