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ChemicalBook > Product Catalog >Pharmaceutical intermediates >Heterocyclic compound >Pyridine compound >Dihydropyridine >DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE

DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE

DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE Structure
CAS No.
632-93-9
Chemical Name:
DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE
Synonyms
Dicarbethoxydihydrocollidine;1,4-Dihydro-3,5-dicarbethoxycollidine;3,5-dicarbethoxy-1,4-dihydrocollidine;3,5-diethoxycarbonyl-1,4-dihydrocollidine;3,5-dicarbethoxy-1,4-dihydrocollidine, DDC;3,5-Bis(ethoxycarbonyl)-1,4-dihydrocollidine;3,5-DIETHOXYCARBONYL-1,4-DIHYDRO-2,4,6-COLLIDINE;Diethyl 1,4-dihydro-s-collidine-3,5-dicarboxylate;3,5-DICARBETHOXY-1,4-DIHYDRO-2,4,6-TRIMETHYLPYRIDINE;3,5-Diethoxycarbonyl-1,4-dihydro-2,4,6-collidine >
CBNumber:
CB7373477
Molecular Formula:
C14H21NO4
Molecular Weight:
267.32
MOL File:
632-93-9.mol
MSDS File:
SDS
Modify Date:
2023/6/8 17:06:35
Request For Quotation

DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE Properties

Melting point 130-132 °C(lit.)
Boiling point 410.51°C (rough estimate)
Density 1.1116 (rough estimate)
refractive index 1.5280 (estimate)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMF: 30 mg/ml; DMF:PBS (pH 7.2); (1:7): 0.125 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml
form powder to crystal
pka 3.53±0.70(Predicted)
color White to Orange to Green
CAS DataBase Reference 632-93-9(CAS DataBase Reference)
EPA Substance Registry System 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,4,6-trimethyl-, diethyl ester (632-93-9)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-37/39
WGK Germany  3
RTECS  US7979375
HS Code  2933.39.9200
NFPA 704
1
2 0

DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 137030 Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate 99% 632-93-9 25G ₹9926.53 2022-06-14 Buy
TCI Chemicals (India) D0558 3,5-Diethoxycarbonyl-1,4-dihydro-2,4,6-collidine min. 98.0 % 632-93-9 1G ₹2100 2022-05-26 Buy
TCI Chemicals (India) D0558 3,5-Diethoxycarbonyl-1,4-dihydro-2,4,6-collidine min. 98.0 % 632-93-9 5G ₹3100 2022-05-26 Buy
TCI Chemicals (India) D0558 3,5-Diethoxycarbonyl-1,4-dihydro-2,4,6-collidine min. 98.0 % 632-93-9 25G ₹5500 2022-05-26 Buy
Product number Packaging Price Buy
137030 25G ₹9926.53 Buy
D0558 1G ₹2100 Buy
D0558 5G ₹3100 Buy
D0558 25G ₹5500 Buy

DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE Chemical Properties,Uses,Production

Description

Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate (DDC) inhibits heme production by inhibiting ferrochelatase, the enzyme that catalyzes the addition of Fe2+ to protoporphyrin IX to create heme B. Chronic DDC administration induces Mallory-Denk body formation, a feature of alcoholic and non-alcoholic hepatitis, and reduces IL-12A methylation in mouse liver.

Chemical Properties

almost white crystalline powder

Uses

Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate was used to induce Mallory-Denk body formation in mice in vivo.

Definition

ChEBI: A dihydropyridine that is 2,4,6-trimethyl-1,4-dihydropyridine substituted by ethoxycarbonyl groups at positions 3 and 5.

Purification Methods

Crystallise the ester from hot EtOH/water mixture. [Beilstein 22 H 147, 22 I 529, 22 II 100, 22 III/IV 1594.]

DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE Suppliers

Global( 92)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6778 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
Hefei TNJ Chemical Industry Co.,Ltd. 0551-65418671 China 34571 58 Inquiry
ANHUI WITOP BIOTECH CO., LTD +8615255079626 China 23556 58 Inquiry
Shaanxi Dideu Medichem Co. Ltd +86-029-89586680 +86-18192503167 China 9030 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 25553 58 Inquiry
LEAP CHEM CO., LTD. +86-852-30606658 China 24738 58 Inquiry
Jilin Chinese Academy of Sciences-yanshen Technology +undefined18143011203 China 42057 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131980 58 Inquiry
Supplier Advantage
TCI Chemicals (India) Pvt. Ltd. 58
Chongqing Chemdad Co., Ltd 58
Hefei TNJ Chemical Industry Co.,Ltd. 58
ANHUI WITOP BIOTECH CO., LTD 58
Shaanxi Dideu Medichem Co. Ltd 58
Dideu Industries Group Limited 58
LEAP CHEM CO., LTD. 58
Jilin Chinese Academy of Sciences-yanshen Technology 58
Aladdin Scientific 58
Amadis Chemical Company Limited 58

DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE Spectrum

DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE(632-93-9)MSDIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE(632-93-9)1HNMRDIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE(632-93-9)IR1DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE(632-93-9)IR2DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE(632-93-9)Raman

632-93-9(DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE)Related Search:

Diethyl pyridine-3,5-dicarboxylate DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE Nimodipine 3,5-Pyridinedicarboxylic acid 2,4,6-Collidine
3,5-PYRIDINEDICARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-4-(3,4,5-TRIMETHOXYPHENYL)-, DIETHYL ESTER 2,6-DIMETHYL-1,4-DIHYDRO-PYRIDINE-3,4,5-TRICARBOXYLIC ACID 3,5-DIETHYL ESTER DIETHYL 1,4-DIHYDRO-2,6-DIMETHYL-4-(4-F& DIETHYL 4-ETHYL-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLATE Diethyl2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate
2,6-Dimethyl-4-(2-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester AURORA 3177 LABOTEST-BB LT00261244 AURORA 3480 diethyl 2,6-dimethyl-4-thiophen-2-yl-1,4-dihydropyridine-3,5-dicarboxylate
DIETHYL 1,4-DIHYDRO-2,6-DIMETHYL-1,4-DIPHENYL-3,5-PYRIDINEDICARBOXYLATE AURORA 4028 3,5-PYRIDINEDICARBOXYLIC ACID, 4-(1,3-BENZODIOXOL-5-YL)-1,4-DIHYDRO-2,6-DIMETHYL-, DIETHYL ESTER
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DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYLPYRIDINE-3,5-DICARBOXYLATE 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER 3,5-DICARBETHOXY-1,4-DIHYDRO-2,4,6-TRIMETHYLPYRIDINE 3,5-DIETHOXYCARBONYL-1,4-DIHYDRO-2,4,6-COLLIDINE 5-pyridinedicarboxylicacid,1,4-dihydro-2,4,6-trimethyl-diethylester Dicarbethoxydihydrocollidine diethyl dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate 3,5-dicarbethoxy-1,4-dihydrocollidine, DDC 1,4-Dihydro-2,4,6-collidine-3,5-dicarboxylic acid diethyl ester 1,4-Dihydro-2,4,6-trimethylpyridine-3,5-dicarboxylic acid diethyl ester 1,4-Dihydro-3,5-dicarbethoxycollidine 3,5-Bis(ethoxycarbonyl)-1,4-dihydrocollidine Diethyl 1,4-dihydro-s-collidine-3,5-dicarboxylate Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate,99% 3,5-dicarbethoxy-1,4-dihydrocollidine Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate,3,5-dicarbethoxy-1,4-dihydrocollidine, DDC Diethyl 1,4-dihydro-2,4,6-triMethyl-3,5-pyridinedicarboxylate, 99% 25GR 1,4-Dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylic Acid Diethyl Ester Diethyl 1,4-Dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,4,6-triMethyl-, 3,5-diethyl ester Diethyl 1,4-dihydro-2,4,6-triMethyl-3,5-pyridinedicarboxylate 99% Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate 3,5-diethoxycarbonyl-1,4-dihydrocollidine DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE (4R)-2,4,6-trimethyl-3,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester 3,5-Diethoxycarbonyl-1,4-dihydro-2,4,6-collidine > DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE ISO 9001：2015 REACH 632-93-9 C14H21NO4 Building Blocks C9 to C46 Heterocyclic Building Blocks Pyridines