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Isradipine

CAS No.: 75695-93-1

Chemical Name:: Isradipine

Synonyms: Iomir;Lomir;Presca;CS-139;Prescal;Esradin;Rebfiden;Clivoten;DynaCirc;Dynacrine

CBNumber:: CB2268682

Molecular Formula:: C19H21N3O5

Molecular Weight:: 371.39

MOL File:: 75695-93-1.mol

MSDS File:: SDS

Modify Date:: 2023/6/30 15:45:59

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Isradipine Properties

Melting point	166-1680C
Boiling point	501.9±60.0 °C(Predicted)
Density	1.249±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: ~26 mg/mL
form	solid
pka	2.56±0.70(Predicted)
color	yellow
Merck	14,5240
BCS Class	2/4
Stability	Stable for 2 years from date of purchsae as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey	HMJIYCCIJYRONP-UHFFFAOYSA-N
CAS DataBase Reference	75695-93-1(CAS DataBase Reference)
NIST Chemistry Reference	Isradipine(75695-93-1)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H413
Precautionary statements	P501-P273
Safety Statements	22-24/25
WGK Germany	3
HS Code	2934990002

Isradipine price More Price(4)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	I6658	Isradipine ≥98% (HPLC), solid	75695-93-1	5MG	₹17406.6	2022-06-14	Buy
Sigma-Aldrich(India)	I6658	Isradipine ≥98% (HPLC), solid	75695-93-1	25MG	₹62785	2022-06-14	Buy
Sigma-Aldrich(India)	5.08507	Isradipine - CAS 75695-93-1 - Calbiochem A voltage gated calcium channel gating inhibitor of the dihydropyridine class.	75695-93-1	10MG	₹12940	2022-06-14	Buy
TCI Chemicals (India)	I0876	Isradipine	75695-93-1	25MG	₹11600	2022-05-26	Buy

Product number	Packaging	Price	Buy
I6658	5MG	₹17406.6	Buy
I6658	25MG	₹62785	Buy
5.08507	10MG	₹12940	Buy
I0876	25MG	₹11600	Buy

Isradipine Chemical Properties,Uses,Production

Description

Isradipine is a long-acting calcium blocker effective in the treatment of essential hypertension. The advantages of isradipine as compared with other dihydropyridine calcium antagonists include a "gentle" onset and fewer contraindications. It can be taken by patients with diabetes mellitus, chronic obstructive airway diseases, gout, congestive heart failure or ischemic heart disease.

Chemical Properties

Yellow Solid

Uses

Isradipine is a L-type calcium channel blocker, Isradipine has anti-atherosclerotic effects in animals and improves endothelium-mediated nitric oxide (NO)-dependent vasodilation in vitro. Additional studies indicate that Isradipine may provide a neuroprotective effect in a rat model of focal ischemia and that Isradipine produces a dose-dependent sparing of dopamine neuronal fibers and cell bodies.

General Description

Isradipine, 4-(4-benzofuranazyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid methyl 1-methylethyl ester (DynaCirc), is another second-generationdihydropyridine-type channel blocker. This drug, like theother second-generation analogs, is more selective for vascularsmooth muscle than for myocardial tissue. It is effectivein the treatment of stable angina, reducing the frequencyof anginal attacks and the need to use nitroglycerin.

Biological Activity

Potent and selective L-type voltage-gated Ca 2+ channel blocker. EC 50 and pA 2 values are 1.4 nM and 10.3 for relaxation of depolarization- and Ca 2+ -induced contractions of rabbit aorta respectively; EC 25 = 0.45 nM for reduction in rate of spontaneously beating guinea pig right atria. Long-acting antihypertensive agent in vivo , exerting primary effects on vascular tissue with secondary negative chronotropic action.

