Cysteamine hydrochloride
- CAS No.
- 156-57-0
- Chemical Name:
- Cysteamine hydrochloride
- Synonyms
- CYSTEAMINE HCL;2-AMINOETHANETHIOL HYDROCHLORIDE;2-MERCAPTOETHYLAMINE HYDROCHLORIDE;Mercaptamine hydrochloride;mercaptoethylammonium chloride;2-Mercaptoethylammonium chloride;2-AMINOETHANE-1-THIOL HYDROCHLORIDE;2-AMINOETHANETHIOL HCL;Aminoethanethiol hydrochloride;DECARBOXYCYSTEINE HYDROCHLORIDE
- CBNumber:
- CB9337215
- Molecular Formula:
- C2H8ClNS
- Molecular Weight:
- 113.61
- MOL File:
- 156-57-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/7 16:07:22
| Melting point | 67-71 °C |
|---|---|
| Boiling point | 238.5℃[at 101 325 Pa] |
| Density | 0.75 |
| vapor pressure | 5.333Pa at 25℃ |
| refractive index | 1.6100 (estimate) |
| storage temp. | 2-8°C |
| solubility | H2O: 1 m at 20 °C, clear, colorless |
| form | Crystalline Powder or Pellets |
| color | White |
| PH | 3.3-5.0 (400g/l, H2O, 20℃) |
| Water Solubility | VERY SOLUBLE |
| Sensitive | Hygroscopic |
| λmax | λ: 280 nm Amax: ≤0.3 |
| Merck | 14,2779 |
| BRN | 3590083 |
| Stability | Stable, but hygroscopic. Incompatible with strong oxidizing agents. |
| InChIKey | OGMADIBCHLQMIP-UHFFFAOYSA-N |
| LogP | -2.14 at 25℃ |
| CAS DataBase Reference | 156-57-0(CAS DataBase Reference) |
| EPA Substance Registry System | Cysteamine hydrochloride (156-57-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H317-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 36/37/39-26-36 | |||||||||
| RIDADR | UN 3335 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | KJ0200000 | |||||||||
| F | 1-3-10-13 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29309070 | |||||||||
| Toxicity | LD50 orally in Rabbit: 642 mg/kg | |||||||||
| NFPA 704 |
|
Cysteamine hydrochloride price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | V900342 | Cysteamine hydrochloride Vetec?, reagent grade, 98% | 156-57-0 | 5G | ₹1515.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | M6500 | Cysteamine hydrochloride ≥98% (titration) | 156-57-0 | 25G | ₹4100 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.02835 | Cysteaminium chloride for synthesis | 156-57-0 | 10G | ₹2750 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | M6500 | Cysteamine hydrochloride ≥98% (titration) | 156-57-0 | 100G | ₹14765.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.02835 | Cysteaminium chloride for synthesis | 156-57-0 | 25G | ₹6110 | 2022-06-14 | Buy |
Cysteamine hydrochloride Chemical Properties,Uses,Production
Description
Cysteamine is a stable aminothiol with radioprotective activities. It reduces ionizing radiation-induced death and chromosomal damage in mice in a dose-dependent manner. Cysteamine binds rapidly and temporarily to plasma proteins upon administration and this activity is directly correlated to its radioprotective effects. In vitro, 0.1 mM cysteamine depletes 90% of free cystine from cystinotic fibroblasts. Formulations containing cysteamine have been used to treat nephropathic cystinosis and reduce glomerular deterioration in humans.
Chemical Properties
White Solid
Uses
Cysteamine hydrochloride is used as an antioxidant and in radiation therapy.
General Description
Cysteamine is an aminothiol that can reduce important oxidized disulfide molecules such as cystine to yield cysteine.
Hazard
Toxic by inhalation and ingestion.
Synthesis
In particular to synthesizing cysteamine hydrochloride in alkali surroundings, which is characterized in that ethanolamine solution and sulfate solution are used as raw material; 2- amino ethyl sulfate is firstly synthesized before made into ring in alkaline solution by 2-amino ethyl sulfate and carbon disulfide, thereby getting Alpha -mercaptothiazoline; alkaline hydrolysis is made upon Alpha -mercaptothiazoline to produce cysteamine hydrochloride.
Purification Methods
Purify the salt by recrystallisation from EtOH. It is freely soluble in H2O and should be stored in a dry atmosphere. [Mills & Bogert J Am Chem Soc 62 1177 1940.] The picrate has m 125-126o; see previous entry for free base. [Beilstein 4 IV 1570.]
Cysteamine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
1of3
chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| Gland Pharma Ltd | +91-7075736524 +91-9700602423 | Telangana, India | 44 | 58 | Inquiry |
| Apicore Pharmaceuticals Pvt Ltd | +91-2662267177 +91-2662267166 | Gujarat, India | 181 | 58 | Inquiry |
| Molychem | 08048372666Ext 559 | Mumbai, India | 577 | 58 | Inquiry |
| Akshaya Laboratories Pvt. Ltd | -64642624 | Hyderabad, India | 125 | 58 | Inquiry |
| Manav Bio -Chem Impex Pvt Ltd | 91-22-25916910 | Maharashtra, India | 204 | 58 | Inquiry |
| Oxford laboratories | +91 250 239 0032 | Maharashtra, India | 652 | 58 | Inquiry |
| Jay Chem Marketing | 08048964412 | Mumbai, India | 231 | 58 | Inquiry |
| ChemOrbit International | 91-40-23712139 | Hyderabad, India | 264 | 58 | Inquiry |
| Chemrich Fine Chemicals Pvt., Ltd. | 91-40-23607444 | Hyderabad, India | 400 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| JSK Chemicals | 58 |
| Gland Pharma Ltd | 58 |
| Apicore Pharmaceuticals Pvt Ltd | 58 |
| Molychem | 58 |
| Akshaya Laboratories Pvt. Ltd | 58 |
| Manav Bio -Chem Impex Pvt Ltd | 58 |
| Oxford laboratories | 58 |
| Jay Chem Marketing | 58 |
| ChemOrbit International | 58 |
| Chemrich Fine Chemicals Pvt., Ltd. | 58 |