Betulin
- CAS No.
- 473-98-3
- Chemical Name:
- Betulin
- Synonyms
- TROCHOL;Betuline;Birch bark extract;BETULINOL;betula camphor;(1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-3a-(Hydroxymethyl)-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysen-9-ol;BetuL;etulin;BETULIN;BETULOL
- CBNumber:
- CB1301612
- Molecular Formula:
- C30H50O2
- Molecular Weight:
- 442.72
- MOL File:
- 473-98-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/1/27 9:38:02
| Melting point | 256-257 °C(lit.) |
|---|---|
| alpha | D15 +20° (c = 2 in pyridine) |
| Boiling point | 493.26°C (rough estimate) |
| Density | 0.9882 (rough estimate) |
| refractive index | 1.5045 (estimate) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly, Heated) |
| form | Off-white powder |
| pka | 15.10±0.10(Predicted) |
| color | Pale Brown to Beige |
| optical activity | +2015 (c 6, pyridine) |
| Merck | 14,1189 |
| Stability | Hygroscopic |
| InChIKey | FVWJYYTZTCVBKE-ROUWMTJPSA-N |
| LogP | 8.607 (est) |
| CAS DataBase Reference | 473-98-3(CAS DataBase Reference) |
| NIST Chemistry Reference | Betulin(473-98-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H371 | |||||||||
| Precautionary statements | P260-P264-P270-P308+P311-P405-P501 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 36/37/38-20/21/22-68/20/21/22-68 | |||||||||
| Safety Statements | 36/37-36-26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | OK5755000 | |||||||||
| HS Code | 29181985 | |||||||||
| NFPA 704 |
|
Betulin price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | B9757 | Betulin ≥98% | 473-98-3 | 1G | ₹17309.18 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | B9757 | Betulin ≥98% | 473-98-3 | 5G | ₹35116.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 92648 | Betulin analytical standard | 473-98-3 | 50MG | ₹11864.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 569371 | SREBP Processing Inhibitor, Betulin - CAS 473-98-3 - Calbiochem The SREBP Processing Inhibitor, Betulin, also referenced under CAS 473-98-3, controls the biological activity of SCAP (SREBP cleavage activating prote | 473-98-3 | 250MG | ₹8310 | 2022-06-14 | Buy |
| TCI Chemicals (India) | B0803 | Betulinol min. 97.0 % | 473-98-3 | 100MG | ₹7600 | 2022-05-26 | Buy |
Betulin Chemical Properties,Uses,Production
Description
Sterol regulatory element binding protein 2 (SREBP-
Chemical Properties
crystals
Uses
Betulin may be used in the preparation of betulinic acid, which shows anti-HIV, antimalarial and anti-inflammatory activities.
Definition
ChEBI: A pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-hydroxymethyl substituents.
General Description
A cell-permeable pentacyclic triterpenoid from birch bark extract that interacts with SCAP (SREBP cleavage activating protein) and prevents SREBP (sterol regulatory element-binding protein) Golgi proteolytic activation (1 to 13.55 μM in Rat hepatocytes CRL-1601) via a similar mechanism as oxysterols by inducing the association of SCAP with Insig-1 (insulin-induced gene-1), thereby causing SCAP-SREBPs complex ER retention. Unlike oxysterols, Betulin does not activate LXR to induce concomitant HMGCR (HMG-CoA reductase) degradation and SREBP-1 up-regulation. While both Betulin and HMGCR inhibitor Lovastatin (Cat. No. 438185) inhibit cellular cholesterol synthesis (by ~70% in CRL-1601 cultures with respective compound at 13.55 and 1 μM concentration), only Betulin suppresses cellular fatty acid synthesis (by ~55% at 13.55 μM in CRL-1601). Betulin is shown to exhibit comparable in vivo efficacy as Lovastatin (both dosed at 30 mg/kg/day with chow) in ameliorate high fat/cholesterol diet-induced obesity (% fat/lean tissue ratio increase from non-fat diet mice = 167, 44, and 33 in mice consuming fat diet alone, with Lovastatin, with Betulin, respectively). However, only Betulin is demonstrated to lower fasting blood glucose and insulin levels and reduce fat cell size in white adipose tissue in high fat diet mice. Fatostatin (Cat. No. 341329) in comparison does not target SCAP via sterol-binding site, nor does it induce SCAP binding to Insig-1.
Anticancer Research
In addition, triterpenoids (betulin and its derivatives) isolated from HSSEactivated the signaling pathway regulated by p53 family genes, leading to the inhibition of BC cell viability or even the induction of apoptosis. And also, theseresearchers found that all the triterpenoids had no effect on normal breast cells.These findings provide an important basis for the use of those triterpenoids in thedevelopment of alternative therapies for breast cancer treatment (Hsu et al. 2015).
Betulin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GK Chemicals | +91-7207279444 +91-7207279444 | Hyderabad, India | 340 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6700 | 30 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5870 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6768 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6739 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6754 | 58 | Inquiry |
| Natucare India | 08048372644Ext 102 | Mumbai, India | 8 | 58 | Inquiry |
| Biopharmacule Speciality Chemicals P Ltd (India) | +91 40 6462 1866 | Hyderabad, India | 526 | 58 | Inquiry |
| Hovane Phytochemicals Co., Ltd | +86-17340288373 | China | 33 | 58 | Inquiry |
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