1,2-Dibromoethane
- CAS No.
- 106-93-4
- Chemical Name:
- 1,2-Dibromoethane
- Synonyms
- EDB;DIBROMOETHANE;ETHYLENE DIBROMIDE;1,2-dibromethane;1,2-EDB;1,2-Dibromethan;1,2-DIBROMOETANE;ETHYLENE BROMIDE;Soilbrom;CH2BrCH2Br
- CBNumber:
- CB6852689
- Molecular Formula:
- C2H4Br2
- Molecular Weight:
- 187.86
- MOL File:
- 106-93-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/26 17:49:17
| Melting point | 9 °C |
|---|---|
| Boiling point | 131-132 °C(lit.) |
| Density | 2.18 g/mL at 25 °C(lit.) |
| vapor density | ~6.5 (vs air) |
| vapor pressure | 11.7 mm Hg ( 25 °C) |
| refractive index |
n |
| Flash point | 132°C |
| storage temp. | 0-6°C |
| solubility | water: soluble250 part |
| form | Liquid |
| color | Clear colorless to pale yellow |
| Odor | Mild, sweet odor detectable at 10 ppm |
| Odor Threshold | 10 ppm |
| Water Solubility | 4 g/L (20 ºC) |
| Sensitive | Light Sensitive |
| Merck | 14,3796 |
| BRN | 605266 |
| Henry's Law Constant | 7.58(x 10-4 atm?m3/mol) at 25 °C (static headspace-GC, Welke et al., 1998) |
| Dielectric constant | 4.75 |
| Exposure limits | NIOSH REL: TWA 0.045 ppm, 15-min C 0.13 ppm, IDLH 100 ppm; OSHA PEL: TWA 20 ppm, C 30 ppm, 5-min peak 50 ppm;ACGIH TLV: suspected human carcinogen. |
| Stability | Stable, but may be light sensitive. Incompatible with strong oxidizing agents, magnesium, alkali metals. |
| CAS DataBase Reference | 106-93-4(CAS DataBase Reference) |
| IARC | 2A (Vol. 15, Sup 7, 71) 1999 |
| NIST Chemistry Reference | Ethane, 1,2-dibromo-(106-93-4) |
| EPA Substance Registry System | Ethylene dibromide (106-93-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS06,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301+H311+H331-H315-H319-H335-H350-H411 | |||||||||
| Precautionary statements | P273-P280-P301+P310-P302+P352+P312-P304+P340+P311-P305+P351+P338 | |||||||||
| Hazard Codes | T,N,F | |||||||||
| Risk Statements | 45-23/24/25-36/37/38-51/53-34-39/23/24/25-11 | |||||||||
| Safety Statements | 53-45-61-36/37/39-26-36/37-16-7 | |||||||||
| RIDADR | UN 1605 6.1/PG 1 | |||||||||
| OEB | E | |||||||||
| OEL | TWA: 0.045 ppm, Ceiling: 0.13 ppm [15-minute] | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | KH9275000 | |||||||||
| F | 8 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | I | |||||||||
| HS Code | 29337100 | |||||||||
| Toxicity | LD50 i.p. in mice: 220 mg/kg (Fischer) | |||||||||
| IDLA | 46 ppm (354 mg/m3) | |||||||||
| NFPA 704 |
|
1,2-Dibromoethane price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 48880-U | 1,2-Dibromoethane solution certified reference material, 200?μg/mL in methanol | 106-93-4 | 1ML | ₹3418.1 | 2022-06-14 | Buy |
| ALFA India | ALF-A12766-30 | 1,2-Dibromoethane, 99% | 106-93-4 | 250g | ₹4219 | 2022-05-26 | Buy |
| ALFA India | ALF-A12766-0B | 1,2-Dibromoethane, 99% | 106-93-4 | 1000g | ₹6136 | 2022-05-26 | Buy |
| ottokemi | D 1457 | 1,2-Dibromoethane, puriss 99%+ 99%+ | 106-93-4 | 250ML | ₹11709 | 2022-05-26 | Buy |
| ottokemi | D 1455 | 1,2-Dibromoethane 98% | 106-93-4 | 250ML | ₹1593 | 2022-05-26 | Buy |
1,2-Dibromoethane Chemical Properties,Uses,Production
Chemical Properties
1,2-Dibromoethane is a colorless nonflammable liquid with a mild sweet odor, like chloroform. The minimum concentration detectable by odor is 10 ppm.It is stable at room temperature, but can be slowly decomposed into toxic substances under light. It is miscible with ethanol, ether, carbon tetrachloride, benzene, gasoline and other organic solvents, and forms azeotropes, and dissolves in about 250 times of water. Noncombustible. Very toxic by inhalation, skin absorption or ingestion. used as a solvent, scavenger for lead in gasoline, grain fumigant and in the manufacture of other chemicals.
