Nimodipine
![Nimodipine Structure](CAS/GIF/66085-59-4.gif)
- CAS No.
- 66085-59-4
- Chemical Name:
- Nimodipine
- Synonyms
- NIMOTOP;2-methyo-xyethyl 1-methylethyl ester;1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-isopropyl 5-(2-methoxyethyl) ester;Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate, 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl 1-methylethyl ester;ADMON;PERIPLUM;Nimodipin;Nimodipime;NIMODIPINE;BAY E 9736
- CBNumber:
- CB1398087
- Molecular Formula:
- C21H26N2O7
- Molecular Weight:
- 418.44
- MOL File:
- 66085-59-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/21 22:41:43
Melting point | 125°C |
---|---|
Boiling point | 536.21°C (rough estimate) |
Density | 1.3268 (rough estimate) |
refractive index | 1.6500 (estimate) |
storage temp. | 2-8°C |
solubility | methanol: 62.5 mg/mL |
form | solid |
pka | 2.77±0.70(Predicted) |
color | white |
Merck | 14,6551 |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
InChIKey | UIAGMCDKSXEBJQ-UHFFFAOYSA-N |
CAS DataBase Reference | 66085-59-4(CAS DataBase Reference) |
NIST Chemistry Reference | Nimodipine(66085-59-4) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302 | |||||||||
Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
Hazard Codes | Xn | |||||||||
Risk Statements | 20/21/22-48/22 | |||||||||
Safety Statements | 36 | |||||||||
WGK Germany | 1 | |||||||||
RTECS | US7975500 | |||||||||
HazardClass | IRRITANT | |||||||||
HS Code | 29333990 | |||||||||
Toxicity | LD50 in mice, rats (mg/kg): 3562, 6599 orally; 33, 16 i.v. (Schlüter) | |||||||||
NFPA 704 |
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Nimodipine price More Price(6)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | PHR1293 | Nimodipine Pharmaceutical Secondary Standard; Certified Reference Material | 66085-59-4 | 1G | ₹8107.93 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | N149 | Nimodipine | 66085-59-4 | 100MG | ₹9959 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | N149 | Nimodipine | 66085-59-4 | 500MG | ₹37086.45 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 482200 | Nimodipine - CAS 66085-59-4 - Calbiochem An L-type Ca2+ channel blocker. | 66085-59-4 | 25MG | ₹8110 | 2022-06-14 | Buy |
TCI Chemicals (India) | N0896 | Nimodipine | 66085-59-4 | 1G | ₹9000 | 2022-05-26 | Buy |
Nimodipine Chemical Properties,Uses,Production
Description
Nimodipine is a cerebral vasodilating calcium antagonist related to nifedipine. It is indicated for the prophylaxis and treatment of neurological deficits due to cerebral vasospasm after subarachnoid hemorrhage.
Chemical Properties
Crystalline Solid
Uses
Nimodipine has been used:
- as a L-type calcium channel (LTCC) inhibitor, to evaluate its neuroprotective activity in the vibrosections
- as a standard, in the enantioseparation of chiral drugs by high performance liquid chromatography (HPLC)
- in the pharmacological studies for the measurement of spine voltage escape
Definition
ChEBI: A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.
General Description
Nimodipine, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)- 3,5-pyridinedicarboxylic acid 2-methoxyethyl1-methylethyl ester (Nimotop), is another dihydropyridinecalcium channel blocker but differs in that it dilatesthe cerebral blood vessels more effectively than do the otherdihydropyridine derivatives. This drug is indicated for treatmentof subarachnoid hemorrhage-associated neurologicaldeficits.
Biological Activity
L-type Ca 2+ channel blocker.
Nimodipine Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
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Laksh Finechem Pvt.Ltd. | +91-9978522233 +91-78522233 | Gujarat, India | 55 | 58 | Inquiry |
GLP Pharma Standards | +91 9866074638 | Hyderabad, India | 1644 | 58 | Inquiry |
Vivimed Labs Ltd | +914066086608 | Telangana, India | 61 | 58 | Inquiry |
Rivashaa Agrotech Biopharma Pvt. Ltd. | +91-26463395 +91-7926462688 | Gujarat, India | 1615 | 58 | Inquiry |
Biophore India Pharmaceuticals Pvt Ltd | +91-9100031592 +91-9030907714 | Telangana, India | 134 | 58 | Inquiry |
DASAMI LAB PRIVATE LTD | +91 91728 65326 | New Delhi, India | 17 | 58 | Inquiry |
BIOPHORE INDIA PHARMACEUTICALS PVT LTD | +91-4047474545 | New Delhi, India | 105 | 58 | Inquiry |
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
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