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Nimodipine

Nimodipine Structure
CAS No.
66085-59-4
Chemical Name:
Nimodipine
Synonyms
NIMOTOP;2-methyo-xyethyl 1-methylethyl ester;1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-isopropyl 5-(2-methoxyethyl) ester;Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate, 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl 1-methylethyl ester;ADMON;PERIPLUM;Nimodipin;Nimodipime;NIMODIPINE;BAY E 9736
CBNumber:
CB1398087
Molecular Formula:
C21H26N2O7
Molecular Weight:
418.44
MOL File:
66085-59-4.mol
MSDS File:
SDS
Modify Date:
2024/8/21 22:41:43
Request For Quotation

Nimodipine Properties

Melting point 125°C
Boiling point 536.21°C (rough estimate)
Density 1.3268 (rough estimate)
refractive index 1.6500 (estimate)
storage temp. 2-8°C
solubility methanol: 62.5 mg/mL
form solid
pka 2.77±0.70(Predicted)
color white
Merck 14,6551
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey UIAGMCDKSXEBJQ-UHFFFAOYSA-N
CAS DataBase Reference 66085-59-4(CAS DataBase Reference)
NIST Chemistry Reference Nimodipine(66085-59-4)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P501
Hazard Codes  Xn
Risk Statements  20/21/22-48/22
Safety Statements  36
WGK Germany  1
RTECS  US7975500
HazardClass  IRRITANT
HS Code  29333990
Toxicity LD50 in mice, rats (mg/kg): 3562, 6599 orally; 33, 16 i.v. (Schlüter)
NFPA 704
0
1 0

Nimodipine price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) PHR1293 Nimodipine Pharmaceutical Secondary Standard; Certified Reference Material 66085-59-4 1G ₹8107.93 2022-06-14 Buy
Sigma-Aldrich(India) N149 Nimodipine 66085-59-4 100MG ₹9959 2022-06-14 Buy
Sigma-Aldrich(India) N149 Nimodipine 66085-59-4 500MG ₹37086.45 2022-06-14 Buy
Sigma-Aldrich(India) 482200 Nimodipine - CAS 66085-59-4 - Calbiochem An L-type Ca2+ channel blocker. 66085-59-4 25MG ₹8110 2022-06-14 Buy
TCI Chemicals (India) N0896 Nimodipine 66085-59-4 1G ₹9000 2022-05-26 Buy
Product number Packaging Price Buy
PHR1293 1G ₹8107.93 Buy
N149 100MG ₹9959 Buy
N149 500MG ₹37086.45 Buy
482200 25MG ₹8110 Buy
N0896 1G ₹9000 Buy

Nimodipine Chemical Properties,Uses,Production

Description

Nimodipine is a cerebral vasodilating calcium antagonist related to nifedipine. It is indicated for the prophylaxis and treatment of neurological deficits due to cerebral vasospasm after subarachnoid hemorrhage.

Chemical Properties

Crystalline Solid

Uses

Nimodipine has been used:

  • as a L-type calcium channel (LTCC) inhibitor, to evaluate its neuroprotective activity in the vibrosections
  • as a standard, in the enantioseparation of chiral drugs by high performance liquid chromatography (HPLC)
  • in the pharmacological studies for the measurement of spine voltage escape

Definition

ChEBI: A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.

General Description

Nimodipine, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)- 3,5-pyridinedicarboxylic acid 2-methoxyethyl1-methylethyl ester (Nimotop), is another dihydropyridinecalcium channel blocker but differs in that it dilatesthe cerebral blood vessels more effectively than do the otherdihydropyridine derivatives. This drug is indicated for treatmentof subarachnoid hemorrhage-associated neurologicaldeficits.

Biological Activity

L-type Ca 2+ channel blocker.

Nimodipine Preparation Products And Raw materials

Raw materials

Isopropyl acetoacetate (2-METHYL-1H-INDOL-3-YL)-OXO-ACETIC ACID ETHYL ESTER Ethanol 2-Methoxyethanol 3-Nitrobenzaldehyde
Crotonic acid 2-Methoxyethyl acetoacetate Ammonium hydroxide
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Preparation Products

NIMODIPINE RELATED COMPOUND B (50 MG) (BIS(2-METHOXYETHYL) 2,6-DIMETHYL-4-(3-NITROPHE-NYL)-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE) (AS)