Physical properties
Colorless liquid with a sweet, chloroform-like odor. Odor threshold concentration is 25 ppb (quoted, Keith and Walters, 1992).
Uses
1,2-Dibromoethane (EDB) is used as a fumigant for grains, in antiknock gasolines, as asolvent, and in organic synthesis. Most of the uses of 1,2-dibromoethane have been stopped in the United States; however, it is still used as a fumigant for treatment of logs for termites and beetles, for the control of moths and beehives, and as a preparation for dyes and waxes.
Definition
ChEBI: 1,2-dibromoethane is a bromoalkane that is ethane carrying bromo substituents at positions 1 and 2. It is produced by marine algae. It has a role as a fumigant, a carcinogenic agent, a marine metabolite, an algal metabolite, a mouse metabolite and a mutagen. It is a bromohydrocarbon and a bromoalkane.
Preparation
1,2-Dibromoethane is manufactured via uncatalyzed, liquid-phase bromination of ethylene. Gaseous ethylene is brought into contact with bromine by various methods, allowing for dissipation of the heat of the reaction.
General Description
1,2-dibromomethane is a heavy, colourless liquid with a mild sweet odour, like chloroform. Ethylene dibromide is incompatible with strong oxidisers, magnesium, alkali metals, and liquid ammonia. Ethylene dibromide is soluble in alcohols, ethers, acetone, benzene, and most organic solvents and slightly soluble in water. It reacts with lead residues to generate volatile lead bromides. Because of limitations in epidemiological study evidences for ethylene dibromide as a human carcinogen is inconclusive. In 1984, the U.S. EPA imposed a ban on its use as a soil and grain fumigant.
Air & Water Reactions
Slightly soluble in water. May react slowly with moisture.
Reactivity Profile
1,2-Dibromoethane slowly decomposes in the presence of light and heat. Turns brown upon exposure to light. Corrosive to iron and other metals. May decompose upon contact with alkalis. Incompatible with oxidizing agents. Reacts with sodium, potassium, calcium, powdered aluminum, zinc, magnesium and liquid ammonia. May attack some plastics, rubber and coatings. May poison platinum catalysts [Hawley]. Reacts as an alkylating agent .
Hazard
Probable carcinogen. Toxic by inhalation, ingestion, and skin absorption; strong irritant to eyes and skin.
Health Hazard
1,2-Dibromoethane is toxic by inhalation,ingestion, or skin contact. The acute toxicsymptoms are depression of the central ner vous system, irritation and congestion oflungs, hepatitis, and renal damage. Chronicexposure can produce conjunctivitis, bron chial irritation, headache, depression, lossof appetite, and loss of weight. Recoveryoccurs after cessation of exposure. Prolongedor repeated exposures to high concentrationscan be fatal to animals and humans. Lethalconcentration for a 2-hour exposure period is400 ppm in rats.
1,2-Dibromoethane is moderate to highlytoxic by ingestion. Its toxicity is far greaterthan that of 1,2-dichloroethane. An oralintake of 5 to 10 mL of the liquid can be fatalto humans. Death occurs from necrosis of theliver and kidney damage. The oral LD50 val ues varied between 50 and 125 mg/kg fordifferent species of laboratory animals.
Vapors are irritant to the eyes. Contactwith the liquid can damage vision. Skincontact may produce severe irritation andblistering.
Mutagenic tests were positive, while thehistidine reversion–Ames test gave incon clusive results (NIOSH 1986). 1,2-Dibromo ethane is carcinogenic to animals and issuspected to cause cancer in humans. Inhala tion of this compound produced tumors inthe lungs and nose in mice and rats. Oraladministration caused cancers in the liver andgastrointestinal tract.
Flammability and Explosibility
Ethylene dibromide is a noncombustible substance (NFPA rating = 0).
Agricultural Uses
Fumigant, Nematicide: Not approved for use in EU countries. Not registered for use in the U.S. Persons whose clothing or skin is contaminated with liquid ethylene dibromide (above 10°C) can secondarily contaminate others by direct contact or through off-gassing vapor. Ethylene dibromide was used extensively as a pesticide and an ingredient of soil, vegetable, fruit, and grain fumigant formulations. Still used in India, South Africa and other countries. There are 15 global suppliers.
