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ChemicalBook >> CAS DataBase List >>DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE

DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE

DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE Structure
DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE structure
CAS No.
632-93-9
Chemical Name:
DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE
Synonyms
Dicarbethoxydihydrocollidine;1,4-Dihydro-3,5-dicarbethoxycollidine;3,5-dicarbethoxy-1,4-dihydrocollidine;3,5-diethoxycarbonyl-1,4-dihydrocollidine;3,5-dicarbethoxy-1,4-dihydrocollidine, DDC;3,5-Bis(ethoxycarbonyl)-1,4-dihydrocollidine;3,5-DIETHOXYCARBONYL-1,4-DIHYDRO-2,4,6-COLLIDINE;Diethyl 1,4-dihydro-s-collidine-3,5-dicarboxylate;3,5-DICARBETHOXY-1,4-DIHYDRO-2,4,6-TRIMETHYLPYRIDINE;3,5-Diethoxycarbonyl-1,4-dihydro-2,4,6-collidine >
CBNumber:
CB7373477
Molecular Formula:
C14H21NO4
Molecular Weight:
267.32
MDL Number:
MFCD00005950
MOL File:
632-93-9.mol
MSDS File:
SDS
Last updated:2024-12-18 14:08:57
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DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE Properties

Melting point 130-132 °C(lit.)
Boiling point 410.51°C (rough estimate)
Density 1.1116 (rough estimate)
refractive index 1.5280 (estimate)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMF: 30 mg/ml; DMF:PBS (pH 7.2); (1:7): 0.125 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml
form powder to crystal
pka 3.53±0.70(Predicted)
color White to Orange to Green
CAS DataBase Reference 632-93-9(CAS DataBase Reference)
EPA Substance Registry System 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,4,6-trimethyl-, diethyl ester (632-93-9)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-37/39
WGK Germany  3
RTECS  US7979375
HS Code  2933.39.9200
NFPA 704
1
2 0

DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 137030 Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate 99% 632-93-9 25g $172 2024-03-01 Buy
TCI Chemical D0558 3,5-Diethoxycarbonyl-1,4-dihydro-2,4,6-collidine >98.0%(GC) 632-93-9 1g $16 2024-03-01 Buy
TCI Chemical D0558 3,5-Diethoxycarbonyl-1,4-dihydro-2,4,6-collidine >98.0%(GC) 632-93-9 5g $29 2024-03-01 Buy
Cayman Chemical 23230 Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate ≥98% 632-93-9 10g $37 2024-03-01 Buy
Cayman Chemical 23230 Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate ≥98% 632-93-9 25g $77 2024-03-01 Buy
Product number Packaging Price Buy
137030 25g $172 Buy
D0558 1g $16 Buy
D0558 5g $29 Buy
23230 10g $37 Buy
23230 25g $77 Buy

DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE Chemical Properties,Uses,Production

Description

Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate (DDC) inhibits heme production by inhibiting ferrochelatase, the enzyme that catalyzes the addition of Fe2+ to protoporphyrin IX to create heme B. Chronic DDC administration induces Mallory-Denk body formation, a feature of alcoholic and non-alcoholic hepatitis, and reduces IL-12A methylation in mouse liver.

Chemical Properties

almost white crystalline powder

Uses

Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate was used to induce Mallory-Denk body formation in mice in vivo.

Definition

ChEBI: A dihydropyridine that is 2,4,6-trimethyl-1,4-dihydropyridine substituted by ethoxycarbonyl groups at positions 3 and 5.

Biochem/physiol Actions

Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate blocks the heme synthesis and prevents the induction of hepatic heme oxygenase-1 in mice.

Purification Methods

Crystallise the ester from hot EtOH/water mixture. [Beilstein 22 H 147, 22 I 529, 22 II 100, 22 III/IV 1594.]

DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE Suppliers

Global( 92)Suppliers
Supplier Tel Email Country ProdList Advantage
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22963 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
ANHUI WITOP BIOTECH CO., LTD 		+8615255079626 eric@witopchemical.com China 23541 58
Shaanxi Dideu Medichem Co. Ltd 		+86-029-89586680 +86-18192503167 1026@dideu.com China 7724 58
LEAP CHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 24727 58
Jilin Chinese Academy of Sciences-yanshen Technology 		+undefined18143011203 info@chemextension.com China 42056 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
Mainchem Co., Ltd. +86-0592-6210733 sale@mainchem.com China 32343 55
Supplier Advantage
Hubei xin bonus chemical co. LTD 		58
Chongqing Chemdad Co., Ltd 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
ANHUI WITOP BIOTECH CO., LTD 		58
Shaanxi Dideu Medichem Co. Ltd 		58
LEAP CHEM CO., LTD. 		58
Jilin Chinese Academy of Sciences-yanshen Technology 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58
Mainchem Co., Ltd. 55

View Lastest Price from DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE pictures 2024-04-17 DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE
632-93-9
 US $1.10 / g 1g 99.0% min 100 tons min Shaanxi Dideu Medichem Co. Ltd
3,5-Dicarbethoxy-1,4-dihydro-2,4,6-trimethylpyridine pictures 2022-02-22 3,5-Dicarbethoxy-1,4-dihydro-2,4,6-trimethylpyridine
632-93-9
 US $0.00 / KG 1KG 97.8% 100 tons Honest Joy Holdings Limited

DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE Spectrum

DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE(632-93-9)MSDIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE(632-93-9)1HNMRDIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE(632-93-9)IR1DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE(632-93-9)IR2DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE(632-93-9)Raman

632-93-9(DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE)Related Search:

Diethyl pyridine-3,5-dicarboxylate DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE Nimodipine 3,5-Pyridinedicarboxylic acid 2,4,6-Collidine
3,5-PYRIDINEDICARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-4-(3,4,5-TRIMETHOXYPHENYL)-, DIETHYL ESTER 2,6-DIMETHYL-1,4-DIHYDRO-PYRIDINE-3,4,5-TRICARBOXYLIC ACID 3,5-DIETHYL ESTER DIETHYL 1,4-DIHYDRO-2,6-DIMETHYL-4-(4-F& DIETHYL 4-ETHYL-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLATE Diethyl2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate
2,6-Dimethyl-4-(2-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester AURORA 3177 LABOTEST-BB LT00261244 AURORA 3480 diethyl 2,6-dimethyl-4-thiophen-2-yl-1,4-dihydropyridine-3,5-dicarboxylate
DIETHYL 1,4-DIHYDRO-2,6-DIMETHYL-1,4-DIPHENYL-3,5-PYRIDINEDICARBOXYLATE AURORA 4028 3,5-PYRIDINEDICARBOXYLIC ACID, 4-(1,3-BENZODIOXOL-5-YL)-1,4-DIHYDRO-2,6-DIMETHYL-, DIETHYL ESTER

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DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYLPYRIDINE-3,5-DICARBOXYLATE 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER 3,5-DICARBETHOXY-1,4-DIHYDRO-2,4,6-TRIMETHYLPYRIDINE 3,5-DIETHOXYCARBONYL-1,4-DIHYDRO-2,4,6-COLLIDINE 5-pyridinedicarboxylicacid,1,4-dihydro-2,4,6-trimethyl-diethylester Dicarbethoxydihydrocollidine diethyl dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate 3,5-dicarbethoxy-1,4-dihydrocollidine, DDC 1,4-Dihydro-2,4,6-collidine-3,5-dicarboxylic acid diethyl ester 1,4-Dihydro-2,4,6-trimethylpyridine-3,5-dicarboxylic acid diethyl ester 1,4-Dihydro-3,5-dicarbethoxycollidine 3,5-Bis(ethoxycarbonyl)-1,4-dihydrocollidine Diethyl 1,4-dihydro-s-collidine-3,5-dicarboxylate Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate,99% 3,5-dicarbethoxy-1,4-dihydrocollidine Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate,3,5-dicarbethoxy-1,4-dihydrocollidine, DDC Diethyl 1,4-dihydro-2,4,6-triMethyl-3,5-pyridinedicarboxylate, 99% 25GR 1,4-Dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylic Acid Diethyl Ester Diethyl 1,4-Dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,4,6-triMethyl-, 3,5-diethyl ester Diethyl 1,4-dihydro-2,4,6-triMethyl-3,5-pyridinedicarboxylate 99% Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate 3,5-diethoxycarbonyl-1,4-dihydrocollidine DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE (4R)-2,4,6-trimethyl-3,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester 3,5-Diethoxycarbonyl-1,4-dihydro-2,4,6-collidine > DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE ISO 9001：2015 REACH 632-93-9 C14H21NO4 Building Blocks C9 to C46 Heterocyclic Building Blocks Pyridines