Betulinic acid
- CAS No.
- 472-15-1
- Chemical Name:
- Betulinic acid
- Synonyms
- MAIRIN;BETULIC ACID;Betulinic;ALS-357;Betulinic acid technical grade, 90%;(1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-hydroxy-5a,5b,8,8,11a-pentaMethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysene-3a-carboxylic acid;Platanol;Ccris 6748;Nsc 113090;Nsc 677578
- CBNumber:
- CB4667160
- Molecular Formula:
- C30H48O3
- Molecular Weight:
- 456.71
- MOL File:
- 472-15-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:09
| Melting point | 295-298 °C (dec.) (lit.) |
|---|---|
| Boiling point | 550.0±33.0 °C(Predicted) |
| alpha | D25 +7.5° (c = 0.37 in pyridine) |
| Density | 1.065±0.06 g/cm3(Predicted) |
| refractive index | 7.8 ° (C=0.9, Pyridine) |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml). |
| form | Solid |
| pka | 4.61±0.70(Predicted) |
| color | White or off-white |
| optical activity | [α]20/D +7.8°, c = 0.9 in pyridine |
| Merck | 14,1190 |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months. |
| InChIKey | QGJZLNKBHJESQX-FZFNOLFKSA-N |
| LogP | 7.653 (est) |
| CAS DataBase Reference | 472-15-1(CAS DataBase Reference) |
Betulinic acid price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | B8936 | Betulinic acid ≥98% (HPLC) | 472-15-1 | 5MG | ₹4968.68 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | B8936 | Betulinic acid ≥98% (HPLC) | 472-15-1 | 25MG | ₹16508.13 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 91466 | Betulinic acid analytical standard | 472-15-1 | 10MG | ₹9601.78 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 855057 | Betulinic acid technical grade, 90% | 472-15-1 | 100MG | ₹11474.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 855057 | Betulinic acid technical grade, 90% | 472-15-1 | 500MG | ₹29909.48 | 2022-06-14 | Buy |
Betulinic acid Chemical Properties,Uses,Production
Chemical Properties
colorless Needles
Uses
Betulinic Acid is a natural pentacyclic triterpenoid. Betulinic Acid displays anti-inflammatory and anti-HIV activity. Betulinic Acid selectively induces apoptosis in tumor cells by directly activati ng the mitochondrial pathway of apoptosis through a p53- and CD95-independent mechanism. Betulinic Acid also exhibits TGR5 agonist activity
Definition
ChEBI: A pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-carboxy substituents. It is found in the bark and other plant parts of several species of plants including Syzygium cla iflorum. It exhibits anti-HIV, antimalarial, antineoplastic and anti-inflammatory properties.
General Description
Betulinic acid is a lupane-type triterpene, which can be prepared from betulin via oxidation using chromium oxide (VI). Along with anti-HIV-1 and anti-tumor activity, it also shows other bioactivities such as anti-inflammatory, antibacterial, in vitro antimalarial, anthelmintic and antioxidant activities.
Biological Activity
Natural triterpenoid that displays anti-HIV and antitumor activity. Induces the production of reactive oxygen species (ROS) and activates NF- κ B. Exhibits TRG5 agonist activity (EC 50 = 1.04 μ M).
Anticancer Research
This compound is a pentacyclic triterpene obtained from Betula and Zizyphus species,which shows selective cytotoxicity against human melanoma cells (Shoeb2006). It generates reactive oxygen species, activates MAPK cascade, inhibitstopoisomerase I, inhibits angiogenesis, modulates pro-growth transcriptionalactivators, modulates the activity of aminopeptidase-N, and thereby inducesapoptosis in cancer cells (Desai et al. 2008; Fulda 2008).
Betulinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Dr. ASCRO Bio Sciences Private Limited | +undefined-7382260502 +undefined-+91 9182680914 | Telangana, India | 51 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Praval Phyto Chem | 09440407687 | Hyderabad, India | 3 | 58 | Inquiry |
| Natucare India | 08048372644Ext 102 | Mumbai, India | 8 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Chempure | 08047626574 | Mumbai, India | 144 | 58 | Inquiry |
| Dr. ASCRO Bio Sciences Private Limited | +91 7382260502,+91 9440676190 | Telangana, India | 50 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
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