Nimodipine Suppliers

Global( 406)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Laksh Finechem Pvt.Ltd. +91-9978522233 +91-78522233 Gujarat, India 55 58 Inquiry
GLP Pharma Standards +91 9866074638 Hyderabad, India 1644 58 Inquiry
Vivimed Labs Ltd +914066086608 Telangana, India 61 58 Inquiry
Rivashaa Agrotech Biopharma Pvt. Ltd. +91-26463395 +91-7926462688 Gujarat, India 1615 58 Inquiry
Biophore India Pharmaceuticals Pvt Ltd +91-9100031592 +91-9030907714 Telangana, India 134 58 Inquiry
DASAMI LAB PRIVATE LTD +91 91728 65326 New Delhi, India 17 58 Inquiry
BIOPHORE INDIA PHARMACEUTICALS PVT LTD +91-4047474545 New Delhi, India 105 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6778 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
Supplier Advantage
Laksh Finechem Pvt.Ltd. 58
GLP Pharma Standards 58
Vivimed Labs Ltd 58
Rivashaa Agrotech Biopharma Pvt. Ltd. 58
Biophore India Pharmaceuticals Pvt Ltd 58
DASAMI LAB PRIVATE LTD 58
BIOPHORE INDIA PHARMACEUTICALS PVT LTD 58
CLEARSYNTH LABS LTD. 58
TCI Chemicals (India) Pvt. Ltd. 58
SynZeal Research Pvt Ltd 58

Related articles

Nimodipine Spectrum

Nimodipine(66085-59-4)1HNMR

66085-59-4(Nimodipine)Related Search:

Nitrendipine Nisoldipine Nimodipine Impurity 5 NIMODIPINE RELATED COMPOUND B (50 MG) (BIS(2-METHOXYETHYL) 2,6-DIMETHYL-4-(3-NITROPHE-NYL)-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE) (AS) 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid bis(1-methylethyl) ester
Amlodipine Nifedipine 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-Methyl Ester EPN Nimodipine
DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE 3-Phenylglutaric acid Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Ethyl 3-(ethylamino)crotonate Diethyl2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate
dimethyl 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate M-NIFEDIPINE 3-(3-NITRO-PHENYL)-PROPIONIC ACID ETHYL ESTER
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1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-isopropyl 5-(2-methoxyethyl) ester 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-(2-methoxyethyl) 5-(1-methylethyl) ester Nimodipine,1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl 1-methylethyl ester, Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridine Nimodipime Isopropyl 2-methoxyethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Nimodipine (125 mg) NiModipine(NiMotop) 1,4-Dihydro-2,6-diMethyl-4-(3-nitrophenyl)- Isopropyl 2-Methoxyethyl 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate 3-isopropyl 5-(2-Methoxyethyl) 2,6-diMethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid- 3-(2-methoxyethyl) 5-(1-methylethyl) ester 1-methylethyl 2-(methyloxy)ethyl 2,6-dimethyl-4-(3-nitroph 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid O3-isopropyl O5-(2-methoxyethyl) ester Nimodipine (USAN/INN) O3-isopropyl O5-(2-methoxyethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Nimodipine, >=99% NIMODIPINE CALCIUM CHANNEL ANTAG NIMODIPINE ASSAY STANDARD BP(CRM STANDARD) NIMODIPINE BP STANDARD(CRM STANDARD) NIMODIPINE EPN(CRM STANDARD) NIMODIPINE MM(CRM STANDARD) inedicarboxylate isopropyl2-methoxyethyl1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyrid 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 1-methylethyl ester O5-(2-Methoxyethyl) O3-propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5 pyridinedicarboxylic acid 2-methyloxyethyl 1-methylethyl ester NIMODIPINE PERIPLUM ADMON 1,4-DIHYDRO-2,6-DIMETHYL-4-(3'-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID 2-METHOXYETHYL-1-METHYLETHYL ESTER 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID 2-METHOXYETHYL 1-METHYLETHYL ESTER 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID 2-METHYLOXYETHYL 1-METHYLETHYL ESTER isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate BAY E 9736 Bay e 9736, Admon, Nimotop, periplum NIMODIPINE(PATENT-NOSUPPLY) Nimodipin 2，6-Dimethyl-4-(3-nitrophenyl)-1，4-dihydro-3，5-pyridinedicarboxylic acid 2-methoxyethyl 1-methylethyl ester 1,4-Dihydro-2,6-dimethyl-4-(3-ni-trophenyl)-3,5-pyridinedicarboxylicacid ethoxyethyl1-methylethylester Isopropyl 2-methoxyethyl Nimodipine - CAS 66085-59-4 - Calbiochem nimodipine api Nimodipine BP (4R)-2,6-dimethyl-4-(3-nitrophenyl)-3,4-dihydropyridine-3,5-dicarboxylic acid O3-(2-methoxyethyl) ester O5-propan-2-yl ester Nimodipine, 99%, an analogue of the calcium channel blocker nifedipine Nimodipine> Nimodipine CRS Nimodipine for peak identification (R)-3-isopropyl 5-(2-methoxyethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Nimodipine USP/EP/BP NIMODIPINE (BAY-e 9736) NimodipineQ: What is Nimodipine Q: What is the CAS Number of Nimodipine Q: What is the storage condition of Nimodipine Q: What are the applications of Nimodipine Nimodipine (1463858) 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-isopropyl 5-(2-methoxyethyl) ester NIMOTOP 2-methyo-xyethyl 1-methylethyl ester Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate, 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl 1-methylethyl ester