ChemicalBook > Product Catalog >API >Circulatory system drugs >Calcium channel blockers >Cilnidipine
Cilnidipine
- CAS No.
- 132203-70-4
- Chemical Name:
- Cilnidipine
- Synonyms
- CiL;clinidipine;ATELEC;CINALONG;SISCARD;FRC-8653;FRG 8653;Sidipine;nidipine;ilnidipine
- CBNumber:
- CB2193117
- Molecular Formula:
- C27H28N2O7
- Molecular Weight:
- 492.52
- MOL File:
- 132203-70-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/8/4 0:20:14
| Melting point | 97-99°C |
|---|---|
| Boiling point | 652.6±55.0 °C(Predicted) |
| Density | 1.240±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | H2O: ≤2mg/mL |
| pka | 2.61±0.70(Predicted) |
| form | powder |
| color | light yellow |
| Merck | 14,2275 |
| InChIKey | KJEBULYHNRNJTE-DHZHZOJOSA-N |
| CAS DataBase Reference | 132203-70-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H318 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 41 | |||||||||
| Safety Statements | 26-39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | US7975550 | |||||||||
| HS Code | 29333990 | |||||||||
| Toxicity | LD50 in male, female mice, rats (mg/kg): 5000, 5000, 5000, 4412 orally; 5000 all species s.c.; 1845, 2353, 441, 426 i.p. (Wada) | |||||||||
| NFPA 704 |
|
Cilnidipine price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C1493 | Cilnidipine ≥98% (HPLC), powder | 132203-70-4 | 10MG | ₹16367.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C1493 | Cilnidipine ≥98% (HPLC), powder | 132203-70-4 | 50MG | ₹70135.18 | 2022-06-14 | Buy |
| TCI Chemicals (India) | C2564 | Cilnidipine | 132203-70-4 | 1G | ₹7900 | 2022-05-26 | Buy |
| TCI Chemicals (India) | C2564 | Cilnidipine | 132203-70-4 | 5G | ₹9800 | 2022-05-26 | Buy |
Cilnidipine Chemical Properties,Uses,Production
Description
Cilnidipine is a dihydropyridine calcium antagonist introduced for the treatment of essential and severe hypertension and hypertension associated with renopathy. Cilnidipine has been demonstrated to exert a potent vasodilating effect by blocking calcium influx via dihydropyridine-sensitive, voltage-dependent calcium channels. Compared to nifedipine and nicardipine, cilnidipine is superior, especially for long-term treatment, due to its characteristics of slow onset and long duration with less cardiodepressant activity. Cilnidipine is reportedly well tolerated with low toxicity. It may also be useful in ischemic heart disease.
Chemical Properties
Yellow Crystalline Solid
Uses
Cilnidipine has been used:
- in cell viability assay of pheochromocytoma (nPC12) cells
- in photoirradiation and photodegradation studies
- to understand effect on albuminuria in diabetic nephropathy
Definition
ChEBI: A diesterified 1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium channel blocker, it is used as an antihypertensive.
Biological Activity
Dual L- and N-type calcium channel blocker that displays antihypertensive, sympatholytic and neuroprotective activity. Lowers mean blood pressure and reduces the size of cerebral infarction in the rat model of focal brain ischemia.
Cilnidipine Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 472)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Laksh Finechem Pvt.Ltd. | +91-9978522233 +91-78522233 | Gujarat, India | 55 | 58 | Inquiry |
| Hetero Drugs Limited | +91-4023704923 +91-4023704923 | Telangana, India | 296 | 58 | Inquiry |
| Honour Lab Limited | +919845977466 | Telangana, India | 164 | 58 | Inquiry |
| Dayaram Pharma Chem | +91-9601766800 +91-9601766800 | Gujarat, India | 61 | 58 | Inquiry |
| Afton Pharma | +91-9712000202 +91-9712000202 | Gujarat, India | 63 | 58 | Inquiry |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | +91-26463395 +91-7926462688 | Gujarat, India | 1615 | 58 | Inquiry |
| J.B. Chemicals Pharmaceuticals Ltd. | +91-022-24822222 +91-02224822222 | Mumbai, India | 10 | 58 | Inquiry |
| JR Corporation | +91-9099076719 +91-7096568000 | Gujarat, India | 14 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Niksan Pharmaceutical | +91-9537871777 +91-9537871777 | Gujarat, India | 39 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Laksh Finechem Pvt.Ltd. | 58 |
| Hetero Drugs Limited | 58 |
| Honour Lab Limited | 58 |
| Dayaram Pharma Chem | 58 |
| Afton Pharma | 58 |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | 58 |
| J.B. Chemicals Pharmaceuticals Ltd. | 58 |
| JR Corporation | 58 |
| Ralington Pharma | 58 |
| Niksan Pharmaceutical | 58 |
132203-70-4(Cilnidipine)Related Search:
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(+/-)-(e)-cinnamyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
O3-(2-Methoxyethyl) O5-[(E)-3-phenylprop-2-enyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-(2-methoxyethyl)5-[(E)-3-phenyl-2-propenyl] ester
2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylic acid 3-(2-methoxyethyl)5-[(E)-3-phenyl-2-propenyl] ester
Frc 8653,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-Methoxyethyl (2E)-3-Phenyl-2-propenyl Ester
2-Methoxyethyl (2E)-3-Phenyl-2-propenyl 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
ilnidipine
3-CinnaMyl 5-(2-Methoxyethyl) 2,6-diMethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
3-Cinnamyl 5-(2-methoxyethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylat
1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID 2-METHOXYETHYL (2E)-3-PHENYL-2-PROPENYL ESTER
SISCARD
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-(2-methoxyethyl) 5-[(2E)-3-phenyl-2-propen-1-yl] ester
3-Cinnamyl 5-(2-methoxyethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxy
CILNIDIPINE
FRC-8653
CILNDIPINE
(e)-(+-)-ethoxyethyl3-phenyl-2-propenyleste
5-pyridinedicarboxylicacid,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-2-m
Cinildipine
CINILDPINE
Cinidipine
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-Methoxyethyl (2E)-3-Phenyl-2-propenyl Ester, FRC-8653, Atelec, Cinalong, Siscard,
CILNIDPINE
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 3-phenyl-2-propenyl ester, (E)-
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 3-phenyl-2-propenyl ester, (E)-(+-)-
FRG 8653
Cilnidipine and intermediates
2,6-dimethyl-4-(3-nitrophenyl)-5-(3-phenylprop-2-enoxymethyl)-1,4-dihydropyridine-3-carboxylic acid 2-methoxyethyl ester
Sidipine
Cilnidipine (FRC-8653)
Cilnidipine Whatsapp
Cilnidipine >
Cilnidipine RS
nidipine
2-Methoxyethyl (2E)-3-Phenyl-2-propenyl 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
Cilnidipine USP/EP/BP
CilnidipineQ: What is
Cilnidipine Q: What is the CAS Number of
Cilnidipine Q: What is the storage condition of
Cilnidipine
Cilnidipine D4
ATELEC
CINALONG
clinidipine
CiL
13C6]-Cilnidipine
Cilinidipine
Cilnidipine, ≥ 98.0%
132203-70-4
Dihydropyridine Class Chemicals
Intermediates & Fine Chemicals
Pharmaceuticals
Calcium channel
API
FRC 8653
Dihydropyridine
APIs
Active Pharmaceutical Ingredients
132203-70-4