Isradipine Preparation Products And Raw materials

Raw materials

Isopropyl acetoacetate Benzofuroxan Methyl 3-aminocrotonate

Preparation Products

Isradipine Suppliers

Global( 271)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Hetero Drugs Limited	+91-4023704923 +91-4023704923	Telangana, India	296	58	Inquiry
Alfa Omega Pharma	+91-8050045945 +91-9972665399	Maharashtra, India	126	58	Inquiry
OCEAN TRADING CORPORATION	+91(22) 24921669	New Delhi, India	6211	58	Inquiry
SOLARA ACTIVE PHARMA SCIENCES LTD	+91 44 4344 6700	New Delhi, India	89	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6778	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
ARCHERCHEM	91-22-28786843/ 91-22-28786842 /91-22-28786842	New Delhi, India	86	54	Inquiry
Arch Pharmalabs Limited	09867010022	Mumbai, India	63	58	Inquiry

Supplier	Advantage
Hetero Drugs Limited	58
Alfa Omega Pharma	58
OCEAN TRADING CORPORATION	58
SOLARA ACTIVE PHARMA SCIENCES LTD	58
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
TCI Chemicals (India) Pvt. Ltd.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
ARCHERCHEM	54
Arch Pharmalabs Limited	58

Isradipine Spectrum

Isradipine(75695-93-1)¹HNMR

75695-93-1(Isradipine)Related Search:

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Ebselen Bendamustine Lercanidipine Oxiracetam Elacridar

Isradipine Impurity 2（Isradipine EP Impurity B） Benzofuroxan 2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID

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PN-200-110 Presca Prescal 4-(4-Benzofurazanyl)-2，6-dimethyl-1，4-dihydro-3，5-pyridinedicarboxylic acid methyl 1-methylethyl ester 4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic [chemical name] acid methyl 1-methylethyl ester Dynacrine Iomir Rebfiden 3,5-Pyridinedicarboxylic acid, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-, methyl 1-methylethyl ester 4-(Benzofurazan-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3-methyl 5-isopropyl ester PN-200-100 [R,(-)]-4-(Benzofurazan-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3-methyl 5-(1-methylethyl) ester Isradipine Isradipin Clivoten DynaCirc Esradin Isrodipine Lomir 4-(2,1,3-Benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylicacidmethyl1-methylethylester Isradipine (200 mg) 3-Methyl 5-propan-2-yl (4R)-4-(2,1,3-benzoxadiazol-4-yl)-2,6-diMethyl-1,4-dihydropyridine-3,5-dicarboxylate Isradipine(Dynacirc) Isradipine API 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3-methyl 5-(1-methylethyl) ester Isradipine, >=99% 3-Isopropyl 5-methyl 4-(benzo[c][1,2,5]oxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-di 4-(4-BENZOFURAZANYL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID METHYL 1-METHYLETHYL ESTER 4-(2,1,3-BENZOXADIAZOL-4-YL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINECARBOXYLIC ACID METHYL 1-METHYLETHYL ESTER CS-139 (4R)-4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid O3-methyl ester O5-propan-2-yl ester Dynacirc CR PN 200-110;DYNACIRC; LOMIR; PRESCAL; DYNACIRC CR; Isradipine Solution, 100ppm Isradipine> Isradipine CRS 3,5-Pyridinedicarboxylic acid, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3-methyl 5-(1-methylethyl) ester 4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid Isopropyl Methyl Ester Isopropyl Methyl 4-(2,1,3-Benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimet Isopropyl Methyl 4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Isradipine USP/EP/BP Isradipine (PN 200-110) IsradipineQ: What is Isradipine Q: What is the CAS Number of Isradipine Q: What is the storage condition of Isradipine Q: What are the applications of Isradipine 4-(4-BChemicalbookenzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic[chemicalname]acidmethyl1-methylethylester Isradipine (1354207) Isopropyl methyl(±)-4-(4-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate 75695-93-1 75696-93-1 75695-63-1 C19H15N3O5D6 ALLEGRA Ion Channels Calcium channel Intermediates & Fine Chemicals Pharmaceuticals API