Carmustine
- CAS No.
- 154-93-8
- Chemical Name:
- Carmustine
- Synonyms
- BCUN;BCNU;BICNU;BECENUN;sk27702;sri1720;fda0345;Gliadel;DTI 015;nitrumon
- CBNumber:
- CB0449612
- Molecular Formula:
- C5H9Cl2N3O2
- Molecular Weight:
- 214.05
- MOL File:
- 154-93-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/3/14 15:18:25
| Melting point | 30 °C (lit.) |
|---|---|
| Density | 1.6948 (rough estimate) |
| refractive index | 1.6100 (estimate) |
| storage temp. | -20°C |
| solubility | insoluble in H2O; ≥21.51 mg/mL in DMSO; ≥27.15 mg/mL in EtOH |
| form | (Oily liquid to amorphous solid) |
| pka | 10.19±0.46(Predicted) |
| color | Light-yellow powder |
| Water Solubility | <0.1 g/100 mL at 18 ºC |
| Merck | 14,1845 |
| Stability | Temperature Sensitive |
| InChIKey | DLGOEMSEDOSKAD-UHFFFAOYSA-N |
| CAS DataBase Reference | 154-93-8(CAS DataBase Reference) |
| IARC | 2A (Vol. 26, Sup 7) 1987 |
| EPA Substance Registry System | 1,3-Bis(2-chloroethyl)-1-nitrosourea (154-93-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300-H350-H360 | |||||||||
| Precautionary statements | P201-P280-P301+P330+P331+P310-P308+P313 | |||||||||
| Hazard Codes | T+ | |||||||||
| Risk Statements | 45-46-60-61-28 | |||||||||
| Safety Statements | 53-22-36/37/39-45 | |||||||||
| RIDADR | 3249 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | YS2625000 | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29241990 | |||||||||
| Toxicity | LD50 in mice (mg/kg): 19-25 orally, 26 i.p., 24 s.c.; in rats (mg/kg): 30-34 orally (Thompson, Larson) | |||||||||
| NFPA 704 |
|
Carmustine price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C0400 | Carmustine ≥98% | 154-93-8 | 25MG | ₹8356.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C0400 | Carmustine ≥98% | 154-93-8 | 100MG | ₹32345.1 | 2022-06-14 | Buy |
| TCI Chemicals (India) | C2634 | Carmustine | 154-93-8 | 100MG | ₹13200 | 2022-05-26 | Buy |
Carmustine Chemical Properties,Uses,Production
Description
Carmustine is a nitrogen mustard β-chloro-nitrosourea compound that is used as an alkylating agent. It forms interstrand crosslinks in DNA, which prevents DNA replication and transcription leading to apoptosis. Carmustine is also reported to inhibit glutathione reductase, thioredoxin reductase, and lipoamide dehydrogenase. Carmustine has been tested in clinical trials as a cytostatic agent for Hodgkin’s and non-Hodgkin’s lymphoma, myeloma, malignant melanoma, glioblastoma, and other brain tumors.
Chemical Properties
Carmustine is an orange-yellow crystalline solid or powder.
Uses
Carmustine is a nitrogen mustard β-chloro-nitrosourea compound that is used as an alkylating agent. It forms interstrand crosslinks in DNA, which prevents DNA replication and transcription leading to apoptosis. Carmustine is also reported to inhibit glutathione reductase, thioredoxin reductase, and lipoamide dehydrogenase. Carmustine has been tested in clinical trials as a cytostatic agent for Hodgkin’s and non-Hodgkin’s lymphoma, myeloma, malignant melanoma, glioblastoma, and other brain tumors.
Definition
ChEBI: A member of the class of N-nitrosoureas that is 1,3-bis(2-chloroethyl)urea in which one of the nitrogens is substituted by a nitroso group.
General Description
Orange-yellow solid.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Carmustin decomposes rapidly in acid and in solutions above pH 7; most stable in petroleum ether or aqueous solution at pH 4.
Hazard
Extremely toxic, central nervous system depression, pulmonary fibrosis, renal and hepatic damage, cytotoxic, immunosuppressive, carcino- gen.
Fire Hazard
Flash point data for Carmustin are not available. Carmustin is probably combustible.
Safety Profile
Confirmed carcinogen withexperimental carcinogenic and tumorigenic data. A humanpoison by parenteral route. An experimental poison byingestion, intravenous, intraperitoneal, parenteral, andsubcutaneous routes. Human systemic effects byparenteral, int
Potential Exposure
BCNU has been used since 1971 as an antineoplastic agent in the treatment of Hodgkin’slymphoma; multiple meyloma; and primary or metastatic brain tumors. It also has been reported to have antiviral, antibacterial, and antifungal activity, but no evidence was found that it is used in these ways. BCNU is not known to be naturally occurring. Health professionals who handle this drug (for example, pharmacists, nurses, and physicians) may possibly be exposed to BCNU during drug preparation, administration, or cleanup; however, the risks can be avoided through use of containment equipment and proper work practices
Carcinogenicity
Bis(chloroethyl) nitrosourea (BCNU) is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
Environmental Fate
It is generally assumed that BCNU exerts its cytotoxicity through the liberation of alkylating and carbamoylating moieties. An alkylating entity, particularly chloroethyl carbonium ion, is strongly electrophilic and can alkylate a variety of biomolecules, including the purine and pyrimidine bases of DNA. BCNU causes DNA interstrand cross-linking, which is associated with cytotoxicity. The carbamoylation of lysine residues of protein can inactivate certain enzymes, thus interfering with DNA and RNA synthesis and repair processes. The inhibition of glutathione reductase by this carbamoylation further contributes to cytotoxicity.
Shipping
UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1- Poisonous materials, Technical Name Required.
Incompatibilities
Acids and acid solutions above pH 7 cause rapid decomposition. Most stable at pH 4 in aqueous solution or petroleum ether.
Waste Disposal
It is inappropriate and possibly dangerous to the environment to dispose of expired or waste pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.
Carmustine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Jigs Chemical ltd | +919099003427 | Gujarat, India | 239 | 58 | Inquiry |
| Acura Life Sciences | +917780672646 | Hyderabad, India | 37 | 58 | Inquiry |
| AVD pharmaceuticals Pvt Ltd | +919860835260 | Pune, India | 102 | 58 | Inquiry |
| Vannsh Life Sciences Pvt Ltd | +91-4023555246 +91-9642555246 | Hyderabad, India | 15 | 58 | Inquiry |
| Shilpa Medicare Limited (SML) | +91-8532238704 +91-9320649838 | Karnataka, India | 61 | 58 | Inquiry |
| Apothecon Pharmaceuticals Pvt Ltd | +91-2662244212 +91-9099007601 | Gujarat, India | 28 | 58 | Inquiry |
| Basil Drugs AND Pharmaceuticals Pvt Ltd | +91-2249700250 +91-9619320820 | Mumbai, India | 108 | 58 | Inquiry |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | +91-26463395 +91-7926462688 | Gujarat, India | 1615 | 58 | Inquiry |
| NATCO Pharma Limited | +91-9849511345 +91-9866005199 | Hyderabad, India | 24 | 58 | Inquiry |
| Sakar Healthcare | +91-8976292690 +91-9967572302 | Gujarat, India | 47 | 58 | Inquiry |
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