Trifluoromethanesulfonic acid
- CAS No.
- 1493-13-6
- Chemical Name:
- Trifluoromethanesulfonic acid
- Synonyms
- TFOH;TRIFLIC ACID;Triflate;TFMSA;trifluoromethanesulfonic;triflic;Trifluoromethanesulf;TRIFLUOROMETHANESULPHONIC ACID;PFC-MS;TRIFLUOROMETHYLSULFONIC ACID
- CBNumber:
- CB7247316
- Molecular Formula:
- CHF3O3S
- Molecular Weight:
- 150.08
- MOL File:
- 1493-13-6.mol
- Modify Date:
- 2024/5/20 14:01:34
| Melting point | -40 °C |
|---|---|
| Boiling point | 162 °C (lit.) |
| Density | 1.696 g/mL at 25 °C (lit.) |
| vapor density | 5.2 (vs air) |
| vapor pressure | 8 mm Hg ( 25 °C) |
| refractive index |
n |
| RTECS | PB2771000 |
| Flash point | None |
| storage temp. | Store below +30°C. |
| solubility | Miscible in H<sub>2</sub>O |
| pka | -14(at 25℃) |
| form | Fuming Liquid |
| Specific Gravity | 1.696 |
| color | slightly brown |
| PH | <1 (H2O) |
| Water Solubility | SOLUBLE |
| Sensitive | Hygroscopic |
| Merck | 14,9676 |
| BRN | 1812100 |
| Stability | Stable. Incompatible with acids, alkalis, metals. |
| InChIKey | ITMCEJHCFYSIIV-UHFFFAOYSA-N |
| LogP | 0.3 at 25℃ |
| CAS DataBase Reference | 1493-13-6(CAS DataBase Reference) |
| NIST Chemistry Reference | CF3SO3H(1493-13-6) |
| EPA Substance Registry System | Methanesulfonic acid, trifluoro- (1493-13-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H290-H302-H314-H335 | |||||||||
| Precautionary statements | P234-P261-P280-P301+P312-P303+P361+P353-P305+P351+P338 | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 21/22-35-10 | |||||||||
| Safety Statements | 26-36/37/39-45 | |||||||||
| RIDADR | UN 3265 8/PG 2 | |||||||||
| WGK Germany | 2 | |||||||||
| F | 3-10 | |||||||||
| Hazard Note | Corrosive/Hygroscopic | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29049020 | |||||||||
| Toxicity | LD50 orally in Rabbit: 1605 mg/kg LD50 dermal Rat > 2000 mg/kg | |||||||||
| NFPA 704 |
|
Trifluoromethanesulfonic acid price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 347817 | Trifluoromethanesulfonic acid ReagentPlus?, ≥99% | 1493-13-6 | 5G | ₹6910.25 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.21166 | Trifluoromethanesulfonic acid for synthesis | 1493-13-6 | 100ML | ₹6990 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 347817 | Trifluoromethanesulfonic acid ReagentPlus?, ≥99% | 1493-13-6 | 25G | ₹23399.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.21166 | Trifluoromethanesulfonic acid for synthesis | 1493-13-6 | 1L | ₹45380 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 347817 | Trifluoromethanesulfonic acid ReagentPlus?, ≥99% | 1493-13-6 | 100G | ₹39056.1 | 2022-06-14 | Buy |
Trifluoromethanesulfonic acid Chemical Properties,Uses,Production
Chemical Properties
Clear very light yellow liquid. Smoke in the air, easy to absorb water to form a hydrate. It is easily soluble in water, releases a lot of heat, and hydrolyzes to generate trifluoromethane (CHF3) and sulfuric acid.
Uses
Trifluoromethanesulfonic acid acts as a catalyst for esterification reactions and an acidic titrant in nonaqueous acid-base titration. It is useful in protonations due to the presence of conjugate base triflate is non nucleophilic. It serves as a deglycosylation agent for glycoproteins. In addition, it is a precursor and a catalyst in organic chemistry. It reacts with acyl halides to prepare mixed triflate anhydrides, which are strong acylating agents used in Friedel-Crafts reactions. It acts as a key starting material for the preparation of ethers and olefins by reacting with alcohols as well as to prepare trifluoromethanesulfonic anhydride by dehydration reaction.
Uses
As a catalyst in Friedel-Crafts type acylation, alkylation and polymerization reactions; as a solvent for ESR; as a nonaqueous strong acid titrant; with trifluoroacetic acid, q.v., in solid-phase peptide synthesis. One of the strongest available monoprotic acids.
Definition
ChEBI: Trifluoromethanesulfonic acid is a one-carbon compound that is methanesulfonic acid in which the hydrogens attached to the methyl carbon have been replaced by fluorines. It is a one-carbon compound and a perfluoroalkanesulfonic acid. It is a conjugate acid of a triflate.
General Description
Trifluoromethanesulfonic acid is a strong organic acid. It can be prepared by reacting bis(trifluoromethylthio)mercury with H2O2. On mixing with HNO3, it affords a nitrating reagent (a nitronium salt). This reagent is useful for the nitration of aromatic compounds. Its dissociation in various organic solvents has been studied.
Safety Profile
A corrosive irritant to the skin, eyes, and mucous membranes. A strong acid. Violent reaction with acyl chlorides or aromatic hydrocarbons evolves toxic hydrogen chloride gas. When heated to decomposition it emits toxic fumes of Fand SOx. See also FLUORIDES.
Trifluoromethanesulfonic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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|---|---|
| GLR Innovations | 58 |
| DAVY CHEM LABS | 58 |
| SURVIVAL TECHNOLOGIES LIMITED | 58 |
| ULTIMA CHEMICALS | 58 |
| ANJI BIOSCIENCES | 58 |
| Vardhaman P Golechha | 58 |
| SYNOVA CHEMICALS | 58 |
| AMINO ORGANICS | 58 |
| SRF Limited | 58 |
| JSK Chemicals | 58 |
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