Ceftiofur hydrochloride
- CAS No.
- 103980-44-5
- Chemical Name:
- Ceftiofur hydrochloride
- Synonyms
- CEFTIOFUR HCL;U-67279A;U 64279A;Excenel RTU;Unii-6822A07436;Ceftiofur hydrochlor;Excenel hydrochloride;CEFTIOFUR HYDROCHLORIDE;-3-(((furan-2-carbonyl);Ceftiovir hydrochloride
- CBNumber:
- CB5713789
- Molecular Formula:
- C19H18ClN5O7S3
- Molecular Weight:
- 560.01
- MOL File:
- 103980-44-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/23 17:50:46
| Melting point | >190°C (dec.) |
|---|---|
| alpha | -92～-98°(D/20℃)(c=0.2,CH3OH) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| color | Off-White |
| InChIKey | KEQFDTJEEQKVLM-JUODUXDSSA-N |
| SMILES | C(C1=C(CS[C@]2([H])[C@H](NC(=O)/C(/C3N=C(N)SC=3)=N\OC)C(=O)N12)CSC(C1OC=CC=1)=O)(=O)O.Cl |&1:5,7,r| |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS07,GHS08,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H315-H319-H335-H410-H372 |
| Precautionary statements | P210-P261-P264-P271-P273-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P370+P378-P403+P233-P403+P235-P405-P501 |
| WGK Germany | 3 |
| HS Code | 2941906000 |
Ceftiofur hydrochloride Chemical Properties,Uses,Production
Description
Ceftiofur Hydrochloride is the hydrochloride salt form of ceftiofur, a semisynthetic, beta-lactamase-stable, broad-spectrum, third-generation cephalosporin with antibacterial activity. Ceftiofur binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
Chemical Properties
Off-White Solid
Uses
Ceftiofur hydrochloride (ceftiofur) has been approved for treatment against respiratory diseases in many animals.1,3,8–10 The recommended dosage regimen of ceftiofur for the treatment of swine respiratory disease is 3–5 mg/kg body weight (BW) administered intramuscularly once daily for 3–5 consecutive days.
Application
Ceftiofur hydrochloride is used for the treatment and control of infections in cattle and pigs caused by susceptible pathogens. It is approved for the treatment of bovine respiratory disease caused by Bartonella mansoni, Bartonella multocida and Bartonella somniferum (formerly Bartonella somniferum).
Ceftiofur hydrochloride is also used for the treatment of bovine interdigital necrotizing bacillosis (rotten foot disease) caused by Fusobacterium necrophorum or Bacteroides melaninogenicus. Ceftiofur hydrochloride has been shown to be effective at a dose of 2.2 mg/kg for the treatment of acute postpartum onychomycosis in dairy cows or by intrauterine instillation (1 g) for the treatment of retained foetal membranes.
Ceftiofur hydrochloride can be used for the treatment of SRD caused by Actinobacillus, Plasmodium multocida, Salmonella cholera and Streptococcus suis.Ceftiofur hydrochloride and ceftiofur amorphous acid can also be administered via the intra-udder route in dairy cows. For intramammary use, a specific formulation (Spectramast DC) is recommended. Although ceftiofur sodium has been used to treat infections in horses and dogs, there is little experience with the administration of ceftiofur sodium hydrochloride in these species.
Ceftiofur hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Bulat Pharmaceutical Pvt Ltd | +91-8448085659 +91-8448085660 | Haryana, India | 123 | 58 | Inquiry |
| Orchid Pharma Ltd. (Formerly Known as Orchid Chemicals and Pharmaceuticals Ltd.) | +91-4428244254 +91-4428244254 | Tamil Nadu, India | 28 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| Ayon PharmaChem | 91-22-28638348 | Maharashtra, India | 303 | 58 | Inquiry |
| ORCHID PHARMA LIMITED | +91–44–2744 4471/72/73/74/75/76/77/78 | New Delhi, India | 32 | 58 | Inquiry |
| Uni-Chemie International | 91-22-28881114 | Maharashtra, India | 62 | 58 | Inquiry |
| Gansai International | 91-40-27425615 | Andhra Pradesh, India | 159 | 58 | Inquiry |
| Medkem Laboratories | 91-40-23700606 | Andhra Pradesh, India | 297 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Global Chem Asia Pacific | 91-9849161572 | Hyderabad, India | 255 | 58 | Inquiry |
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