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Paricalcitol

CAS No.: 131918-61-1

Chemical Name:: Paricalcitol

Synonyms: Zemplar;CS-1390;Zemplarr;PARICALCITOL;Paricalciferol;Paricalcitol, >=98%;Paricalcitol(Zemplar);19-Nor-1,25- dihydroxyvitaMin D2;1α,25-Dihydroxy-19-nor-vitaMin D2;19-nor-1alpha,25-dihydroxyvitamin D2

CBNumber:: CB0500520

Molecular Formula:: C27H44O3

Molecular Weight:: 416.65

MOL File:: 131918-61-1.mol

MSDS File:: SDS

Modify Date:: 2024/7/2 8:54:58

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Paricalcitol Properties

Boiling point	564.8±50.0 °C(Predicted)
Density	1.121±0.06 g/cm3(Predicted)
Flash point	14℃
storage temp.	Store at -20°C,unstable in solution, ready to use.
solubility	DMSO : 100 mg/mL (240.02 mM; Need ultrasonic)Ethanol : 12.5 mg/mL (30.00 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
pka	14.34±0.40(Predicted)
form	Solid
color	White to off-white
InChIKey	BPKAHTKRCLCHEA-UBFJEZKGSA-N
SMILES	C[C@]12CCC/C(=C\C=C3C[C@@H](O)C[C@H](O)C3)/[C@]1([H])CC[C@]2([H])[C@H](C)/C=C/[C@H](C)C(O)(C)C \|&1:1,10,13,16,20,22,26,r\|
CAS DataBase Reference	131918-61-1(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS08

Signal word

Danger

Hazard statements

H301+H311-H330-H372

Precautionary statements

P280-P301+P310+P330-P302+P352+P312-P304+P340+P310-P314

RIDADR

UN1170 - class 3 - PG 2 - Ethanol, solution

HS Code

2936299055

NFPA 704

	0
4		0

Paricalcitol Chemical Properties,Uses,Production

Description

Paricalcitol was launched as Zemplar in the US for the prevention and treatment of secondary hyperthyroidism associated with chronic renal failure. Paricalcitol is a synthetic vitamin D2, namely a novel 1-alpha-hydroxy-19-noranalogue in which the ring A exocyclic methylene group, typical of all vitamin D systems, has been replaced by two hydrogen atoms. Paricalcitol is the first vitamin D analogue marketed for this indication. In patients with chronic renal failure, Paricalcitol appreciably reduced levels of parathyroid hormone (PTH) without a significant difference in the incidence rate for hypercalcemia or hyperphosphatemia when compared with placebo.

Chemical Properties

White Solid

Uses

1,25-Dihydroxy vitamin D2 is a potent agonist of the vitamin D receptor. Paricalcitol is a synthetic 1,25-dihydroxy vitamin D2 analog. As vitamin D deficiency, associated with chronic kidney disease, leads to an increase in parathyroid hormone (secondary hyperparathyroidism), paricalcitol is used in renal patients to block parathyroid hormone overproduction. Vitamin D deficiency is also a risk factor in cancer, cardiovascular disease, hypertension, and diabetes, and paricalcitol may have applications in those contexts as well.

Paricalcitol Preparation Products And Raw materials

Raw materials

Preparation Products

Paricalcitol Suppliers

Global( 259)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Dishman Carbogen Amcis Ltd (Dishman Group)	+91-2717420100 +91-8154017093	Gujarat, India	90	58	Inquiry
EAGLE CHEMICAL WORKS	+91-22263303652226330365 +91-2226330365	Maharashtra, India	61	58	Inquiry
Sai Life Sciences Ltd	+91-4066777555 +91-8008555365	Hyderabad, India	24	58	Inquiry
Hetero Drugs Limited	+91-4023704923 +91-4023704923	Telangana, India	296	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6522	58	Inquiry
Sai Life Sciences Ltd.	08048372046Ext 374	Hyderabad, India	9	58	Inquiry
Mahalaxmi Chemi Pharma	08066085774Ext 394	Mumbai, India	11	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
NEULAND LABORATORIES LTD	+91 40 67611600 / 1700	New Delhi, India	55	58	Inquiry

Supplier	Advantage
Dishman Carbogen Amcis Ltd (Dishman Group)	58
EAGLE CHEMICAL WORKS	58
Sai Life Sciences Ltd	58
Hetero Drugs Limited	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
SynZeal Research Pvt Ltd	58
Sai Life Sciences Ltd.	58
Mahalaxmi Chemi Pharma	58
CLEARSYNTH LABS LTD.	58
NEULAND LABORATORIES LTD	58

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Paricalcitol Solution Paricalcitol 1(ALPHA) 25-DIHYDROXYVITAMIN D2*

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1α,25-Dihydroxy-19-nor-vitaMin D2 Paricalcitol/ 19-nor-1α,25-dihydroxyergocalciferol PARICALCITOL (10 MG)F0E3030.997MG/MG(AI) PARICALCITOL 19-nor-1alpha,25-dihydroxyvitamin D2 (1R,3R)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5S)-6-Hydroxy-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]cyclohexane-1,3-diol 1,3-Cyclohexanediol, 5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,2E,4S)-5-hydroxy-1,4,5-trimethyl-2-hexen-1-yl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,3R,5Z)- Paricalcitol, >=98% 1,25-DihydroxyvitaMin D2 Paricalcitol Paricalcitol(Zemplar) Paricalcitol (10 mg) (COLD SHIPMENT REQUIRED) (1R,3R,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-Octahydro-1-[(1R,2E,4S)-5-hydroxy-1,4,5-triMethyl-2-hexen-1-yl]-7a-Methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol (1α,3β,7E,22E)-19-Nor-9,10-secoergosta-5,7,22-triene-1,3,25-triol 19-Nor-1,25- dihydroxyvitaMin D2 (1R,3R)-5-(2-((1R,3aS,7aR,E)-1-((2R,5S,E)-6-hydroxy-5,6-dimethylhept-3-en-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)cyclohexane-1,3-diol ParicalcitolQ: What is Paricalcitol Q: What is the CAS Number of Paricalcitol Q: What is the storage condition of Paricalcitol Q: What are the applications of Paricalcitol Paricalcitol (COLD SHIPMENT REQUIRED) (1499403) CS-1390 Zemplar (1R,3R)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5S,E)-6-Hydroxy-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)cyclohexane-1,3-diol Paricalciferol Zemplarr 131918-61-1 131919-61-1 Vitamin D3 analogs Chiral Reagents Intermediates & Fine Chemicals Pharmaceuticals 131918-61-1