2-Methoxyethanol
- CAS No.
- 109-86-4
- Chemical Name:
- 2-Methoxyethanol
- Synonyms
- H2O;AMYL ALCOHOL;ETHYLENE GLYCOL MONOMETHYL ETHER;METHOXYETHANOL;DISTILLED WATER;Egme;METHYL CELLOSOLVE;GLYCOL MONOMETHYL ETHER;Methyl glycol;EGM
- CBNumber:
- CB4852791
- Molecular Formula:
- C3H8O2
- Molecular Weight:
- 76.09
- MOL File:
- 109-86-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/27 20:28:20
| Melting point | -85 °C |
|---|---|
| Boiling point | 124-125 °C(lit.) |
| Density | 0.965 g/mL at 25 °C(lit.) |
| vapor density | 2.62 (vs air) |
| vapor pressure | 6.17 mm Hg ( 20 °C) |
| refractive index |
n |
| Flash point | 115 °F |
| storage temp. | Store at +5°C to +30°C. |
| solubility |
Very soluble in acetone, dimethylsulfoxide, and 95% ethanol (quoted, Keith and Walters, 1992). Miscible with N,N-dimethylformamide, ether, and glycerol (Windholz et al., 1983). |
| pka | 15.7(at 25℃) |
| form | Liquid |
| color | green cap |
| Relative polarity | 1 |
| PH Range | 5- 7 at 25 °C |
| Odor | Mild ethereal. |
| explosive limit | 2.5-20%(V) |
| Water Solubility | SOLUBLE |
| λmax |
λ: 213 nm Amax: 1.00 λ: 240 nm Amax: 0.20 λ: 260 nm Amax: 0.05 λ: 300-400 nm Amax: 0.01 |
| Merck | 14,6038 |
| BRN | 1731074 |
| Henry's Law Constant | (x 10-2 atm?m3/mol): 4.41, 3.63, 11.6, 3.09, and 3.813 at 10, 15, 20, 25, and 30 °C, respectively (EPICS, Ashworth et al., 1988) |
| Dielectric constant | 15.8（20℃） |
| Exposure limits | TLV-TWA skin 5 ppm (15.5 mg/m3) (ACGIH), 25 ppm (77.5 mg/m3) (OSHA). |
| Stability | Stable, but contact with air may lead to the formation of explosive peroxides. A peroxide test should be carried out before this material is used if it has been exposed to air for some time, especially if it is to be purified by distillation. Contact with strong oxidizing agents may cause fire or explosion. Incompatible with strong bases, ac |
| InChIKey | XNWFRZJHXBZDAG-UHFFFAOYSA-N |
| LogP | -0.77 at 20℃ |
| CAS DataBase Reference | 109-86-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Ethanol, 2-methoxy-(109-86-4) |
| EPA Substance Registry System | 2-Methoxyethanol (109-86-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H226-H302+H312+H332-H360FD-H370-H373 | |||||||||
| Precautionary statements | P210-P280-P301+P312-P303+P361+P353-P304+P340+P312-P308+P311 | |||||||||
| Hazard Codes | T,F,C | |||||||||
| Risk Statements | 60-61-10-20/21/22-39/23/24/25-23/24/25-11-35-34-36/38 | |||||||||
| Safety Statements | 53-45-36/37-16-26-23-36/37/39 | |||||||||
| RIDADR | UN 1188 3/PG 3 | |||||||||
| OEB | C | |||||||||
| OEL | TWA: 0.1 ppm (0.3 mg/m3) [skin] | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | ZC0110000 | |||||||||
| F | 10 | |||||||||
| Autoignition Temperature | 548 °F | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29332990 | |||||||||
| Toxicity | LD50 in rats, guinea pigs (mg/kg): 2460, 950 orally (Smyth); LC50 (7 hr in air) in mice: 4.6 mg/l (Werner) | |||||||||
| IDLA | 200 ppm | |||||||||
| NFPA 704 |
|
2-Methoxyethanol price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 88907 | 2-Methoxyethanol analytical standard | 109-86-4 | 1ML | ₹4449.08 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1544 | 2-Methoxyethanol Pharmaceutical Secondary Standard; Certified Reference Material | 109-86-4 | 3X1.2ML | ₹9103.83 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 88907 | 2-Methoxyethanol analytical standard | 109-86-4 | 5ML | ₹16486.48 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 360503 | 2-Methoxyethanol contains 50?ppm BHT as stabilizer, ACS reagent, ≥99.3% | 109-86-4 | 500ML | ₹5001.15 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 360503 | 2-Methoxyethanol contains 50?ppm BHT as stabilizer, ACS reagent, ≥99.3% | 109-86-4 | 1L | ₹9277.03 | 2022-06-14 | Buy |
2-Methoxyethanol Chemical Properties,Uses,Production
Description
2-Methoxyethanol (2-ME), also known as methoxyethanol or ethylene glycol monomethyl ether, is a glycol ether that has been known since the 1920s, but its use significantly increased in the 1970s. Cellosolve was a solvent product containing glycol ethers and registered in the 1920s by Carbide and Carbon Chemicals Corp. Glycol ethers are derived from either ethylene oxide (E-series) or propylene oxide (p-series) combined with an alcohol. Methoxyethanol is an E-series glycol ether derived from methanol and ethylene oxide. Other commonly used glycol ethers include ethoxyethanol, butoxyethanol, and methoxypropanol. Use of methoxyethanol has declined in recent years due to risk management procedures and replacement by other substances.
