2-Aminoethoxydiphenyl borate
- CAS No.
- 524-95-8
- Chemical Name:
- 2-Aminoethoxydiphenyl borate
- Synonyms
- 2-APB;NSC 17107;Natural Product;Naturstoffreagenz A;Diphenylborinic acid;NATURAL PRODUCT REAGENT A;AMINOETHOXYDIPHENYLBORANE;2-Aminoethyl diphenyl orate;2-AMINOETHOXYDIPHENYLBORATE;Aminoethyl Diphenylborinate
- CBNumber:
- CB3308983
- Molecular Formula:
- C14H16BNO
- Molecular Weight:
- 225.09
- MOL File:
- 524-95-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
| Melting point | 192-194 °C(lit.) |
|---|---|
| Boiling point | 325.3±34.0 °C(Predicted) |
| Density | 1.04±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in ethanol and methanol. |
| form | Liquid |
| pka | 8.03±0.10(Predicted) |
| color | Clear colorless to yellow |
| BRN | 2942273 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
| InChIKey | BLZVCIGGICSWIG-UHFFFAOYSA-N |
| CAS DataBase Reference | 524-95-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P302+P352-P305+P351+P338 | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | ED6150000 | |||||||||
| F | 8-21 | |||||||||
| HS Code | 29310099 | |||||||||
| NFPA 704 |
|
2-Aminoethoxydiphenyl borate price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | D9754 | 2-Aminoethyl diphenylborinate 97% | 524-95-8 | 1G | ₹3204.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D9754 | 2-Aminoethyl diphenylborinate 97% | 524-95-8 | 5G | ₹10272.93 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D9754 | 2-Aminoethyl diphenylborinate 97% | 524-95-8 | 10G | ₹18608.18 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D9754 | 2-Aminoethyl diphenylborinate 97% | 524-95-8 | 25G | ₹35581.78 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 100065 | 2-APB - CAS 524-95-8 - Calbiochem A cell-permeable modulator of Ins(1,4,5)P3-induced Ca2+ release. | 524-95-8 | 100MG | ₹10550.01 | 2022-06-14 | Buy |
2-Aminoethoxydiphenyl borate Chemical Properties,Uses,Production
Description
2-Aminoethyl diphenylborinate (2-APB) is a modulator of intracellular calcium levels and transient receptor potential (TRP) channels. It inhibits calcium release induced by inositol-1,4,5-triphosphate (IP3) in rat cerebellar microsomes (IC50 = 42 μM) without affecting IP3 binding to its receptor. 2-APB inhibits store-operated calcium entry (SOCE) in DT40 cells (IC50 = 4.8 μM), as well as inhibits TRP canonical 6 (TRPC6) and TRP melastatin 8 (TRPM8) and activates TRP vanilloid 1 (TRPV1), TRPV2, and TRPV3 in vitro. It also inhibits calcium transients induced by the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA) inhibitor thapsigargin in DDT1 MF-2 cells when used at a concentration of 75 μM. 2-APB inhibits differentiation of primary mouse brown adipocytes when used at concentrations ranging from 30 to 300 μM and reduces adipocyte triglyceride levels at 100 μM. It also increases the expression of Ucp1 and Pparg in primary mouse brown adipocytes. 2-APB (10 mg/kg) reduces protein levels of TRP melastatin 2 (TRPM2) in the rat hippocampus and improves learning and memory deficits induced by amyloid-β (25-35) in rats.
Chemical Properties
white crystalline powder
Uses
Ca release inhibitor, angiogensin II inhibitor
Definition
ChEBI: An organoboron compound that is diphenylborane in which the borane hydrogen is replaced by a 2-aminoethoxy group.
General Description
A cell-permeable modulator of Ins(1,4,5)P3-induced Ca2+ release. Inhibits Ins(1,4,5)P3-induced Ca2+ release from rat cerebellar microsomal preparations (IC50 = 42 μM) without affecting [3H]-Ins(1,4,5)P3 binding to its receptor. In liver cells, 2-APB inhibits store-operated Ca2+ channels through a mechanism which may involve its binding to either the channel protein or an associated regulatory protein. Has no effect on the Ca2+ release from the ryanodine-sensitive Ca2+ store prepared from rat leg skeletal muscle and heart.
Biological Activity
A functional and membrane permeable D-myo-inositol 1,4,5-trisphosphate (IP 3 ) receptor antagonist (IC 50 = 42 μ M). Stimulates store-operated calcium (SOC) release at low concentrations (< 10 μ M) and inhibits it at higher concentrations (up to 50 μ M). Increases STIM-Orai channel conductance and limits ion selectivity. Modulator of TRP channels; blocks TRPC1, TRPC3, TRPC5, TRPC6, TRPV6, TRPM3, TRPM7, TRPM8 and TRPP2 and at higher concentrations stimulates TRPV1, TRPV2 and TRPV3. Also blocks specific gap channel subtypes.
2-Aminoethoxydiphenyl borate Preparation Products And Raw materials
Raw materials
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| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| HiMedia Laboratories | 91-22-61471919 | Maharashtra, India | 1843 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | China | 16859 | 58 | Inquiry |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | China | 1807 | 55 | Inquiry |
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