Streptonigrin
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- ₹10965.73 - ₹43451.55
- Product name: Streptonigrin
- CAS: 3930-19-6
- MF: C25H22N4O8
- MW: 506.46
- EINECS:223-501-8
- MDL Number:MFCD00063401
- Synonyms:rufocromomycin;streptonigrin from streptomyces flocculus;Streptonigrin, Streptomyces flocculus;Bruneomycin, Nigrin;5-Amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxoquinolin-2-yl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpicolinic acid;5-Amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpicolinic acid;Abbott Crystalline antibiotic;AO 50165L302
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 1MG
- 5MG
- ManufacturerSigma-Aldrich(India)
- Product numberS1014
- Product descriptionStreptonigrin from Streptomyces flocculus ≥98%
- Packaging1MG
- Price₹10965.73
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberS1014
- Product descriptionStreptonigrin from Streptomyces flocculus ≥98%
- Packaging5MG
- Price₹43451.55
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | S1014 | Streptonigrin from Streptomyces flocculus ≥98% | 1MG | ₹10965.73 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | S1014 | Streptonigrin from Streptomyces flocculus ≥98% | 5MG | ₹43451.55 | 2022-06-14 | Buy |
Properties
Melting point :301-303℃
Boiling point :595.12°C (rough estimate)
Density :1.4130 (rough estimate)
refractive index :1.6000 (estimate)
storage temp. :2-8°C
solubility :Chloroform:Methanol (1:1): 2 mg/ml
form :A solid
pka :6.2-6.4 (1:1 aq dioxane)
color :Light brown to brown
Merck :13,8907
BRN :599390
Boiling point :595.12°C (rough estimate)
Density :1.4130 (rough estimate)
refractive index :1.6000 (estimate)
storage temp. :2-8°C
solubility :Chloroform:Methanol (1:1): 2 mg/ml
form :A solid
pka :6.2-6.4 (1:1 aq dioxane)
color :Light brown to brown
Merck :13,8907
BRN :599390
Safety Information
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Description
Streptonigrin is a phenylpyridylquinoline originally isolated from S. flocculus with diverse biological activities. Streptonigrin (2.5-12.5 μM) induces DNA cleavage by calf thymus topoisomerase II in a concentration-dependent manner. It induces phage production in S. typhimurium when used at concentrations ranging from 1 to 10 μg/ml. Streptonigrin (10 μg/ml) inhibits DNA synthesis in and reduces survival of S. typhimurium bacteria. Streptonigrin is bactericidal against E. coli in an iron-dependent manner, an effect that is blocked by the iron chelators deferoxamine and orthophenanthroline. Streptonigrin (40 nM) is cytotoxic to human HT-29 colon carcinoma cells but not to BE colon carcinoma cells in which NAD(P)H:quinone oxidoreductase is not expressed. Streptonigrin (0.001-0.1 μg/ml) inhibits mitosis and induces chromatin breaks in human leukocytes in a concentration-dependent manner. In vivo, streptonigrin (0.05 mg/kg, i.p.) increases the mean survival time in rats infected with Rauscher virus.More related product prices
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