Chemical Properties
2-Methoxyethanol is a colorless liquid with a slight ethereal odor. The Odor Threshold is 0.92.3 ppm. It is miscible with water and with aliphatic and aromatic hydrocarbons. It is a solvent for essential oils, lignin, dammar, Elemi Essential Oil, ester gum, kauri, mastic, rosin, sandarac resin, shellac, Zanzibar, nitrocellulose, cellulose acetate, alcohol-soluble dyes and many synthetic resins. Its solvency far cellulose esters is augmented when a ketone or a halogenated hydrocarbon i s added. The uses for 2-Methoxyethanol are as a solvent in quick-drying varnishes and enamels, in conjunction with aliphatic, aromatic and halogenated hydrocarbons, alcohols and ketones; in solvent mixtures and thinners for lacquers and dopes; in the manufacture of synthetic resin plasticizers and as a penetrating and leveling agent in dyeing processes, especially in the dyeing of leather, animal and vegetable fibers. Other uses are as o fixative in perfumes and as a solvent in odorless nail-polish lacquers. 2-Methoxyethanol should not be added to nitrocellulose lacquers containing coumarone resins or ester gum because it will cause incompatibility between these substances.
Physical properties
Colorless liquid with a mild, ether-like odor. Experimentally determined detection and recognition odor threshold concentrations were <300 μg/m3 (<96 ppbv) and 700 μg/m3 (220 ppbv), respectively (Hellman and Small, 1974).
Uses
2-Methoxyethanol is considered a non-comedogenic raw material. It is used as a solvent in nail products and as a stabilizer in cosmetic emulsions. It is able to penetrate the skin and may cause skin irritation.
Definition
ChEBI: 2-methoxyethanol is a hydroxyether that is ethanol substituted by a methoxy group at position 2. It has a role as a protic solvent and a solvent.
Preparation
From Methanol Plus Ethylene glycol, by heating under pressure.
General Description
A clear colorless liquid. Flash point of 110°F. Less dense than water. Vapors are heavier than air.
Air & Water Reactions
Flammable. Water soluble.
Reactivity Profile
2-Methoxyethanol is incompatible with oxygen and strong oxidizing agents. Contact with bases may result in decomposition. Incompatible with acid chlorides and acid anhydrides. . 2-Methoxyethanol forms explosive peroxides.
Hazard
Toxic by ingestion and inhalation. Moderate fire risk. Toxic by skin absorption. Questionable carcinogen.
Health Hazard
2-Methoxyethanol is a teratogen and a chronic inhalation toxicant. The target organs are blood, kidney,and the central nervous system. In addi tion to inhalation, the other routes of expo sure are absorption through the skin, and ingestion. Animal studies indicated that over-exposure to this compound produced anemia, hematuria, and damage to the testes.In humans, inhalation of EGME vapors cancause headache, drowsiness, weakness, irrita tion of the eyes, ataxia, and tremor. The acuteinhalation toxicity, however, is low and anytoxic effect may be felt at a concentration ofabout 25–30 ppm in air
The oral and dermal toxicities of thiscompound in test animals were found to belower than the inhalation toxicity. Ingestioncan produce an anesthetic effect and in alarge dosage can be fatal. An oral intake ofabout 200 mL may cause death to humans.
LC50 value (mice): 1480 ppm/7 h,
LD50 value (rabbits): 890 mg/kg
EGME is a teratogen exhibiting fetotoxi city, affecting the fertility and the litter size,and causing developmental abnormalities inthe urogenital and musculoskeletal systemsin test animals.
