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Nisoldipine

Nisoldipine Structure
CAS No.
63675-72-9
Chemical Name:
Nisoldipine
Synonyms
Sular;NisoL;SYSCOR;Syseor;Nisocor;NORVASC;Nikameal;ZADIPINA;BAYMYCARD;Nisoldipin
CBNumber:
CB5147166
Molecular Formula:
C20H24N2O6
Molecular Weight:
388.41
MOL File:
63675-72-9.mol
MSDS File:
SDS
Modify Date:
2023/12/28 18:13:10
Request For Quotation

Nisoldipine Properties

Melting point 147-148°C
Boiling point 503.3±50.0 °C(Predicted)
Density 1.205±0.06 g/cm3(Predicted)
storage temp. room temp
solubility DMSO: >10mg/mL
pka 2.67±0.70(Predicted)
form powder
color yellow
Merck 14,6565
InChIKey VKQFCGNPDRICFG-UHFFFAOYSA-N
CAS DataBase Reference 63675-72-9(CAS DataBase Reference)
NIST Chemistry Reference Nisoldipine(63675-72-9)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P501
Hazard Codes  Xn
Risk Statements  20/21/22
Safety Statements  36
WGK Germany  3
RTECS  US7975600
HS Code  2933399090
NFPA 704
0
3 0

Nisoldipine price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) N0165 Nisoldipine ≥98% (HPLC) 63675-72-9 10MG ₹8540.93 2022-06-14 Buy
Sigma-Aldrich(India) N0165 Nisoldipine ≥98% (HPLC) 63675-72-9 50MG ₹35289.5 2022-06-14 Buy
TCI Chemicals (India) N0900 Nisoldipine 63675-72-9 1G ₹9700 2022-05-26 Buy
TCI Chemicals (India) N0900 Nisoldipine 63675-72-9 5G ₹14500 2022-05-26 Buy
Product number Packaging Price Buy
N0165 10MG ₹8540.93 Buy
N0165 50MG ₹35289.5 Buy
N0900 1G ₹9700 Buy
N0900 5G ₹14500 Buy

Nisoldipine Chemical Properties,Uses,Production

Description

Nisoldipine D4 is another long-acting dihydropyridine calcium channel blocker effective in the treatment of hypertension and angina pectoris. It is reported to have little or no cardiodepressive activity and to be more effective than nifedipine in reducing blood pressure in hypertensives. Nisoldipine has also been shown to be effective in the management of congestive heart failure. Reduction in dosage is necessary in patients with hepatic, but not renal impairment.

Chemical Properties

Nisoldipine D4 is Light Tan Crystals

Uses

Labeled Nisoldipine, intended for use as an internal standard for the quantification of Nisoldipine by GC- or LC-mass spectrometry.

Definition

ChEBI: A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a methoxycarbonyl group at position 3, an o-nitrophenyl group at position 4, and an isobutoxycarbonyl group at position 5. The racemate, calcium channel blocker, is used in the treatment of hypertension and angina pectoris.

General Description

In vitro studies show that the effects ofnisoldipine, 1,4-dihydro-2, 6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinecarboxylic acid methyl 2-methylpropyl ester(Sular), on contractile processes are selective, with greaterpotency on vascular smooth muscle than on cardiac muscle.
Nisoldipine is highly metabolized, with five majormetabolites identified. As with most of the dihydropyridines,the cytochrome P450 (CYP) 3A4 isozyme is mainlyresponsible for the metabolism of nisoldipine. The majorbiotransformation pathway appears to involve the hydroxylationof the isobutyl ester side chain. This particular metabolitehas approximately 10% of the activity of the parentcompound.

