Monoethanolamine
- CAS No.
- 141-43-5
- Chemical Name:
- Monoethanolamine
- Synonyms
- MONOETHANOLAMINE;2-Aminoethan-1-ol;2-AMINOETHANOL;Olamine;Aminoethanol;GLYCINOL;2-Ethanolamine;2-HYDROXYETHYLAMINE;Ethanolamine, 99%, H2O 0.5% max;MEA 90
- CBNumber:
- CB1218589
- Molecular Formula:
- C2H7NO
- Molecular Weight:
- 61.08
- MOL File:
- 141-43-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/25 20:04:51
| Melting point | 10-11 °C(lit.) |
|---|---|
| Boiling point | 170 °C(lit.) |
| Density | 1.012 g/mL at 25 °C(lit.) |
| vapor density | 2.1 (vs air) |
| vapor pressure | 0.2 mm Hg ( 20 °C) |
| refractive index |
n |
| Flash point | 200 °F |
| storage temp. | Store at +15°C to +25°C. |
| solubility | Soluble in benzene, ether, carbon tetrachloride. |
| pka | 9.5(at 25℃) |
| form | Liquid |
| color | APHA: ≤15 |
| Specific Gravity | 1.012 |
| Relative polarity | 0.651 |
| PH | 12.1 (100g/l, H2O, 20℃) |
| Odor | ammoniacal odor |
| explosive limit | 3.4-27%(V) |
| Water Solubility | miscible |
| Sensitive | Air Sensitive & Hygroscopic |
| Merck | 14,3727 |
| BRN | 505944 |
| Henry's Law Constant | 1.61(x 10-10 atm?m3/mol) at 20 °C (Bone et al., 1983) |
| Dielectric constant | 31.940000000000001 |
| Exposure limits | TLV-TWA 3 ppm (～7.5 mg/m3) (ACGIH, MSHA, and OSHA); TLV-STEL 6 ppm (～15 mg/m3) (ACGIH); IDLH 1000 ppm (NIOSH). |
| Stability | Stable. Flammable; incompatible with strong oxidizing agents, strong acids. Hygroscopic. |
| InChIKey | HZAXFHJVJLSVMW-UHFFFAOYSA-N |
| LogP | -2.3--1.91 at 25℃ |
| CAS DataBase Reference | 141-43-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Ethanolamine(141-43-5) |
| EPA Substance Registry System | Ethanolamine (141-43-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302+H312+H332-H314-H335-H412 | |||||||||
| Precautionary statements | P273-P280-P301+P312+P330-P303+P361+P353-P304+P340+P312-P305+P351+P338+P310 | |||||||||
| Hazard Codes | T,C | |||||||||
| Risk Statements | 20/21/22-34-39/23/24/25-23/24/25-10-52/53 | |||||||||
| Safety Statements | 26-36/37/39-45-61 | |||||||||
| RIDADR | UN 2924 3/PG 3 | |||||||||
| OEB | B | |||||||||
| OEL | TWA: 3 ppm (8 mg/m3), STEL: 6 ppm (15 mg/m3) | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | KJ5775000 | |||||||||
| F | 8-10-23 | |||||||||
| Autoignition Temperature | 410 °C | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29221100 | |||||||||
| Toxicity | LD50 orally in rats: 10.20 g/kg (Smyth) | |||||||||
| IDLA | 30 ppm | |||||||||
| NFPA 704 |
|
Monoethanolamine price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | E9508 | Ethanolamine ≥98% | 141-43-5 | 100ML | ₹3929.48 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | E9508 | Ethanolamine ≥98% | 141-43-5 | 500ML | ₹4481.55 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | E9508 | Ethanolamine ≥98% | 141-43-5 | 1L | ₹6235.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1490 | Monoethanolamine Pharmaceutical Secondary Standard; Certified Reference Material | 141-43-5 | 1ML | ₹15826.15 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | E9508 | Ethanolamine ≥98% | 141-43-5 | 2.5L | ₹7133.68 | 2022-06-14 | Buy |
Monoethanolamine Chemical Properties,Uses,Production
Description
Monoethanolamine is contained in many products, such as metalwork fluids. It is mainly an irritant. Traces may exist in other ethanolamine fluids.
Chemical Properties
Monoethanolamine is a clear, colorless or pale yellow-colored, moderately viscous liquid with a mild, ammoniacal odor. Ethanolamines can be detected by odor as low as 2-3 ppm.
