morpholin-3-one
- CAS No.
- 109-11-5
- Chemical Name:
- morpholin-3-one
- Synonyms
- 3-MORPHOLINONE;3-Oxomorpholine;in-3-on;3-morpholone;JACS-109-11-5;Morpholin-3-on;MORPHOLIN-3-ONE;morpholine-3-one;3-Ketomorpholine;3-Morpholinone>
- CBNumber:
- CB2121662
- Molecular Formula:
- C4H7NO2
- Molecular Weight:
- 101.1
- MOL File:
- 109-11-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/7/27 17:31:07
| Melting point | 103.0 to 107.0 °C |
|---|---|
| Boiling point | 142°C/7mmHg(lit.) |
| Density | 1.122±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 14.37±0.20(Predicted) |
| color | White to Almost white |
| CAS DataBase Reference | 109-11-5(CAS DataBase Reference) |
| EPA Substance Registry System | 3-Morpholinone (109-11-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302+H312+H332-H315-H317-H318 |
| Precautionary statements | P280 |
| Safety Statements | 24/25 |
| HS Code | 29349990 |
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morpholin-3-one Chemical Properties,Uses,Production
Description
3-ketomorpholine is also known as morpholin-3-one. It is useful pharmacological intermediate. Recent studies have shown that some morpholin-3-one derivatives could effectively cause cell cycle arrest at G1 phase, increase the levels of P53 and Fas, and induce A549 cell apoptosis in lung cancer. This indicates it might be a useful tool for elucidating the molecular mechanism of lung cancer cell apoptosis and might also be potential anti-cancer drugs. Some of its derivatives have been proven to be useful for the prevention and treatment of arteriosclerosis and hypertriglyceridemia.
References
He, Q., et al. "Novel morpholin-3-one derivatives induced apoptosis and elevated the level of P53 and Fas in A549 lung cancer cells." Bioorganic & Medicinal Chemistry 15.11(2007): 3889.
Murai, Hiromu, et al. "Morpholinone derivatives and method of use." US, US4237132. 1980.
Gonzalez-garcia, Maria Rosario, and Fernandez, Maria Carmen. "Morpholinyl derivatives useful as MOGAT-2 inhibitors." (2015).
morpholin-3-one Preparation Products And Raw materials
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| GRK RESEARCH LABORATORIES PVT LTD | +91-8249607014 +91-9849401944 | Hyderabad, India | 205 | 58 | Inquiry |
| TANUJ PYRIDINE | 8790371027 | Hyderabad, India | 107 | 58 | Inquiry |
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| Manus Aktteva | +91 (79) 6512-3395 | New Delhi, India | 581 | 34 | Inquiry |
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| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| GRK RESEARCH LABORATORIES PVT LTD | 58 |
| TANUJ PYRIDINE | 58 |
| CHATURYA BIOTECH | 58 |
| Manus Aktteva | 34 |
| CHEMSWORTH | 30 |
| A.J Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Pharmaffiliates Analytics and Synthetics P. Ltd | 58 |
| SynZeal Research Pvt Ltd | 58 |
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