Streptonigrin
- CAS No.
- 3930-19-6
- Chemical Name:
- Streptonigrin
- Synonyms
- NIGRIN;5278r.p.;nsc45383;NSC 83950;NSC 56748;valacidin;phaeomycin;BRUNEOMYCIN;AO 50165L302;streptonigran
- CBNumber:
- CB1333569
- Molecular Formula:
- C25H22N4O8
- Molecular Weight:
- 506.46
- MOL File:
- 3930-19-6.mol
- Modify Date:
- 2024/7/2 8:55:00
| Melting point | 301-303℃ |
|---|---|
| Boiling point | 595.12°C (rough estimate) |
| Density | 1.4130 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| storage temp. | 2-8°C |
| solubility | Chloroform:Methanol (1:1): 2 mg/ml |
| form | A solid |
| pka | 6.2-6.4 (1:1 aq dioxane) |
| color | Light brown to brown |
| Merck | 13,8907 |
| BRN | 599390 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P405-P501 | |||||||||
| Hazard Codes | T+ | |||||||||
| Risk Statements | 28 | |||||||||
| Safety Statements | 53-28-36/37/39-45 | |||||||||
| RIDADR | UN 3462 6.1/PG 1 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TJ7350000 | |||||||||
| F | 10-18 | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | II | |||||||||
| Toxicity | LD50 oral in mouse: 2330ug/kg | |||||||||
| NFPA 704 |
|
Streptonigrin price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | S1014 | Streptonigrin from Streptomyces flocculus ≥98% | 3930-19-6 | 1MG | ₹10965.73 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | S1014 | Streptonigrin from Streptomyces flocculus ≥98% | 3930-19-6 | 5MG | ₹43451.55 | 2022-06-14 | Buy |
Streptonigrin Chemical Properties,Uses,Production
Chemical Properties
Brown to red solid. Soluble in polar solvents and alkaline solutions; insoluble in most nonpolar solvents and acid solutions.
Uses
Streptonigrin is an unusual aminoquinone with broad biological activity against bacteria, fungi, nematodes, viruses and tumour cells. Streptonigrin acts as a bioreductive agent, highly dependent on interactions with metal ions, notably iron, and plays an important role in free radical production through redox cycling of NAD(P)H:quinone oxidoreductase (NQO1).
Definition
ChEBI: Complex cytotoxic antibiotic obtained from Streptomyces flocculus or S. rufochronmogenus. It is used in advanced carcinoma and causes leukopenia.
Purification Methods
Streptonigrin is purified by TLC on pH 7-buffered silica gel plates (made from a slurry of Silica Gel 60 and 400mL of 0.05M phosphate buffer pH 7.0) and eluted with 5% MeOH/CHCl3. Material from the extracted band recrystallises from Me2CO or dioxane as almost black plates or needles. It is soluble in pyridine, Me2NCHO, aqueous NaHCO3 (some dec), and slightly soluble in MeOH, EtOH, EtOAc and H2O. It has UV max 248, 375-380nm ( 38,400 and 17,400). [Weinreb et al. J Am Chem Soc 104 536 1982, Rao et al. J Am Chem Soc 85 2532 1963.] Itis antineoplastic and causes severe bone marrow depression [Wilson et al. Antibiot Chemother 11 147 1961].
Streptonigrin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29900 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 26114 | 58 | Inquiry |
| BOC Sciences | 16314854226; +16314854226 | United States | 19743 | 58 | Inquiry |
| changzhou huayang technology co., ltd | +8615250961469 | China | 9821 | 58 | Inquiry |
| Alfa Chemistry | +1-5166625404 | United States | 21317 | 58 | Inquiry |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | China | 20324 | 58 | Inquiry |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | China | 33350 | 58 | Inquiry |
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