Lercanidipine
- CAS No.
- 100427-26-7
- Chemical Name:
- Lercanidipine
- Synonyms
- Rec-15-2375;Masnidipine;LERCANIDIPINE;Lercanadipine;Lercanidipine 13C-d3;LercanidipineC36H41N306;Lercanidipine USP/EP/BP;LERCANIDIPINE(FORR&DONLY);methyl [2-(3,3-diphenylpropyl-methyl-amino)-1,1-dimethyl-ethyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;LercanidipineQ: What is Lercanidipine Q: What is the CAS Number of Lercanidipine Q: What is the storage condition of Lercanidipine
- CBNumber:
- CB4133658
- Molecular Formula:
- C36H41N3O6
- Molecular Weight:
- 611.73
- MOL File:
- 100427-26-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:07
| Melting point | 118-120°C |
|---|---|
| Boiling point | 712.5±60.0 °C(Predicted) |
| Density | 1.177±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| form | Powder |
| pka | 8.66±0.50(Predicted) |
| color | Light yellow to yellow |
| CAS DataBase Reference | 100427-26-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H360 |
| Precautionary statements | P201-P308+P313 |
Lercanidipine Chemical Properties,Uses,Production
Description
Lerdip was launched in the Netherlands for hypertension. It is prepared in four steps, the last of which is a Hantsch reaction of 1-[(3,3-diphenyl)-N-methylpropylamino]- 2-methyl-2-propyl-2-(3-nitrobenzylidene)acetoacetate with methyl 3-aminocrotonate. This compound was designed to be very lipophilic which imparts the drug with a gradual onset and a long duration of action as a result of prolonged exposure to receptors by partitioning into membranes. It is an antagonist of L-type calcium channels with no activity in smooth muscle cells, is tissue selective, lacks any myocardial contractility impairment, has no neuroendocrine activation, and has negligible affinity for neurotransmitter receptors such as α1- and α2-adrenergic receptors. While sold as a racemate, the calcium channel activity is found in the (S)- isomer with the (R)-isomer being 2-orders of magnitude less active. It has an increased cardiac contractility index which is much more than Nitrendipine or nifedipine. The good selectivity causes a reduction in blood pressure with no negative inotropic effects.
Uses
Antihypertensive compound; calcium channel blocker.
Lercanidipine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Piramal Pharma Solutions | +919892735994 | Maharashtra, India | 48 | 58 | Inquiry |
| Glenmark Pharmaceuticals Limited | +912240189999 | Maharashtra, India | 93 | 58 | Inquiry |
| CTX Lifesciences Pvt Ltd | +91-2612399669 +91-7434851395 | Gujarat, India | 28 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Jigs Chemical Limited | +91 80 4290 2764 | Ahmedabad, India | 235 | 58 | Inquiry |
| Libertas | 08069033735Ext 211 | Gujarat, India | 29 | 58 | Inquiry |
| Taj Mahal Vision Chemicals Private Limited | 07942557933 | Mumbai, India | 206 | 58 | Inquiry |
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6211 | 58 | Inquiry |
| Medilink Pharmachem | +91 (79) 3007-0133 | New Delhi, India | 424 | 50 | Inquiry |
100427-26-7(Lercanidipine)Related Search:
1of4
chevron_right