Ergosterol
- CAS No.
- 57-87-4
- Chemical Name:
- Ergosterol
- Synonyms
- PROVITAMIN D2;Ganoderma lucidum Polysaccharide;ERGOSTERIN;ERGOSTERINE;Provitamin D;(3β，22E)-ergosta-5，7，22-trien-3-ol;24-Methylcholesta-5,7,22-trien-3β-ol;ERGOSTEROL;provitamind;ERGOSTEROL(P)
- CBNumber:
- CB5763603
- Molecular Formula:
- C28H44O
- Molecular Weight:
- 396.66
- MOL File:
- 57-87-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/3/14 18:29:10
| Melting point | 156-158 °C(lit.) |
|---|---|
| alpha | -120 º (c=1, CHC13) |
| Boiling point | 250 °C (1.3 mmHg) |
| Density | 0.9784 (rough estimate) |
| refractive index | -112.5 ° (C=1, THF) |
| storage temp. | -20°C |
| solubility | Acetone (Slightly, Heated), Chloroform (Slightly), Ethyl Acetate (Slightly, Heated) |
| pka | 14.91±0.70(Predicted) |
| form | Crystalline Powder or Crystalline Needles |
| color | White to off-white |
| optical activity | [α]20/D 120±10°, c = 1% in chloroform |
| Water Solubility | PRACTICALLY INSOLUBLE |
| Sensitive | Light Sensitive |
| Merck | 14,3659 |
| BRN | 2338604 |
| Stability | Stable, but may be light or air sensitive. Incompatible with acids, strong oxidizing agents. |
| InChIKey | DNVPQKQSNYMLRS-APGDWVJJSA-N |
| LogP | 9.300 (est) |
| CAS DataBase Reference | 57-87-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Ergosterol(57-87-4) |
| EPA Substance Registry System | Ergosta-5,7,22-trien-3-ol, (3.beta.,22E)- (57-87-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H413 | |||||||||
| Precautionary statements | P273 | |||||||||
| Hazard Codes | T+,T,Xn | |||||||||
| Risk Statements | 28-48/20/22-40-38-25-67-36/38-22-20-63 | |||||||||
| Safety Statements | 28-36/37-45-26 | |||||||||
| RIDADR | UN 2811 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 1-3-8-10 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29334900 | |||||||||
| NFPA 704 |
|
Ergosterol price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | E6510 | Ergosterol ≥75% | 57-87-4 | 5G | ₹4535.68 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | E6510 | Ergosterol ≥75% | 57-87-4 | 10G | ₹8389.38 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1512 | Ergosterol Pharmaceutical Secondary Standard; Certified Reference Material | 57-87-4 | 200MG | ₹10013.13 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | E6510 | Ergosterol ≥75% | 57-87-4 | 25G | ₹18142.7 | 2022-06-14 | Buy |
| ALFA India | ALF-B23840-14 | Ergosterol, 96%, may cont. up to ca 6% water | 57-87-4 | 25g | ₹14647 | 2022-05-26 | Buy |
Ergosterol Chemical Properties,Uses,Production
Description
Ergosterol is a membrane component and with few exceptions is restricted to eumycotic fungi (101). As a constituent of intact membranes, its abundance should reflect the amount of living fungal biomass in an environment. This membrane component has been related to biomass by a number of investigators and the values range from 1.9 to 11.5 mg ergosterol g?1 mycelium (102). These conversion factors yield very high values for fungal biomass, and seem unrealistic (102) when compared with independent measures of bacterial biomass. It is likely that the ergosterol assay detects nonliving hyphae and these measures may overestimate viable fungal biomass. Similarly, chitin is a dominant cell wall component in most fungi and has been proposed as a unique marker for total fungal biomass.
Chemical Properties
solid
Uses
Ergosterol is a steroid alcohol that when irradiated with ultraviolet light yields calciferol (vitamin d2). irradiated ergosterol is added to milk for vitamin d fortification.
Definition
ergosterol: A sterol occurring infungi, bacteria, algae, and plants. It isconverted into vitamin D2 by the actionof ultraviolet light.
General Description
Ergosterol or provitamin D2 is a biological precursor of Vitamin D2. It is found predominantly in cell membranes of fungi and protists such as trypanosomes.
Hazard
Due to its ability to catalyze calcium deposition in the bony structure (thus preventing rickets), overdosage of vitamin D may be harmful.
Purification Methods
Crystallise ergosterol from EtOAc, then from ethylene dichloride or EtOH/*C6H6 (3:1). It has been purified by conversion to the isobutyl ester which crystallises from Et2O/Me2CO (1:3) with m: turbid at 148o, melts at 159o and becomes clear at 162o, followed by hydrolysis, [Bill & Honeywell J Biol Chem 80 15 1938]. When crystallised from EtOH, it forms the 1.5-hydrate m 168o. The water is difficult to remove giving an amorphous solid m 166-183o, b 250o/high vacuum. It is light sensitive. The benzoate has m 169-171o, after crystallisation from Me2CO/*C6H6 (4:1) after prolonged standing at 0o and becomes highly charged, with [] D20 -177o (c 1, CHCl3). [UV of sterols: Hogness et al. J Biol Chem 120 239 1937, Beilstein 6 IV 4407.]
Ergosterol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Spectrochem Private Limited | 08048372608Ext 246 | Maharashtra, India | 1056 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Dr. Jcr Bio-Sciences Private Limited. | 91-9849274624 | Hyderabad, India | 49 | 58 | Inquiry |
| Pharmaffiliates Analytics & Synthetics (P) Ltd. | 91-172-5066494 | Haryana, India | 631 | 58 | Inquiry |
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