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Amlodipine

Amlodipine Structure
CAS No.
88150-42-9
Chemical Name:
Amlodipine
Synonyms
AMLODIPINE BASE;besylate;Amlodipin;AmL;phytoxanthin;AMlodipine-d4 Maleate;Amlodipine base (crystalline);3-ethyl 5-Methyl 2-((2-aMinoethoxy)Methyl)-4-(2-chlorophenyl)-6-Methyl-1,4-dihydropyridine-3,5-dicarboxylate;Isti;Pelmec
CBNumber:
CB9366505
Molecular Formula:
C20H25ClN2O5
Molecular Weight:
408.88
MOL File:
88150-42-9.mol
Modify Date:
2024/4/1 18:08:31
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Amlodipine Properties

Melting point 178-179°C
Boiling point 527.2±50.0 °C(Predicted)
Density 1.227±0.06 g/cm3(Predicted)
RTECS US7968329
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility Soluble in DMSO (up to 25 mg/ml), in DMF (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
pka pKa 8.6 (Uncertain)
form Almost white crystal powder
color White
Water Solubility 75.3 mg/L
BCS Class 1
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO, DMF, or ethanol may be stored at -20°C for up to 3 months.
CAS DataBase Reference 88150-42-9(CAS DataBase Reference)
EPA Substance Registry System 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester (88150-42-9)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS05,GHS06,GHS08,GHS09
Signal word  Warning
Hazard statements  H301-H318-H373-H400-H410
Precautionary statements  P260-P280i-P301+P310a-P305+P351+P338-P405-P501a
HazardClass  IRRITANT
HazardClass  6.1
Toxicity TDLo orl-chd: 400 mg/kg:BPR AJEMEN 18,581,2000
NFPA 704
0
3 0

Amlodipine Chemical Properties,Uses,Production

Description

Amlodipine is a dihydropyridine L-type calcium channel blocker that selectively inhibits calcium influx in cardiac and vascular smooth muscle. Acting as a vasodilator, amlodipine reduces blood pressure by relaxing the smooth muscle in the arterial wall, decreasing total peripheral resistance. It inhibits calcium-induced contractions in depolarized rat aorta with an IC50 value of 1.9 nM, displaying a slow rate of association and dissociation in isolated vascular and cardiac tissues. Amlodipine also demonstrates actions independent of L-type calcium channel blockade by regulating membrane fluidity and cholesterol deposition, stimulating nitric oxide production, acting as an antioxidant, and regulating matrix deposition in vitro and in vivo. Formulations containing amlodipine have been used in the treatment of hypertension.

Chemical Properties

Yellow Solid

Uses

A deuterated dihydropyridine calcium channel blocker.;Application of Labeled APIs: Labeled Amlodipine, intended for use as an internal standard for the quantification of Amlodipine by GC- or LC-mass spectrometry.

Definition

ChEBI: A fully substituted dialkyl 1,4-dihydropyridine-3,5-dicarboxylate derivative, which is used for the treatment of hypertension, chronic stable angina and confirmed or suspected vasospastic angina.

General Description

Amlodipine, 2-[, for the treatment of hypertension. Amlodipineis also marketed as a combination therapy with atorvastatinunder the tradename Norvasc for the management of highcholesterol and high blood pressure.

Hazard

Human systemic effects.

Safety Profile

Human systemic effects. Whenheated to decomposition it emits toxic vapors of NOx andCl-.

Amlodipine Preparation Products And Raw materials

Raw materials

Ethyl acetoacetate Chloroacetyl Monoethanolamine Methyl 3-aminocrotonate Maleic acid
PHENRAMINE MALEATE 2-Chlorobenzaldehyde
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Preparation Products