Fire Hazard
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Safety Profile
Moderately toxic to humans by ingestion. Moderately toxic experimentally by ingestion, inhalation, shin contact, intraperitoneal, and intravenous routes. Human systemic effects by inhalation: change in motor activity, tremors, and convulsions. Experimental teratogenic and reproductive effects. A skin and eye irritant. Mutation data reported. When used under conditions that do not require the application of heat, thts material probably presents little hazard to health. However, in the manufacture of fused collars which require pressing with a hot iron, cases have been reported showing disturbance of the hemopoietic system with or without neurologcal signs and symptoms. The blood picture may resemble that produced by exposure to benzene. Two cases reported had severe aplastic anemia with tremors and marked mental dullness. The persons affected had been exposed to vapors of methyl "Cellosolve," ethanol, methanol, ethyl acetate, and petroleum naphtha. flame. A moderate explosion hazard. Can react with oxidizing materials to form explosive peroxides. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes. See also GLYCOL ETHERS. Flammable liquid when exposed to heat or
Potential Exposure
2-Methoxyethanol is used as a jet fuel additive; solvent for protective coating; and in chemical synthesis. Ethylene glycol ethers are used as solvents for resins used in the electronics industry, lacquers, paints, varnishes, gum, perfume; dyes and inks; and as a constituent of painting pastes, cleaning compounds; liquid soaps; cosmetics, nitrocellulose, and hydraulic fluids.
Carcinogenicity
There are no experimental carcinogenicity or cancer epidemiology data relating to this chemical , but some short-term test data are available and are summarized in the section on genetic and related cellular effects.
Environmental Fate
Photolytic. Grosjean (1997) reported an atmospheric rate constant of 1.25 x 10-11
cm3/molecule?sec at 298 K for the reaction of methyl cellosolve and OH radicals. Based on an
atmospheric OH concentration of 1.0 x 106 molecule/cm3, the reported half-life of methyl
cellosolve is 0.64 d (Grosjean, 1997).
Chemical/Physical. At an influent concentration of 1,000 mg/L, treatment with GAC resulted in
an effluent concentration of 342 mg/L. The adsorbability of the carbon used was 132 mg/g carbon
(Guisti et al., 1974).
Shipping
UN1188 Ethylene glycol monomethyl ether, Hazard Class: 3; Labels: 3-Flammable liquid
Purification Methods
Peroxides can be removed by refluxing with stannous chloride or by filtration under slight pressure through a column of activated alumina. 2-Methoxyethanol can be dried with K2CO3, CaSO4, MgSO4 or silica gel, then distilled from sodium. Aliphatic ketones (and water) can be removed by making the solvent 0.1% in 2,4-dinitrophenylhydrazine and allowing to stand overnight with silica gel before fractionally distilling. [Beilstein 1 IV 2375.]
Incompatibilities
Vapors may form explosive mixture with air. Heat or oxidizers may cause the formation of unstable peroxides. Attacks many metals. Strong oxidizers may cause fire and explosions. Strong bases cause decomposition and the formation of toxic gas. Attacks some plastics, rubber and coatings. May accumulate static electrical charges, and may cause ignition of its vapors.
Waste Disposal
Concentrated waste containing no peroxides: discharge liquid at a controlled rate near a pilot flame. Concentrated waste containing peroxides: perforation of a container of the waste from a safe distance followed by open burning.
2-Methoxyethanol Preparation Products And Raw materials
Raw materials
1of2
chevron_rightPreparation Products
1of4
chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| Advance Petrochemicals Ltd | +91-9081998855 +91-7573006525 | Gujarat, India | 11 | 58 | Inquiry |
| Swastik Oil | +91-9426313461 +91-9426313461 | Gujarat, India | 13 | 58 | Inquiry |
| RYZE CHEMIE | +91-9702966440 +91-9702966440 | Maharashtra, India | 335 | 58 | Inquiry |
| Labort Fine Chem Pvt,. Ltd. | 91-261-2472670 | Gujarat, India | 34 | 58 | Inquiry |
| Advance Petrochemicals Limited | 08046030618 | Ahmedabad, India | 9 | 58 | Inquiry |
| Swastik Oil Products Mfg. Co. Navsari | +91 22 24130398 | Mumbai, India | 1 | 58 | Inquiry |
| Orbit Lifescience Pvt., Ltd. | 91-22-61113200 | Mumbai, India | 206 | 58 | Inquiry |
| Laffans Petrochemicals Limited | 09820085810 | Mumbai, India | 14 | 58 | Inquiry |
| HiMedia Laboratories | 91-22-61471919 | Maharashtra, India | 1843 | 58 | Inquiry |