Menatetrenone
- CAS No.
- 863-61-6
- Chemical Name:
- Menatetrenone
- Synonyms
- Vitamin K2;MENAQUINONE;e3100;D00100;Glakay;kaytwo;mk(sub4);k2(sub20);Metetrenone;Vitamine K2
- CBNumber:
- CB2471321
- Molecular Formula:
- C31H40O2
- Molecular Weight:
- 444.65
- MOL File:
- 863-61-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:03
| Melting point | 350C |
|---|---|
| Boiling point | 494.59°C (rough estimate) |
| Density | 1.0461 (rough estimate) |
| refractive index | 1.5045 (estimate) |
| Flash point | 2℃ |
| storage temp. | -20°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly, Heated) |
| form | Solid |
| color | Light Yellow to Yellow Oil |
| InChIKey | DKHGMERMDICWDU-GHDNBGIDSA-N |
| CAS DataBase Reference | 863-61-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H225-H302+H312+H332-H319 |
| Precautionary statements | P210-P280-P305+P351+P338 |
| Safety Statements | 22-24/25 |
| RIDADR | UN 1648 3 / PGII |
| WGK Germany | 3 |
| RTECS | QL9279500 |
| HS Code | 2914699000 |
| Toxicity | LD50 intravenous in dog: > 40mL/kg |
Menatetrenone price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | V9378 | Vitamin K2 | 863-61-6 | 250MG | ₹10684.28 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | V9378 | Vitamin K2 | 863-61-6 | 1G | ₹29703.8 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | V-031 | Vitamin K2 (MK-4) solution 100?μg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant? | 863-61-6 | 1ML | ₹10543.55 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 47774 | Menaquinone (K2) analytical standard | 863-61-6 | 100MG | ₹5758.9 | 2022-06-14 | Buy |
Menatetrenone Chemical Properties,Uses,Production
Description
Menatetrenone (also known as MK-4) is a manaquinone compound and a vitamin K compound which can be used as a hemostatic agent as well as adjunctive therapy for the pain of osteoporosis. It mainly takes effects through modulating the signaling of certain tyrosine kinases, thereby affecting several transcription factors including c-myc and c-fos. It is capable of inhibiting tumor cells growth through inducing apoptosis and cell cycle arrest. It can be produced via the conversion of vitamin K1 inside the body including the testes, pancreas and arterial walls.
Chemical Properties
A yellow crystal is extracted from acetone-ethanol or methanol-chloroform. It has a molecular weight of 580.90 and a melting point of 51-52°C. It is insoluble in water but slightly soluble in oil. It dissolves well in ethanol, ether, acetone, benzene, chloroform, and other organic solvents. However, its solubility is slightly lower than that of vitamin K1. It decomposes when exposed to strong acid, oxidants, alkalis, and light.
Occurrence
Menatetrenone (vitamin K2) is widely found in green leaves and vegetables, and also in fish, meat, cheese and liver oil.
Definition
ChEBI: Menaquinone-4 is a menaquinone whose side-chain contains 4 isoprene units in an all-trans-configuration. It has a role as a bone density conservation agent, a human metabolite, an antioxidant, an anti-inflammatory agent and a neuroprotective agent.
Preparation
It can be extracted from millet leaves and rotten fish, and can also be synthesized with 2-menaquinone-1,4.
General Description
Menaquinone (K2), a vitamin K2 homologue with four isoprene units. It has been reported to enhance bone formation and plays a vital role in the production of blood coagulation factors.
References
https://pubchem.ncbi.nlm.nih.gov/compound/menatetrenone#section=Biomolecular-Interactions-and-Pathways
https://en.wikipedia.org/wiki/Menatetrenone
Menatetrenone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Anthem Biosciences Pvt Ltd | +91-8066724000 +91-9900044575 | Karnataka, India | 38 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Sanovi Pharmaceuticals Pvt Ltd | +91-9900284769 +91-9900284769 | Karnataka, India | 42 | 58 | Inquiry |
| Nakoda Chemicals Ltd | +91-9848218200 +91-9848218200 | Telangana, India | 15 | 58 | Inquiry |
| Medilink Pharmachem | +91 (79) 3007-0133 | New Delhi, India | 424 | 50 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Astitva Chemicals | 08048262675 | Gujarat, India | 90 | 58 | Inquiry |
| Triveni Interchem Private Limited (Group Of Triveni... | 08046042087 | Gujarat, India | 497 | 58 | Inquiry |
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