Levamlodipine Besylate Amlodipine nicotinate

Amlodipine Suppliers

Global( 555)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
ANWITA APIS +919000311012 Hyderabad, India 198 58 Inquiry
Anant Pharmaceuticals Pvt Ltd +91-8550986868 +91-9485998001 Haryana, India 461 58 Inquiry
Bhausa Life Sciences +91-8154986830 +91-8154986830 Gujarat, India 201 58 Inquiry
J S LABS +91-7330612784 +91-7330612784 Tamil Nadu, India 160 58 Inquiry
PRODIGIOUS LIFE SCIENCES +91-9177472555 +91-9177472555 Hyderabad, India 236 58 Inquiry
THE MOLECULEZ +91-7506703683 +91-7506703683 Maharashtra, India 79 58 Inquiry
Merix Laboratories Pvt Ltd +91-7893336376 +91-7893336376 Telangana, India 50 58 Inquiry
Cefa-Cilinas Biotics Pvt Ltd +91-7875033155 +91-8080701561 Maharashtra, India 121 58 Inquiry
GGC Chemicals And Pharmaceuticals Pvt Ltd +919824336772 Gujarat, India 14 58 Inquiry
Dodhia Group +91-9619867345 +91-9619867345 Mumbai, India 129 58 Inquiry
Supplier Advantage
ANWITA APIS 58
Anant Pharmaceuticals Pvt Ltd 58
Bhausa Life Sciences 58
J S LABS 58
PRODIGIOUS LIFE SCIENCES 58
THE MOLECULEZ 58
Merix Laboratories Pvt Ltd 58
Cefa-Cilinas Biotics Pvt Ltd 58
GGC Chemicals And Pharmaceuticals Pvt Ltd 58
Dodhia Group 58

Amlodipine Spectrum

Amlodipine(88150-42-9)1HNMR

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AMLODIPINE MM(CRM STANDARD) Amlodipine&Int AmlodipineBesylate/Maleate 3,5-Pyridinedicarboxylic acid, 2-(2-aminoethoxy)methyl-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester ethyl methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate Pelmec Racemic Amlodipine 3,5-pyridinedicarboxylic acid, 1,4-dihydro-2-((2-aminoethoxy)methyl)-4-(2-chlor 3-ethyl 5-methyl ester Amlodipine Besilate Imp.(EP) 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic acid O3-ethyl O5-methyl ester Amlodipine besilate (JAN) Amlodipine besylate (USAN) Isti O3-ethyl O5-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate Amlodipine, >=99% (RS)-3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate 4-(2-chloro-phenyl-2(3-(1,3-dioxo-l,3-dihydro-isoindol-2yl-prpionyl)6-methyl-pyridin3, 5-dicarboxylic acid-ethyl-ethyl ester 5-methyl ester (p-2) of RS amlodipine besylate AMlodipine besylate, >95% Amlodipine Besylate IMP Amlodipine (base and/or unspecified salts) AMLODIPINE (BASE & SALTS) Amlodipine ( Amlodipine Benzenesulfonate) 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1，4-dihydro-3，5-pyridinedicarboxylic acid 5-methyl 3-ethyl ester UK-48340 UK-48340-11 2-(2-Aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-ethyl=5-methyl ester 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydro-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester AMLODIPINE methyl ethyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate LOTREL 3-ethyl5-methylester 2-Methyl-4-(2-chlorophenyl)-6-[[(2-aminoethyl)oxy]methyl]-1,4-dihydro-3,5-pyridinedicarboxylic acid 3-methyl 5-ethyl ester 4-(2-Chlorophenyl)-2-methyl-6-(2-aminoethoxymethyl)-1,4-dihydro-3,5-pyridinedicarboxylic acid 3-methyl 5-ethyl ester 4-(2-Chlorophenyl)-6-methyl-2-(2-aminoethoxymethyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-ethyl 5-methyl ester 3-ethyl 5-Methyl (4S)-2-[(2-aMinoethoxy)Methyl]-4-(2-chlorophenyl)-6-Methyl-1,4-dihydropyridine-3,5-dicarboxylate AMlodipine(Norvasc) AMlodiping Besylate (R,S)-AMlodipine AMlopres Intervask 2-((2-Aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester AMLODIPINE (RS)-3-ETHYL-5-METHYL-2[(2-AMINOETHOXY)METHYL]-4-(2-CHLOROPHENYL)-6-METHYL-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE 3,5-pyridinedicarboxylicacid,1,4-dihydro-2-((2-aminoethoxy)methyl)-4-(2-chlor (R)-3-ethyl 5-methyl 2 [2H4]-Amlodipine besylate odipine besyL Amlodipine Solution in Methanol, 100μg/mL Amlodipine USP/EP/BP Amlodipine (UK-48340 amlodipineQ: What is amlodipine Q: What is the CAS Number of amlodipine Q: What is the storage condition of amlodipine Q: What are the applications of amlodipine AMLODIPINE BASE Amlodipin besylate 3-ethyl 5-Methyl 2-((2-aMinoethoxy)Methyl)-4-(2-chlorophenyl)-6-Methyl-1,4-dihydropyridine-3,5-dicarboxylate AMlodipine-d4 Maleate Amlodipine base (crystalline) phytoxanthin AmL