2,4,6-Collidine
- CAS No.
- 108-75-8
- Chemical Name:
- 2,4,6-Collidine
- Synonyms
- 2,4,6-TRIMETHYLPYRIDINE;S-COLLIDINE;g-Collidine;2,4,6-Kollidin;246CO;246BD;2,4,6-CoL;SYM COLLIDINE;2,4,6-COLLIDINE;GAMMA-COLLIDINE
- CBNumber:
- CB6852760
- Molecular Formula:
- C8H11N
- Molecular Weight:
- 121.18
- MOL File:
- 108-75-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/29 22:41:02
| Melting point | -43 °C (lit.) |
|---|---|
| Boiling point | 171-172 °C (lit.) |
| Density | 0.917 g/mL at 25 °C (lit.) |
| vapor pressure | 4 hPa (20 °C) |
| refractive index |
n |
| Flash point | 135 °F |
| storage temp. | Store below +30°C. |
| solubility | 35g/l |
| pka | 7.43(at 25℃) |
| form | Liquid |
| color | Clear colorless to yellow |
| Water Solubility | 35 g/L (20 ºC) |
| Sensitive | Hygroscopic |
| Merck | 14,9718 |
| BRN | 107283 |
| Dielectric constant | 1.9（20℃） |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
| LogP | 1.25 at 20℃ |
| CAS DataBase Reference | 108-75-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Pyridine, 2,4,6-trimethyl-(108-75-8) |
| EPA Substance Registry System | 2,4,6-Trimethylpyridine (108-75-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H226-H302+H332-H311-H315-H319-H335 | |||||||||
| Precautionary statements | P210-P280-P301+P312-P303+P361+P353-P304+P340+P312-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 10-20/21/22-36/37/38 | |||||||||
| Safety Statements | 26-36/37-36 | |||||||||
| RIDADR | UN 1992 3/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UU0970000 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29333999 | |||||||||
| Toxicity | LD50 orally in Rabbit: 400 mg/kg | |||||||||
| NFPA 704 |
|
2,4,6-Collidine price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 8.22267 | 2,4,6-Trimethylpyridine for synthesis | 108-75-8 | 50ML | ₹2950 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.22267 | 2,4,6-Trimethylpyridine for synthesis | 108-75-8 | 250ML | ₹7310.01 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.22267 | 2,4,6-Trimethylpyridine for synthesis | 108-75-8 | 1L | ₹26830 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 27690 | 2,4,6-Trimethylpyridine puriss. p.a., ≥99.0% (GC) | 108-75-8 | 100ML | ₹7696.58 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 142387 | 2,4,6-Trimethylpyridine ReagentPlus?, 99% | 108-75-8 | 5ML | ₹214.34 | 2022-06-14 | Buy |
2,4,6-Collidine Chemical Properties,Uses,Production
Chemical Properties
colourless liquid
Uses
2,4,6-Collidine is an reagent used for various synthetic preparations such as the synthesis of methylated pyridines by three-componet catalytic condensation of acetylene, acetone and ammonia.
Definition
Methyl, ethyl, propyl, and trimethyl homologs of pyridine.
General Description
2,4,6-Trimethylpyridine is a pyridine derivative. It has a pK of 7.4. The product can react with trifluoroiodomethane in cyclopentane solution to afford 1:1 complex. This complex was investigated by NMR (Nuclear Magnetic Resonance) spectroscopy. Collidine-buffered osmium tetroxide solutions have been prepared by adding osmium tetroxide solution to it. These solutions have been used as fixative for electron microscopic studies.
2,4,6-Trimethylpyridine can undergo oxidation with potassium permanganate to form 2,4,6-pyridinetricarboxylic acid.
Hazard
Toxic.
Purification Methods
Commercial samples may be grossly impure. Likely contaminants include 3,5-dimethylpyridine, 2,3,6-trimethylpyridine and water. Brown, Johnson and Podall [J Am Chem Soc 76 5556 1954] fractionally distilled 2,4,6-trimethylpyridine under reduced pressure through a 40cm Vigreux column (p 11) and added to 430mL of the distillate slowly, with cooling to 0o, 45g of BF3-diethyl etherate. The mixture was again distilled, and an equal volume of dry *benzene was added to the distillate. Dry HCl was passed into the solution, which was kept cold in an ice-bath, and the hydrochloride was filtered off. It was recrystallised from absolute EtOH (1.5mL/g) to m 286-287o[m 256o(sealed tube), also m 293-294o subliming slowly]. The free base was regenerated by treatment with aqueous NaOH, then extracted with *benzene, dried (MgSO4) and distilled under reduced pressure. Sisler et al. [J Am Chem Soc 75 446 1953] precipitated trimethylpyridine as its phosphate from a solution of the base in MeOH by adding 85% H3PO4, shaking and cooling. The free base was regenerated as above. Garrett and Smythe [J Chem Soc 763 1903] purified the trimethylpyridine via the HgCl2 complex. It is more soluble in cold than hot H2O [the solubility is 20.8% at 6o, 3.5% at 20o, 1.8% at 100o]. Alternatively, purify it by dissolving it in CHCl3, adding solid K2CO3 and Drierite, filtering and fractionally distilling through an 8in helix-packed column. The sulfate has m 205o, and the picrate (from hot H2O) has m 155-156o. [Frank & Meikle J Am Chem Soc 72 4184 1950, Beilstein 20 H 250, 20 I 87, 20 II 164, 20 III/IV 2810, 20/6 V 93.]
2,4,6-Collidine Preparation Products And Raw materials
Raw materials
1of3
chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| SHAKAMBARI AROMATICS PRIVATE LIMITED | +91 9819024666 | Kolkata, India | 13 | 58 | Inquiry |
| REVIN LABS PRIVATE LIMITED | +91-04029881685 +91-9989320685 | Telangana, India | 12 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| Jubilant Ingrevia | +91-1204361000 +91-1204361000 | Uttar Pradesh, India | 142 | 58 | Inquiry |
| Resonance Specialties Limited | +91-2262106053 +91-2268572824 | Maharashtra, India | 21 | 58 | Inquiry |
| Mehta Enterprise | 08068442230Ext 607 | Mumbai, India | 155 | 58 | Inquiry |
| Oceanic Pharmachem Pvt., Ltd. (OPPL) | 91-22-42128600 | Maharashtra, India | 947 | 58 | Inquiry |
| HiMedia Laboratories | 91-22-61471919 | Maharashtra, India | 1843 | 58 | Inquiry |
| Vyas Bio Life Sciences Pvt. Ltd | -65546373 | Hyderabad, India | 1213 | 58 | Inquiry |
108-75-8(2,4,6-Collidine)Related Search:
1of4
chevron_right