Carmofur
- CAS No.
- 61422-45-5
- Chemical Name:
- Carmofur
- Synonyms
- hcfu;HCFUTM;Mifurol;CARMOFUR;Carmofur >Carmofur Carmofur;Carmofur, ≥ 98.0%;Carmofur USP/EP/BP;5-FLUORO-1-HEXYLCARBAMOYLURACIL;1-hexylcarbamoyl-5-fluorouracil
- CBNumber:
- CB5748051
- Molecular Formula:
- C11H16FN3O3
- Molecular Weight:
- 257.26
- MOL File:
- 61422-45-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/9/4 16:42:00
| Melting point | 110-111 |
|---|---|
| Density | 1.2287 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO: >15mg/mL |
| form | powder |
| pka | 6.94±0.10(Predicted) |
| color | white to off-white |
| Merck | 14,1844 |
| CAS DataBase Reference | 61422-45-5(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H361 | |||||||||
| Precautionary statements | P201-P301+P310+P330 | |||||||||
| Hazard Codes | Xi,T | |||||||||
| Risk Statements | 60-61-25 | |||||||||
| Safety Statements | 45 | |||||||||
| RIDADR | UN 2811 6.1 / PGII | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UV7714000 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29335990 | |||||||||
| NFPA 704 |
|
Carmofur price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C1494 | Carmofur ≥98% (HPLC), powder | 61422-45-5 | 10MG | ₹9601.78 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C1494 | Carmofur ≥98% (HPLC), powder | 61422-45-5 | 50MG | ₹38829.28 | 2022-06-14 | Buy |
| TCI Chemicals (India) | C2663 | Carmofur | 61422-45-5 | 5G | ₹14200 | 2022-05-26 | Buy |
Carmofur Chemical Properties,Uses,Production
Description
Carmofur is an inhibitor of acid ceramidase (IC50 = 79 nM for the rat enzyme) and a derivative of 5-flurouracil . It reduces acid ceramidase activity in a dose- and time-dependent manner and induces intracellular accumulation of various ceramide species, including C18 ceramide , C16 ceramide , and C14 ceramide in SW403 colon and LNCaP prostate cancer cells. Carmofur induces apoptosis in SW403 cells without inhibiting DNA synthesis (IC50 = 1,212 mM for human thymidylate synthetase). It also reduces acid ceramidase activity and increases ceramide accumulation in mouse lung and brain when administered at doses of 10 and 30 mg/kg.
Uses
Carmofur has been used as an inhibitor of acid ceramidase to study its effects on glucosylsphingosine (GlcSph) production in human embryonic kidney 293T (HEK293T) cells. It has also been used as an inhibitor of acid ceramidase to study its effects on acid‐mediated hydrolysis of ceramide which kicks-in consumption and the generation of sphingosine .
Carmofur Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | China | 6387 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | China | 34571 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 26415 | 58 | Inquiry |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | China | 15395 | 58 | Inquiry |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | China | 9327 | 58 | Inquiry |