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Manidipine

Manidipine Structure
CAS No.
89226-50-6
Chemical Name:
Manidipine
Synonyms
Artedil;Iperten;Manidipine;Franidipine;Manidipine 6300;Manidipine（base）;Manidipine(CV-4093);Manidipine (Manyper);Manidipine Impurity1254;Manidipine (10mM in DMSO)
CBNumber:
CB4506757
Molecular Formula:
C35H38N4O6
Molecular Weight:
610.7
MOL File:
89226-50-6.mol
MSDS File:
SDS
Modify Date:
2023/6/8 9:02:53
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Manidipine Properties

Melting point 125-128°C
Boiling point 722.0±60.0 °C(Predicted)
Density 1.232±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
solubility Soluble in DMSO > 10 mM
form Powder
pka 6.12±0.10(Predicted)
LogP 4.135

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
NFPA 704
0
2 0

Manidipine Chemical Properties,Uses,Production

Description

Manidipine is a dihydropyridine L- and T-type calcium channel blocker. It blocks recombinant rabbit L-type (α1Cα2/δβ1a) and human T-type (α1H) calcium channels expressed in Xenopus oocytes and native L-type channels in dissociated guinea pig cardiac ventricular cells (IC50 = 2.6 nM). Manidipine inhibits intracellular calcium increases induced by endothelin-1 (ET-1; ) in A7r5 rat vascular smooth muscle cells (ED50 = 1 nM) and potassium-induced contraction of isolated dog femoral and portal veins (IC50s = 24 and 2.1 nM, respectively). In vivo, it lowers blood pressure in spontaneously hypertensive rats (SHRs) when administered at a dose of 10 mg/kg and inhibits left ventricular hypertrophy in rats induced by isoproterenol when administered at a dose of 3 mg/kg. Formulations containing manidipine have been used in the treatment of hypertension.

Chemical Properties

Light Yellow Crystalline Solid

Uses

Manidipine (Manyper) is a lipophilic, third-generation, highly vasoselective dihydropyridine calcium antagonist with an IC50 of 2.6 nM. It causes systemic vasodilation by inhibiting the voltage-dependent calcium inward currents in smooth muscle cells. It

Manidipine Preparation Products And Raw materials

Raw materials

Manidipine Acetyl ketene Methyl 3-aminocrotonate Manidipine hydrochloride 1-(2-Hydroxyethyl)piperazine
Diisopropyl ether Magnesium sulfate 2-(4-Benzhydrylpiperazino)ethyl acetoacetate 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-Methyl Ester 2-(4-benzhydrylpiperazin-1-yl)ethanol
Methyl 3-nitrobenzylideneacetoacetate 3-Nitrobenzaldehyde 1-BENZHYDRYLPIPERAZINE
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Preparation Products

Manidipine Suppliers

Global( 126)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
SIMAGCHEM CORP +86-13806087780 China 17367 58 Inquiry
Shaanxi Dideu Medichem Co. Ltd +86-029-89586680 +86-18192503167 China 9030 58 Inquiry
Baoji Guokang Bio-Technology Co., Ltd. 0917-3909592 13892490616 China 9326 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Shandong Zhishang New Material Co., Ltd. +8617653113209 China 3050 58 Inquiry
Hefei TNJ Chemical Industry Co.,Ltd. 0551-65418684 +8618949823763 China 25363 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
CONIER CHEM AND PHARMA LIMITED 58
career henan chemical co 58
SIMAGCHEM CORP 58
Shaanxi Dideu Medichem Co. Ltd 58
Baoji Guokang Bio-Technology Co., Ltd. 58
InvivoChem 58
Shandong Zhishang New Material Co., Ltd. 58
Hefei TNJ Chemical Industry Co.,Ltd. 58

Manidipine Spectrum

Manidipine(89226-50-6)1HNMR

89226-50-6(Manidipine)Related Search:

Dimethyl sulfide N,N-Dimethylformamide Manidipine hydrochloride Nifedipine Dichlorodiphenylsilane
Nimodipine 1,5-Diphenylcarbazide 1,3-Diphenyl-2-thiourea Amlodipine 3,4'-DIAMINODIPHENYLMETHANE
Dimethyl fumarate Dimethyl ether Chlorodiphenylphosphine Dimethyl sulfoxide Dimethyl phthalate
Diphenyldimethoxysilane ETHANE Methyl
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2-(4-Diphenylmethyl-1-piperazinyl)ethyl methyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-(4-(diphenylmethyl)-1-piperazinyl)ethyl methyl ester 89226-75-5 (Di-hydrochloride) 1-diphenylmethyl-4-(2-hydroxyethyl)piperazine 3-{2-[4-(diphenylMethyl)piperazin-1-yl]ethyl} 5-Methyl 2,6-diMethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Manidipine (Manyper) 3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-Methyl 2,6-diMethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl Methyl Ester MANIDIPINE: MANIDIPINE DIHYDROCHLORIDE 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester (9CI) Franidipine Manidipine 6300 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] ester 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 5-methyl 3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] ester 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-[2-[4-(diphenylmethyl)piperazin-1-yl]ethyl]5-methyl ester 3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridi 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] 5-methyl ester 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl]5-methyl ester Manidipine 2-(4-(Diphenylmethyl)-1-piperazinyl)ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Manidipine(CV-4093) MANIDIPINE;CV-4093;FRANIDIPINE;(±)-MANIDIPINE Manidipine（base） Artedil Iperten 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] 5-methyl ester Manidipine (10mM in DMSO) Manidipine Impurity1254 Calcium Channel,Manidipine,Inhibitor,inhibit,Ca channels,Ca2+ channels 89226-50-6 120096-68-4 Inhibitors Artedil, Iperten Dihydropyridine Dihydropyridine Class Chemicals Intermediates & Fine Chemicals Pharmaceuticals