Nisoldipine Preparation Products And Raw materials

Raw materials

Methyl 3-aminocrotonate 2-Nitrobenzaldehyde Isobutyl acetoacetate nifedipine iMpurity C Nifedipine
Isobutyl 2-(2-Nitro-Benzylidene)Acetoacetate Nicardipine 2,3-Diamino-2,3-dimethylbutane methyl 3-aminocrotonate
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Preparation Products

Nisoldipine Suppliers

Global( 371)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Hetero Drugs Limited +91-4023704923 +91-4023704923 Telangana, India 296 58 Inquiry
Orchid Pharma Ltd. (Formerly Known as Orchid Chemicals and Pharmaceuticals Ltd.) +91-4428244254 +91-4428244254 Tamil Nadu, India 28 58 Inquiry
Alembic Pharmaceuticals Limited +91-2652280880 +91-2652280550 Gujarat, India 115 58 Inquiry
Alfa Omega Pharma +91-8050045945 +91-9972665399 Maharashtra, India 126 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
CLEANCHEM LABORATORIES LLP +91 98921 69560 New Delhi, India 326 58 Inquiry
Euroasia Trans Continental +91 22 56349035-36 New Delhi, India 519 47 Inquiry
Indogulf Group 91-22-23455220 Maharashtra, India 249 58 Inquiry
ORCHID PHARMA LIMITED +91–44–2744 4471/72/73/74/75/76/77/78 New Delhi, India 32 58 Inquiry
BIOPHORE INDIA PHARMACEUTICALS PVT. LTD. +91-4047474545 New Delhi, India 38 58 Inquiry
Supplier Advantage
Hetero Drugs Limited 58
Orchid Pharma Ltd. (Formerly Known as Orchid Chemicals and Pharmaceuticals Ltd.) 58
Alembic Pharmaceuticals Limited 58
Alfa Omega Pharma 58
Pharma Affiliates 58
CLEANCHEM LABORATORIES LLP 58
Euroasia Trans Continental 47
Indogulf Group 58
ORCHID PHARMA LIMITED 58
BIOPHORE INDIA PHARMACEUTICALS PVT. LTD. 58

Nisoldipine Spectrum

Nisoldipine(63675-72-9)1HNMR

63675-72-9(Nisoldipine)Related Search:

Dimethyl sulfoxide Dimethyl sulfide Dimethyl fumarate 2,6-Lutidine Dimethyl sebacate
Dimethyl sulfate Dimethyl carbonate 2,5-PYRIDINEDICARBOXYLIC ACID 4-Nitrobenzoic acid ETHANE
Dihydromyrcenol Quinolinic acid N,N-Dimethylformamide Dimethyl ether Nitrendipine
Nicardipine Nimodipine Doxazosin
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SYSCOR Nisoldipin 1,4-DIHYDRO-2,6-DIMETHYL-4-(2-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID METHYL 2-METHYLPROPYL ESTER Nisoldipine-d6 3-Isobutyl 5-Methyl 2,6-diMethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid-3-methyl 5-(2-methylpropyl) ester (±)-Isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicarboxylate 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-isobutyl ester Nikameal Ninobarucin Nisomynard 3-Methyl 5-(2-Methylpropyl) (4R)-2,6-diMethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Nisoldipine (Sular) 3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-diMethyl-4-(2-nitrophenyl)-, 3-Methyl 5-(2-Methylpropyl)ester Nisoldipine-d4 methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Nisoldipine, >=99% 5-pyridinedicarboxylicacid,1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-met hyl2-methylpropylester BAYMYCARD BAY K 5552 ZADIPINA ISOBUTYL METHYL (- 1,4-DIHYDRO-2,6-DIMETHYL-4-(2-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLATE Baymycard, Norvasc, Syscor, Zadipina, 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid Methyl 2-methylpropyl Ester 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, methyl 2-methylpropyl ester (9CI) Nisocor Sular Syseor 2，6-Dimethyl-4-(2-nitmphenyl)-1，4-dihydro-3，5-pyridinedicarboxylic acid methyl 2-methylpropyl ester NORVASC NISOLDIPINE NISOLIDIPINE Nisoldipine> Nisoldipine Nisoldipine NisoL 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid Isobutyl Methyl Ester Nisoldipine USP/EP/BP NisoldipineQ: What is Nisoldipine Q: What is the CAS Number of Nisoldipine Q: What is the storage condition of Nisoldipine Q: What are the applications of Nisoldipine hexakis(dihydrogen phosphate) Nisoldipine(BAY-k 5552 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid O3-methyl ester O5-(2-methylpropyl) ester 63675-72-9 C20H18N2O6D6 C20H24N2O6 Calcium channel Cardiovascular APIs Active Pharmaceutical Ingredients All Inhibitors Inhibitors Intermediates & Fine Chemicals Pharmaceuticals