Physical properties
Colorless, viscous, hygroscopic liquid with an unpleasant, mild, ammonia-like odor. Odor threshold concentration is 2.6 ppm (quoted, Amoore and Hautala, 1983). The lowest taste threshold concentration in potable water at 40 °C was 2.4 mg/L (Alexander et al., 1982).
Uses
Monoethanolamine is used as a dispersing agent for agricultural chemicals, in thesynthesis of surface-active agents, as a softening agent for hides, and in emulsifiers,polishes, and hair solutions.
Production Methods
Monoethanolamine is prepared commercially by the ammonolysis of ethylene oxide. The reaction yields a mixture of monoethanolamine, diethanolamine, and triethanolamine, which is separated to obtain the pure products. Monoethanolamine is also produced from the reaction between nitromethane and formaldehyde.
Definition
ChEBI: A member of the class of ethanolamines that is ethane with an amino substituent at C-1 and a hydroxy substituent at C-2, making it both a primary amine and a primary alcohol.
General Description
A clear colorless liquid with an odor resembling that of ammonia. Flash point 185°F. May attack copper, brass, and rubber. Corrosive to tissue. Moderately toxic. Produces toxic oxides of nitrogen during combustion.
Air & Water Reactions
Water soluble with evolution of heat.
Reactivity Profile
Ethanolamine is a base. Reacts with organic acids (acetic acid, acrylic acid), inorganic acids (hydrochloric acid, hydrofluoric acid, nitric acid, sulfuric acid, chlorosulfonic acid), acetic anhydride, acrolein, acrylonitrile, cellulose, epichlorohydrin, mesityl oxide, beta-propiolactone, vinyl acetate. Emits toxic fumes of nitrogen oxides when heated to decomposition [Sax, 9th ed., 1996, p. 1498].
Health Hazard
Monoethanolamine causes severe irritationof the eyes and mild to moderate irritationof the skin. The pure liquid caused rednessand swelling when applied to rabbits’ skin.The acute oral toxicity of this compound waslow in animals. The toxic symptoms includedsomnolence, lethargy, muscle contraction,and respiratory distress. The oral LD50 valuesshowed a wide variation with species.
LD50 value, oral (rabbits): 1000 mg/kg
Monoethanolamine showed reproductive tox icity when administered at a dose of850 mg/kg/day, causing 16% mortality topregnant animals (Environmental HealthResearch and Testing 1987). This study alsoindicated that monoethanolamine reduced thenumber of viable litters but had no effect onlitter size, the birth weight, or percentage sur vival of the pups.
Fire Hazard
Special Hazards of Combustion Products: Irritating vapors generated when heated.
Pharmaceutical Applications
Monoethanolamine is used primarily in pharmaceutical formulations
for buffering purposes and in the preparation of emulsions.
Other uses include as a solvent for fats and oils and as a stabilizing
agent in an injectable dextrose solution of phenytoin sodium.
Monoethanolamine is also used to produce a variety of salts with
therapeutic uses. For example, a salt of monoethanolamine with
vitamin C is used for intramuscular injection, while the salicylate
and undecenoate monoethanolamine salts are utilized respectively
in the treatment of rheumatism and as an antifungal agent.
However, the most common therapeutic use of monoethanolamine
is in the production of ethanolamine oleate injection, which is used
as a sclerosing agent.
Contact allergens
Monoethanolamine is contained in many products, such as metalworking fluids. It is mainly an irritant. Traces may exist in other ethanolamine fluids.
Safety Profile
Poison by intraperitoneal route. Moderately toxic by ingestion, skin contact, subcutaneous, intravenous, and intramuscular routes. A corrosive irritant to skin, eyes, and mucous membranes. Human mutation data reported. Flammable when exposed to heat or flame. A powerful base. Reacts violently with acetic acid, acetic anhydride, acrolein, acrylic acid, acrylonitrile, cellulose, chlorosulfonic acid, epichlorohydrin, HCl, HF, mesityl oxide, HNO3, oleum, H2SO4, p-propiolactone, vinyl acetate. To fight fire, use foam, alcohol foam, dry chemical. When heated to decomposition it emits toxic fumes of NOx. See also AMINES
Safety
Monoethanolamine is an irritant, caustic material, but when it is
used in neutralized parenteral and topical pharmaceutical formulations
it is not usually associated with adverse effects, although
hypersensitivity reactions have been reported. Monoethanolamine
salts are generally regarded as being less toxic than monoethanolamine.
