Nifedipine
- CAS No.
- 21829-25-4
- Chemical Name:
- Nifedipine
- Synonyms
- Procardia;diMethyl 2,6-diMethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;ADALAT;Orix;Anifed;Oxcord;CITILAT;ADALATE;NIFELAT;bay1040
- CBNumber:
- CB6260129
- Molecular Formula:
- C17H18N2O6
- Molecular Weight:
- 346.33
- MOL File:
- 21829-25-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/15 13:17:26
| Melting point | 171-175 °C |
|---|---|
| Boiling point | 481.08°C (rough estimate) |
| Density | 1.2109 (rough estimate) |
| refractive index | 1.5486 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble |
| form | powder |
| pka | pKa -0.9/>13(DMF,t undefined) (Uncertain) |
| color | yellow |
| Water Solubility | <0.1 g/100 mL at 19.5 ºC |
| Merck | 14,6528 |
| BCS Class | 2 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions are not stable and must be used within one working day. |
| InChIKey | CYCWGQFQPAYBHG-UHFFFAOYSA-N |
| CAS DataBase Reference | 21829-25-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Nifedipine(21829-25-4) |
| EPA Substance Registry System | Dimethyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate (21829-25-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | US7975000 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29333990 | |||||||||
| Toxicity | LD50 in mice, rats (mg/kg): 494, 1022 orally; 4.2, 15.5 i.v. (Vater) | |||||||||
| NFPA 704 |
|
Nifedipine price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | N7634 | Nifedipine ≥98% (HPLC), powder | 21829-25-4 | 1G | ₹7263.58 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | N7634 | Nifedipine ≥98% (HPLC), powder | 21829-25-4 | 5G | ₹19528.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | N7634 | Nifedipine ≥98% (HPLC), powder | 21829-25-4 | 10G | ₹29920.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1290 | Nifedipine Pharmaceutical Secondary Standard; Certified Reference Material | 21829-25-4 | 1G | ₹7664.1 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | N7634 | Nifedipine ≥98% (HPLC), powder | 21829-25-4 | 25G | ₹52988.38 | 2022-06-14 | Buy |
Nifedipine Chemical Properties,Uses,Production
Chemical Properties
Yellow Crystalline Solid
Uses
Nifedipine is used for preventing and relieving angina pectoris attacks, for hypertension, and as an ingredient in combination therapy for chronic cardiac insufficiency.
World Health Organization (WHO)
Nifedipine is a dihydropyridine calcium channel blocker. It is listed in the WHO Model List of Essential Drugs. The 10mg tablet is retained on the list for short-term treatment of hypertension. Sustained-release preparations are advised for long-term treatment.
General Description
Nifedipine, 1,4-dihydro-2, 6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate dimethyl ester(Adalat, Procardia), is a dihydropyridine derivative thatbears no structural resemblance to the other calcium antagonists.It is not a nitrate, but its nitro group is essential for itsantianginal effect. As a class, the dihydropyridines possessa central pyridine ring that is partially saturated. To this, positions2 and 6 are substituted with an alkyl group that mayplay a role in the agent’s duration of action. In addition, positions3 and 5 are carboxylic groups that must be protectedwith an ester functional group. Depending on the type ofester used at these sites, the agent can be distributed to variousparts of the body. Finally, position 4 requires an aromaticsubstitution possessing an electron-withdrawinggroup (i.e., Cl or NO2) in the ortho and/or meta position.
Air & Water Reactions
Aqueous solutions are very sensitive to light. . Insoluble in water.
Reactivity Profile
Nifedipine is sensitive to light.
Fire Hazard
Flash point data for Nifedipine are not available; however, Nifedipine is probably combustible.
Biological Activity
L-type calcium channel blocker.
Mechanism of action
Nifedipin causes relaxation of smooth musculature, dilation of coronary and peripheral arteries, and reduction of peripheral resistance and arterial blood pressure, and enhances oxygen supply to the heart.
Clinical Use
The prototype of this class, nifedipine, has potent peripheralvasodilatory properties. It inhibits the voltage-dependentcalcium channel in the vascular smooth muscle but has littleor no direct depressant effect on the SA or AV nodes, eventhough it inhibits calcium current in normal and isolated cardiactissues. Nifedipine is more effective in patients whoseanginal episodes are caused by coronary vasospasm and isused in the treatment of vasospastic angina as well as classicangina pectoris. Because of its strong vasodilatory properties,it is used in selected patients to treat hypertension.
Nifedipine Preparation Products And Raw materials
Raw materials
1of2
chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| ANWITA APIS | +919000311012 | Hyderabad, India | 198 | 58 | Inquiry |
| SNECOFRi Pvt Ltd | +91-9032850129 +91-9032850129 | Telangana, India | 404 | 58 | Inquiry |
| GLP Pharma Standards | +91 9866074638 | Hyderabad, India | 1644 | 58 | Inquiry |
| KARPSCHEM LABORATORIES | +91-7249203006 +91-7249203006 | Maharashtra, India | 786 | 58 | Inquiry |
| Ipca Laboratories Ltd | +91-2262105000 +91-2262105000 | Maharashtra, India | 61 | 58 | Inquiry |
| Shilpa Medicare Limited (SML) | +91-8532238704 +91-9320649838 | Karnataka, India | 61 | 58 | Inquiry |
| Sharon Bio Medicine Ltd | +91-9769026333 +91-9821911142 | Mumbai, India | 12 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Alfa Omega Pharma | +91-8050045945 +91-9972665399 | Maharashtra, India | 126 | 58 | Inquiry |
| J.B. Chemicals Pharmaceuticals Ltd. | +91-022-24822222 +91-02224822222 | Mumbai, India | 10 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| ANWITA APIS | 58 |
| SNECOFRi Pvt Ltd | 58 |
| GLP Pharma Standards | 58 |
| KARPSCHEM LABORATORIES | 58 |
| Ipca Laboratories Ltd | 58 |
| Shilpa Medicare Limited (SML) | 58 |
| Sharon Bio Medicine Ltd | 58 |
| Ralington Pharma | 58 |
| Alfa Omega Pharma | 58 |
| J.B. Chemicals Pharmaceuticals Ltd. | 58 |
21829-25-4(Nifedipine)Related Search:
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chevron_rightCAS:21829-25-4
PHARMA-0503 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylicaciddime 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, dimethyl ester 4-(2’-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridin-3,5-dicarbonsaeuredimethy 5-pyridinedicarboxylicacid,1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-dim Adalat CC bay1040 corinfar Dimethyl 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicarboxylate Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate Dimethyl 4-(2-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate dimethyl1,4-dihydro-2,6-dimethyl-4-(2’-nitrophenyl)-3,5-pyridinedicarboxylat fenihidin fenihidine Hexadilat Introcar Kordafen Methyl (4-(2-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate) Nifedicor Nifedin nifedipine(uspgrade) Nifelan Nifensar XL Orix Oxcord Pidilat Procardia XL Sepamit Tibricol