ChemicalBook > Product Catalog >Chemical Reagents >Organic reagents >Esters >Methyl ester compound >Methyl 3-aminocrotonate
Methyl 3-aminocrotonate
- CAS No.
- 14205-39-1
- Chemical Name:
- Methyl 3-aminocrotonate
- Synonyms
- Methyl (Z)-3-Aminobut-2-enoate;3-Aminocrotonate;(Z)-Methyl 3-aMinobut-2-enoate;methyl (E)-3-aminobut-2-enoate;3-Amino-but-2-enoic acid methyl ester;PALO-012;Nifedipine-4;Methyl 3-aminocroton;Nifedipine Impurity 5;Methyl 3-aminocrotote
- CBNumber:
- CB2222855
- Molecular Formula:
- C5H9NO2
- Molecular Weight:
- 115.13
- MOL File:
- 14205-39-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/9/5 22:20:32
| Melting point | 81-83 °C(lit.) |
|---|---|
| Boiling point | 112°C 42mm |
| Density | 1.1808 (rough estimate) |
| vapor pressure | 2.79-2.853hPa at 25℃ |
| refractive index | 1.4538 (estimate) |
| Flash point | 91 °C |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | 18g/l |
| form | Crystalline Powder |
| pka | 5.27±0.70(Predicted) |
| color | White to slightly yellow |
| PH | 8-9 (18g/l, H2O, 20℃) |
| Water Solubility | insoluble |
| Sensitive | Hygroscopic |
| BRN | 956592 |
| InChIKey | XKORCTIIRYKLLG-ONEGZZNKSA-N |
| LogP | -0.27 at 25℃ |
| CAS DataBase Reference | 14205-39-1(CAS DataBase Reference) |
| EPA Substance Registry System | 2-Butenoic acid, 3-amino-, methyl ester (14205-39-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H317-H318 | |||||||||
| Precautionary statements | P280-P301+P312+P330-P302+P352-P305+P351+P338+P310 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 37/39-26-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | EM9092500 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29224995 | |||||||||
| NFPA 704 |
|
Methyl 3-aminocrotonate price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 688894 | Methyl 3-aminocrotonate Arxada quality, 98.0-100.3% (w/w) (GC) | 14205-39-1 | 1KG | ₹27690.35 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 688894 | Methyl 3-aminocrotonate Arxada quality, 98.0-100.3% (w/w) (GC) | 14205-39-1 | 10KG | ₹272616.8 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 688894 | Methyl 3-aminocrotonate Arxada quality, 98.0-100.3% (w/w) (GC) | 14205-39-1 | 50KG | ₹503416.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 129712 | Methyl 3-aminocrotonate 97% | 14205-39-1 | 100G | ₹2392.33 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 129712 | Methyl 3-aminocrotonate 97% | 14205-39-1 | 500G | ₹7122.85 | 2022-06-14 | Buy |
Methyl 3-aminocrotonate Chemical Properties,Uses,Production
Chemical Properties
Crystals, yellowish-white
Uses
Methyl 3-aminocrotonate is used as intermediate for the syntheses of pharmaceuticals (e.g. 1,4-dihydropyridine derivatives) as well as for the manufacture of stabilizers and plastics. Product Data Sheet
Preparation
3-Aminocrotonate Esters, e.g., methyl 3- aminocrotonate [14205-39-1] (3-amino-2-butenoic acid, methyl ester) can be prepared by treatment of acetoacetates with aqueous ammonia. They are mainly used in the production of a series of the dihydropyridine-type calcium antagonists.
Application
Methyl 3-aminocrotonate reacts with benzene to form the corresponding E-2-phenyliodonio tosylate in good yield. This new alkenyl iodonium salt upon reaction with various nucleophiles offers an easy access to substituted enamine derivatives of crotonic acid. The reaction can be also extended to N-substituted crotonates[1].
General Description
Methyl 3-aminocrotonate undergoes waste-free solid-state cascade reaction with crystalline ninhydrin.
References
[1] IOANNIS PAPOUTSIS; Anastasios V ?; Spyros Spyroudis ?. Reactivity of a new alkenyl phenyliodonium tosylate derived from methyl 3-aminocrotonate[J]. Tetrahedron, 1998. DOI:10.1016/S0040-4020(97)10354-4.
Methyl 3-aminocrotonate Preparation Products And Raw materials
Raw materials
Preparation Products
2(1H)-PYRIDINONE, 4-HYDROXY-3,6-DIMETHYL-
Methyl 6-chloro-2-Methylnicotinate
4-(2,3-Dichlorophenyl)-2,6-diMethyl-1,4-dihydropyridine-3,5-dicarboxylic acid
Felodipine 3,5-DiMethyl Ester
3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, methyl 3-(3-oxo-1,2-benzisothiazol-2(3H)-yl)propyl ester, S,S-dioxide
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Global( 584)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Glindia Chemicals | +91-9726931172 +91-9726931172 | Gujarat, India | 11 | 58 | Inquiry |
| Laxmi Organic Industries Ltd | +91-2249104444 +91-2249104444 | Maharashtra, India | 23 | 58 | Inquiry |
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| ALS INDIA LIFE SCIENCES | +91-8977036379 +91-8977036379 | Hyderabad, India | 1879 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Ralington Pharma | 58 |
| Glindia Chemicals | 58 |
| Laxmi Organic Industries Ltd | 58 |
| Bhausa Life Sciences | 58 |
| SVH BIOSCIENCES | 58 |
| GLP Pharma Standards | 58 |
| JSK Chemicals | 58 |
| PHD CHEMICALS | 58 |
| Suchem Laboratories | 58 |
| ALS INDIA LIFE SCIENCES | 58 |
14205-39-1(Methyl 3-aminocrotonate)Related Search:
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14205-39-1
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CH3CNH2CHCOOCH3
Aromatic Amino Acids
C2 to C5
Carbonyl Compounds