LD50 (mouse, IP): 0.05 g/kg
LD50 (mouse, oral): 0.7 g/kg
LD50 (rabbit, skin): 1.0 g/kg
LD50 (rat, IM): 1.75 g/kg
LD50 (rat, IP): 0.07 g/kg
LD50 (rat, IV): 0.23 g/kg
LD50 (rat, oral): 1.72 g/kg
LD50 (rat, SC): 1.5 g/kg
Potential Exposure
Monoethanolamine is widely used in industry for scrubbing acid gases and in production of detergents and alkanolamide surfactants; to remove carbon dioxide and hydrogen from natural gas, to remove hydrogen sulfide and carbonyl sulfide; as an alkaline conditioning agent; as an intermediate for soaps, detergents, dyes, and textile agents. Diethanolamine is an absorbent for gases; a solubilizer for 2,4- dichlorophenoxyacetic acid (2,4-D); and a softener and emulsifier intermediate for detergents. It also finds use in the dye and textile industry. Triethanolamine is used as plasticizers, neutralizer for alkaline dispersions; lubricant additive; corrosion inhibitor; and in the manufacture of soaps, detergents, shampoos, shaving preparations; face and hand creams; cements, cutting oils, insecticides, surface active agents; waxes, polishes, and herbicides.
Environmental Fate
Biological. Bridié et al. (1979) reported BOD and COD values of 0.93 and 1.28 g/g using
filtered effluent from a biological sanitary waste treatment plant. These values were determined
using a standard dilution method at 20 °C for a period of 5 d. Similarly, Heukelekian and Rand
(1955) reported a 5-d BOD value of 0.85 g/g which is 65.0% of the ThOD value of 1.31 g/g.
Chemical/Physical. Aqueous chlorination of ethanolamine at high pH produced Nchloroethanolamine,
which slowly degraded to unidentified products (Antelo et al., 1981).
At an influent concentration of 1,012 mg/L, treatment with GAC resulted in an effluent
concentration of 939 mg/L. The adsorbability of the carbon used was 15 mg/g carbon (Guisti et
al., 1974).
Metabolism
Animal
Monoethanolamine is a naturally occurring constituent in mammalian urine; the excretion rate is about 1.36 mg/kg/d for rats, 0.91 mg/kg/d for rabbits, and 0.454 mg/kg/d for cats (Luck and Wilcox 1953). It was suggested that deamination of Monoethanolamine occurs in vivo, since within 24 h after administration of [15N]-Monoethanolamine to rabbits, 40% of the [15N]-label was excreted as urea (Beard and Noe 1981). Sprinson and Weliky (1969) found that labeled Monoethanolamine was extensively converted to labeled acetate in rats.Eight h after intraperitoneal injection of 0.52μmoles of [14C]-Monoethanolamine in Wistar rats, 11.5% of the injected dose was recovered as 14C02 (Taylor and Richardson 1967). At that time, about 50% of the injected radioactivity was found in the liver, and significant amounts (>2% [14C]/g tissue) were detected in the spleen and brain. In the liver, greater than 90% of the radioactivity was found in the lipid fraction; in the kidney, spleen and brain, the per cent in the lipid fraction was about 60, 30, and 54%, respectively. It was suggested that the main metabolic pathway for Monoethanolamine in rats involves its incorporation into phospholipids, presumably via exchange with serine in phosphatidylserine, resulting in the formation of phosphatidylMonoethanolamine. The incorporation of [14C]-Monoethanolamine into Monoethanolamine phosphoglycerides in liver, heart and brain has been extensively studied and is thought to occur via the CDP-Monoethanolamine pathway or by a base exchange reaction (Ansell and Spanner 1967; Weinhold and Sanders 1971; Zelinski and Choy 1982).Fifty h after topical application of [14C]-Monoethanolamine to excised pig skin in vitro (4μg/cm2), greater than 60% of the applied dose was found associated with the skin (Klain et al 1985). Twenty-four h after dermal application of [14C]- Monoethanolamine to athymic nude mice (4μg to 1.45 cm2), 19% of the applied dose was recovered in expired C02; this value was similar to that obtained after ip injection of Monoethanolamine. Radioactivity from [14C]Monoethanolamine was widely distributed in the body, with the highest levels found in the liver (26%) and kidneys (2.2%). Radioactivity was observed in hepatic phospholipids as the Monoethanolamine, serine, and choline bases, and in proteins and amino acids isolated from liver and skin sections. Urinary excretion included radioactive Monoethanolamine, urea, glycine, serine, uric acid, and choline. Thus, Monoethanolamine penetrates mouse skin and may be oxidized to C02, incorporated into hepatic phospholipids, or metabolized to amino acids.Twenty-four h after administration of [14C]-Monoethanolamine to dogs, total radioactivity in the blood was 1.69% of the administered dse (Rhodes and Case 1977). Eleven % of the dose was excreted in the urine. The half-life of the persistent low level of radioactivity in the blood was 19 d.
