마니디핀
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마니디핀 속성
- 녹는점
- 125-128°C
- 끓는 점
- 722.0±60.0 °C(Predicted)
- 밀도
- 1.232±0.06 g/cm3(Predicted)
- 저장 조건
- Sealed in dry,2-8°C
- 용해도
- Soluble in DMSO > 10 mM
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 6.12±0.10(Predicted)
- LogP
- 4.135
마니디핀 C화학적 특성, 용도, 생산
개요
Manidipine is a dihydropyridine L- and T-type calcium channel blocker. It blocks recombinant rabbit L-type (α1Cα2/δβ1a) and human T-type (α1H) calcium channels expressed in Xenopus oocytes and native L-type channels in dissociated guinea pig cardiac ventricular cells (IC50 = 2.6 nM). Manidipine inhibits intracellular calcium increases induced by endothelin-1 (ET-1; ) in A7r5 rat vascular smooth muscle cells (ED50 = 1 nM) and potassium-induced contraction of isolated dog femoral and portal veins (IC50s = 24 and 2.1 nM, respectively). In vivo, it lowers blood pressure in spontaneously hypertensive rats (SHRs) when administered at a dose of 10 mg/kg and inhibits left ventricular hypertrophy in rats induced by isoproterenol when administered at a dose of 3 mg/kg. Formulations containing manidipine have been used in the treatment of hypertension.화학적 성질
Light Yellow Crystalline Solid용도
Manidipine (Manyper) is a lipophilic, third-generation, highly vasoselective dihydropyridine calcium antagonist with an IC50 of 2.6 nM. It causes systemic vasodilation by inhibiting the voltage-dependent calcium inward currents in smooth muscle cells. It마니디핀 준비 용품 및 원자재
원자재
Manidipine
아세틸 케텐
3-아미노크로톤산메틸
매니디핀염산염
1-(2-하이드록시에틸)피페라진
이소프로필에테르
황산마그네슘
2-(4-Benzhydrylpiperazino)ethyl acetoacetate
1,4-디하이드로-2,6-디메틸-4-(3-니트로페닐)-3,5-피리딘디카르복실산3-메틸에스테르
2-(4-벤즈히드릴피페라진-1-일)에탄올
Methyl 3-nitrobenzylideneacetoacetate
3-니트로벤즈알데히드
1-BENZHYDRYLPIPERAZINE
준비 용품
마니디핀 공급 업체
글로벌( 127)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49392 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
factory@coreychem.com | China | 29821 | 58 |
SIMAGCHEM CORP | +86-13806087780 |
sale@simagchem.com | China | 17367 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 |
1026@dideu.com | China | 7726 | 58 |
Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 |
gksales1@gk-bio.com | China | 9316 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6393 | 58 |
Shandong Zhishang New Material Co., Ltd. | +8617653113209 |
sales002@sdzschem.com | China | 3050 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 |
sales@tnjchem.com | China | 25363 | 58 |