2,6-Di-tert-butyl-4-methylpyridine
- CAS No.
- 38222-83-2
- Chemical Name:
- 2,6-Di-tert-butyl-4-methylpyridine
- Synonyms
- DTBMP;Dibutylmethylpyridine;D2419;AB1003;AC-5133;AC1L40I3;Di-tert-butyl-4-Methylpyr;HVHZEKKZMFRULH-UHFFFAOYSA-N;2,6-Di-t-butyl-4-methylpyridine;2,6-DITERT-BTUYL-4-METHYLPYRIDINE
- CBNumber:
- CB1165928
- Molecular Formula:
- C14H23N
- Molecular Weight:
- 205.34
- MOL File:
- 38222-83-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/13 17:03:25
| Melting point | 33-36 °C (lit.) |
|---|---|
| Boiling point | 233 °C (lit.) |
| Density | 1,476 g/cm3 |
| refractive index |
n |
| Flash point | 183 °F |
| storage temp. | 2-8°C |
| solubility | ethanol: soluble5%, clear to slightly hazy, colorless to dark yellow |
| form | Liquid or Low Melting Solid |
| pka | 6.88±0.10(Predicted) |
| color | brown |
| Water Solubility | Sparingly soluble in water. Soluble in ethanol, acetic acid and diethyl ether. |
| Sensitive | Air & Light Sensitive |
| BRN | 130503 |
| InChIKey | HVHZEKKZMFRULH-UHFFFAOYSA-N |
| CAS DataBase Reference | 38222-83-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 8-10-23 | |||||||||
| HS Code | 29333990 | |||||||||
| NFPA 704 |
|
2,6-Di-tert-butyl-4-methylpyridine price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 249505 | 2,6-Di-tert-butyl-4-methylpyridine 98% | 38222-83-2 | 1G | ₹3117.6 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 249505 | 2,6-Di-tert-butyl-4-methylpyridine 98% | 38222-83-2 | 5G | ₹10348.7 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 249505 | 2,6-Di-tert-butyl-4-methylpyridine 98% | 38222-83-2 | 25G | ₹44003.63 | 2022-06-14 | Buy |
| TCI Chemicals (India) | D2419 | 2,6-Di-tert-butyl-4-methylpyridine min. 98.0 % | 38222-83-2 | 5G | ₹8400 | 2022-05-26 | Buy |
| ALFA India | ALF-L14143-06 | 2,6-Di-tert-butyl-4-methylpyridine, 97% | 38222-83-2 | 5g | ₹7735 | 2022-05-26 | Buy |
2,6-Di-tert-butyl-4-methylpyridine Chemical Properties,Uses,Production
Chemical Properties
light yellow powder
Uses
2,6-Di-tert-butyl-4-methylpyridine is used for the generation of enol triflates from ketones using trifluoromethanesulfonic anhydride. It is also used in the synthesis of 1,2-dihydro-2-silanaphthalene derivatives, as base in PtCl4-catalyzed cyclization reactions of homopropargyl azide derivatives and in diastereoselective synthesis of β-thiomannopyranosides.
Purification Methods
A possible impurity is 2,6-di-tert-butyl-4-neopentylpyridine. Attempts to remove coloured impurities directly by distillation, acid-base extraction or treatment with activated charcoal were unsuccessful. Pure material is obtained by dissolving 0.3mole of the alkylpyridine in pentane (150mL) and introducing it at the top of a cold water jacketed chromatographic column (40 x 4.5cm) (cooling is necessary because the base in pentane reacts exothermically with alumina) containing activated and acidic alumina (300g). The column is eluted with pentane using a 1L constant pressure funnel fitted at the top of the column to provide slight pressure. All the pyridine is obtained in the first two litres of eluent (the progress of elution is monitored by spotting a fluorescent TLC plate and examining under short wave UV light—a dark blue spot is evidence for the presence of the alkylpyridine). Elution is complete in 1hour. Pentane is removed on a rotovap with 90-93% recovery yielding a liquid which solidifies on cooling, m 31-32o, and the base can be distilled. The HPtCl6 salt has m 213-314o(dec), and the CF3SO3H salt has m 202.5-203.5o (from CH2Cl2). [Anderson & Stang Org Synth Coll Vol VII 144 1981, Beilstein 20/6 V 190.]
2,6-Di-tert-butyl-4-methylpyridine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Survival Technologies Pvt Ltd | +91 (22) 4212-8221 | New Delhi, India | 290 | 50 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Reax Chemicals | 08048372701Ext 416 | Hyderabad, India | 4223 | 58 | Inquiry |
| VASIN BIO LIFE SCIENCES PVT LTD | 9491644688 | Hyderabad, India | 2096 | 58 | Inquiry |
| Survival Technologies Private Limited | 08879997937 | Mumbai, India | 153 | 58 | Inquiry |
| TSK Lifesciences | 91-9397306789 | Hyderabad, India | 246 | 58 | Inquiry |
| Suzhou Ryan Pharmachem Technology Co.,Ltd. | +86-512-68780025 +8618962125825 | China | 137 | 58 | Inquiry |
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