Dimethomorph
- CAS No.
- 110488-70-5
- Chemical Name:
- Dimethomorph
- Synonyms
- 4-(3-(4-chlorophenyl)-3-(3,4-dimethoxyphenyl)-1-oxo-2-propenyl)-morpholin (e,z)-4-[3-(4-chlorophenyl)-3-(3,4-dimethoxyphenyl)-1-oxo-2-propenyl]morpholine (e,z)-4-[3-(4-chlorophenyl)-3-(3,4-dimethoxyphenyl)acryloyl]morpholine 4-(3-(4-chlorophenyl)-3-(3,4-dimethoxyphenyl)-1-oxo-2-propenyl)morpholine;dimethomoph;Z-DIMETHOMORPH;3-(4-Chlorophenyl)-3-(3,4-diMethoxyphenyl)-1-Morpholinoprop-2-en-1-one;3-(4-Chlorophenyl)-3-(3,4-diMethoxyphenyl)-1-(4-Morpholinyl)-2-propen-1-one;FORUM;ACROBAT;CME 151;AcrobatWP;Festival C
- CBNumber:
- CB9774944
- Molecular Formula:
- C21H22ClNO4
- Molecular Weight:
- 387.86
- MOL File:
- 110488-70-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/9 21:58:15
| Melting point | 125-149°C |
|---|---|
| Boiling point | 584.9±50.0 °C(Predicted) |
| Density | 1.231±0.06 g/cm3(Predicted) |
| vapor pressure | 1 x 10-6 Pa (25 °C) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform: Soluble,Methanol: Soluble |
| pka | -1.19±0.20(Predicted) |
| Water Solubility | 50 mg l-1 (20-23 °C) |
| form | Solid |
| color | White to off-white |
| Merck | 13,3248 |
| BRN | 8794474 |
| LogP | 2.680 |
| EPA Substance Registry System | Dimethomorph (110488-70-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H360F-H411 |
| Precautionary statements | P202-P273-P280-P308+P313-P391-P405 |
| Hazard Codes | N |
| Risk Statements | 51/53 |
| Safety Statements | 61 |
| RIDADR | UN3077 9/PG 3 |
| WGK Germany | 2 |
| RTECS | QE0478300 |
| Toxicity | LD50 in rats (mg/kg): 321 i.p.; 3900 orally; >5000 dermally; LC50 (4-hr inhalation): >4.2 mg/ml (Veenstra, Owen) |
Dimethomorph Chemical Properties,Uses,Production
Description
Dimethomorph is a morpholine fungicide that inhibits fungal cell wall formation. It inhibits mycelial growth of the oomycete fungi P. citrophthora, P. parasitica, P. capsici, and P. infestans (EC50s = 0.14, 0.38, <0.1, and 0.16-0.3 μg/ml, respectively) but is less active against the green algae species C. vulgaris or S. obliquus in vitro (EC50s = 47.46 and 44.87 μg/ml, respectively). It inhibits androgen receptor (AR) activity in a reporter assay in MDA-kb2 human breast cancer cells but not in a yeast antiandrogen screen (IC20s = 0.263 and 38.5 μM, respectively). It is not toxic to rats (LD50 = 3,900 mg/kg) or goldfish (C. auratus; LC50 = >32 μg/ml).
Chemical Properties
Off-White Solid
Uses
Dimethomorph is a systemic fungicide which exhibits protectant, curative and antisporulant activities. It is active against fungal diseases such as leaf blight, downy mildew, damping off and foot-rot caused by Phytophthora spp. in/on grapes, potatoes and tomatoes.
Definition
ChEBI: A mixture of (E)- and (Z)-dimethomorph in an unspecified ratio. It is used as a systemic fungicide used on vines, potatoes, and greenhouse crops; only the Z isomer has fungicidal activity.
Agricultural Uses
Fungicide: A systemic fungicide that protects crops from mold. It also kills mold and prevents their spread; controls late blight on tomatoes; and is used as a wood preservative to control downey mildew.
Trade name
ACROBAT® WP; FORUM DC®, [manco- zeb + dimethomorph]; CME 151®; STATURE®
Metabolic pathway
Limited data are available in the open literature. Information presented in this summary is abstracted from the data evaluation published by the Pesticide Safety Directorate (PSD, 1994). Dimethomorph is a (1:l) mixture of the E- and Z-isomers. The Z-isomer has been shown to have all the intrinsic biological activities. The isomerisation of the E- and Z-isomers was observed when resolved isomers were exposed to UV light. Dimethomorph undergoes extensive degradation and metabolism in soil, plants and animals. The major metabolic pathway is the O-demethylation of one of the phenolic methoxy moieties to the corresponding phenols and conjugates. Other metabolic reactions include the oxidation of one of the CH2 moieties of the morpholine ring and the cleavage/opening of the morpholine ring (Scheme 1).
Dimethomorph Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| ENTOMIC CHEMICALS | +91-9425149263 +91-9425149263 | Madhya Pradesh, India | 39 | 58 | Inquiry |
| DHANVI EXIM SERVICES | +91-8790148237 +91-8790148237 | Hyderabad, India | 162 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| M/s Annapurna Traders | 08048610771 | Telangana, India | 2 | 58 | Inquiry |
| Excel Crop Care Limited | 08048361294Ext 955 | Mumbai, India | 5 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12460 | 58 | Inquiry |
| Qingdao Trust Agri Chemical Co.,Ltd | +8613573296305 | China | 213 | 58 | Inquiry |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | China | 2503 | 58 | Inquiry |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | China | 3002 | 58 | Inquiry |
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