Trade name
AADIBROOM®; EDB-85; FUMO-GAS®; ISCOBROME D®; KOPFUME®; NEFIS®; NEPHIS®; SOILFUME®; UNIFUME®
Safety Profile
Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and teratogenic data. Human poison by ingestion. Experimental poison by ingestion, sktn contact, intraperitoneal, and possibly other routes. Moderately toxic by inhalation and rectal routes. Human systemic effects by ingestion: hypermothty, barrhea, nausea or vomiting, decreased urine volume or anuria. Experimental reproductive effects. Human mutation data reported. A severe skin and eye irritant. Implicated in worker sterdity. When heated to decomposition it emits toxic fumes of Br-. See also ETHYLENE DICHLORIDE and BROMIDES.
Potential Exposure
Ethylene dibromide is used as a chemical intermediate; as a fumigant for ground pest control; as a constituent of ethyl gasoline (anti-knock agent). It is also used in fire extinguishers, gauge fluids, and waterproofing preparations; and it is used as a solvent for celluloid, fats, oils, and waxes. Pesticide not in use; TRI and/or IUR indicates importers or manufacturers are unlikely
Carcinogenicity
1,2-Dibromoethane is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
Cancer Studies in Experimental Animals
Metabolic pathway
The bacterial strain GP1 can utilize 1,2-dibromoethane as a sole carbon and energy source. The first step in 1,2-dibromoethane is catalyzed by a hydrolytic haloalkane dehalogenase and the resulting 2- bromoethanol is rapidly converted to ethylene oxide, preventing the accumulation of 2-bromoethanol and 2- bromoacetaldehyde. However, the further metabolic pathway(s) is unclear.
storage
work with EDB should be conducted in a fume hood to prevent exposure by inhalation, and appropriate impermeable gloves and safety goggles should be worn to prevent skin contact. Gloves and protective clothing should be changed immediately if EDB contamination occurs. Since EDB can penetrate neoprene and other plastics, protective apparel made of these materials does not provide adequate protection from contact with EDB.
Shipping
UN1605/154 Ethylene dibromide, Hazard Class: 6.1; Labels: 6.1-Poison Inhalation Hazard, Inhalation Hazard Zone B
Purification Methods
Wash the dibromide with conc HCl or H2SO4, then water, aqueous NaHCO3 or Na2CO3, more water, and dry it with CaCl2. Fractionally distil it. Alternatively, keep in daylight with excess bromine for 2hours, then extract with aqueous Na2SO3, wash with water, dry with CaCl2, filter and distil. It can also be purified by fractional crystallisation by partial freezing. Store it in the dark. [Beilstein 1 H 90, 1 I 28, 1 II 61, 1 III 182, 1 IV 158.]
Incompatibilities
Reacts vigorously with chemically active metals; liquid ammonia, strong bases; strong oxidizers; causing fire and explosion hazard. Light, heat, and moisture can cause slow decomposition, forming hydrogen bromide. Attacks fats, rubber, some plastics and coatings.
Waste Disposal
Controlled incineration with adequate scrubbing and ash disposal facilities
1,2-Dibromoethane Preparation Products And Raw materials
Raw materials
Preparation Products
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chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| PACIFIC ORGANICS PVT LTD | +91 9322467890 | Maharashtra, India | 51 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| SHRI LAXMI CHEMICALS | +91-7046525088 +91-8200315284 | Ahmedabad, India | 45 | 58 | Inquiry |
| Bhavika Chemicals Corporation | +91-9867153307 +91-9867153307 | Maharashtra, India | 31 | 58 | Inquiry |
| Neogen Chemicals Ltd | +91-9619496467 +91-8657984687 | Maharashtra, India | 56 | 58 | Inquiry |
| Brom India | +91-9920046827 +91-9920046827 | Maharashtra, India | 23 | 58 | Inquiry |
| Faluck International | +91-7922705556 +91-9825549375 | Gujarat, India | 42 | 58 | Inquiry |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | +91-26463395 +91-7926462688 | Gujarat, India | 1615 | 58 | Inquiry |
| Dhruv Chem Industries | +91-9925680760 +91-9328188755 | Gujarat, India | 32 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| GLR Innovations | 58 |
| PACIFIC ORGANICS PVT LTD | 58 |
| JSK Chemicals | 58 |
| SHRI LAXMI CHEMICALS | 58 |
| Bhavika Chemicals Corporation | 58 |
| Neogen Chemicals Ltd | 58 |
| Brom India | 58 |
| Faluck International | 58 |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | 58 |
| Dhruv Chem Industries | 58 |
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