Calcium dobesilate
- CAS No.
- 20123-80-2
- Chemical Name:
- Calcium dobesilate
- Synonyms
- 205-E;doxium;dexium;Calciumdobesilat;CALCIUM DOBESILATE;5-benzenesulfonate;calcium dihydroxy-2;Qiangbenhuangsuangai;Dobesilate calcium salt;CALCIUMDOBESILATECAPSULE
- CBNumber:
- CB5713183
- Molecular Formula:
- 2C6H5O5S.Ca
- Molecular Weight:
- 418.41
- MOL File:
- 20123-80-2.mol
- Modify Date:
- 2024/7/3 16:00:59
| Melting point | >300° (dec) |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | H2O: soluble15mg/mL, clear |
| form | powder |
| color | white to beige |
| Stability | Hygroscopic |
| InChIKey | QGNBTYAQAPLTMX-UHFFFAOYSA-L |
| CAS DataBase Reference | 20123-80-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| Toxicity | LD50 in mice: 700 mg/kg (Esteve-Subirana) |
Calcium dobesilate price More Price(2)
Calcium dobesilate Chemical Properties,Uses,Production
Description
Calcium dobesilate is a vasoprotective. It is the calcium salt of dobesilic acid. It is a synthetic molecule with the ability to reduce capillary permeability in the body. In Switzerland the drug is sold by the pharmaceutical company OM Pharma under the trade name of Doxium in capsules containing 500 mg of active ingredient.
Calcium dobesilate is indicated in states of fragility and altered capillary permeability, e.g. diabetic retinopathy, chronic venous disease and hemorrhoidal disease. In combination with lidocaine or with lidocaine and dexamethasone, the drug enters the composition of preparations for the therapy of hemorrhoidal disease. In association with potassium hydrodex-sulfate[citation needed] enters the composition of adjuvant gels in the treatment of varicose veins. The efficacy of calcium dobesilate has been described in patients with microangiopathies such as diabetic retinopathy and diabetic nephropathy.
Chemical Properties
White or almost white, hygroscopic powder.
Uses
Calcium dobesilate is an antioxidant that has been used to treat diabetic retinopathy, in which it slows progression of the disease during long-term oral treatment by reducing microvascular permeability, leading to improved visual acuity. It not only acts as an antioxidant but also stimulates endothelial production of nitric oxide.
Indications
Calcium dobesilate (CaD) is a widely prescribed veno-tonic drug for CVI, diabetic retinopathy, and the symptoms of hemorrhoid attacks.
Calcium dobesilate is also almost the only one angioprotective drug that recently remains the object of interest in treatment of diabetic retinopathy including clinical studies (Leal et al. 2010, Einarsdottir & Stefansson, 2009, Ribeiro et al., 2006), and even it was used as a standard for determination of the particular activity of a traditional Chinese herbal medicine preparation (Luo et al. 2009).
General Description
Dobesilate calcium belongs to the family of fibroblast growth factor (FGF) inhibitors.
Side effects
Fever
Skin reactions
Arthralgia(joint pain)
Gastrointestinal disorders
Agranulocytosis (lower white blood cell count)
Calcium dobesilate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Global Calcium Pvt Ltd | +91-8050750904 +91-8040554500 | Karnataka, India | 132 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Bluemark International | 08069023792Ext 766 | Gujarat, India | 18 | 58 | Inquiry |
| Triveni Interchem Private Limited (Group Of Triveni... | 08046042087 | Gujarat, India | 497 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Accuris Healthcare and Allied Services LLP | 08046061314 | Ahmedabad, India | 15 | 58 | Inquiry |
| Hebei Yanxi Chemical Co., Ltd. | +86-17531190177; +8617531190177 | China | 6011 | 58 | Inquiry |
| Hebei Guanlang Biotechnology Co,.LTD | +86-19930503253; +8619930503252 | China | 5904 | 58 | Inquiry |
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