Human
Monoethanolamine is a naturally occurring constituent in human urine, with a mean excretion rate in males of 0.162 mg/kg/d and in females of 0.491 mg/kg/d (Luck and Wilcox 1953). [14C]-Monoethanolamine was topically applied to human skin grafted onto athymic nude mice at a dose of 4μg to a 1.45 cm2 graft area (Klain et al 1985). The rate and amount of radioactivity expired as 14C02 was similar to that described above for mice. Thus, the penetration rates of Monoethanolamine in human skin grafts and mouse skin appear to be similar.
storage
Monoethanolamine is very hygroscopic and is unstable when
exposed to light. Aqueous monoethanolamine solutions may be
sterilized by autoclaving.
When monoethanolamine is stored in large quantities, stainless
steel is preferable for long-term storage. Copper, copper alloys, zinc,
and galvanized iron are corroded by amines and should not be used
for construction of storage containers. Ethanolamines readily
absorb moisture and carbon dioxide from the air; they also react
with carbon dioxide. This can be prevented by sealing the
monoethanolamine under an inert gas. Smaller quantities of
monoethanolamine should be stored in an airtight container,
protected from light, in a cool, dry place.
Shipping
UN2491 Ethanol amine or Ethanolamine solutions, Hazard class: 8; Labels: 8-Corrosive material.
Incompatibilities
Monoethanolamine contains both a hydroxy group and a primary
amine group and will thus undergo reactions characteristic of both
alcohols and amines. Ethanolamines will react with acids to form
salts and esters. Discoloration and precipitation will take place in the presence of salts of heavy metals. Monoethanolamine reacts
with acids, acid anhydrides, acid chlorides, and esters to form amide
derivatives, and with propylene carbonate or other cyclic carbonates
to give the corresponding carbonates.
As a primary amine, monoethanolamine will react with
aldehydes and ketones to yield aldimines and ketimines. Additionally,
monoethanolamine will react with aluminum, copper, and
copper alloys to form complex salts. A violent reaction will occur
with acrolein, acrylonitrile, epichlorohydrin, propiolactone, and
vinyl acetate.
Waste Disposal
Controlled incineration; incinerator equipped with a scrubber or thermal unit to reduce nitrogen oxides emissions
Regulatory Status
Included in parenteral and nonparenteral medicines licensed in the UK and USA. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.
Monoethanolamine Preparation Products And Raw materials
Raw materials
1of2
chevron_rightPreparation Products
1of8
chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| ANJI BIOSCIENCES | +91-9000100077 +91-9000100077 | Hyderabad, India | 430 | 58 | Inquiry |
| SRI HAIMAVATHI ORGANICS | +91-040-40030163 +91-9493978643 | Hyderabad, India | 21 | 58 | Inquiry |
| UNILOSA INTERNATINAL PRIVATE LIMITED | +91-9999069917 +91-9999069917 | New Delhi, India | 152 | 58 | Inquiry |
| PAARICHEM RESOURCES LLP | +91-8104961021 +91-8104961021 | Maharashtra, India | 82 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| BASF India Limited | +91-2262785600 +91-2262785600 | Maharashtra, India | 209 | 58 | Inquiry |
| Diamines and Chemicals Limited | +91-2653534250 +91-2653534250 | Gujarat, India | 5 | 58 | Inquiry |
| Kawaken Sterling Surfactants Pvt Ltd (Sterling Group) | +91-2240320200 +91-9082327304 | Karnataka, India | 25 | 58 | Inquiry |
| MVL Medisynth Private Limited ( BALAJI AMINES LIMITED) | +91-8605000740 +91-9922472335 | Maharashtra, India | 9 | 58 | Inquiry |
| S D Fine Chem Limited | +91-9323715856 +91-9323715856 | Maharashtra, India | 368 | 58 | Inquiry |
Related articles
- Monoethanolamine: Physicochemical properties, Biological activity and Applications
- Monoethanolamine (MEA) is a clear colourless liquid with a slight ammonia odour.
- Apr 25，2024
- The Uses of Monoethanolamine
- The passage introduces the uses of Monoethanolamine.
- Nov 18，2022
141-43-5(Monoethanolamine)Related Search:
1of4
chevron_right