ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Proteases >Gamma-secretase inhibitors >DAPT
DAPT
- CAS No.
- 208255-80-5
- Chemical Name:
- DAPT
- Synonyms
- DAPT (GSI-IX);GSI-IX;CS-175;AN-37124;SC-201315;DAPT DAPT;DAPT, >=98%;GSI-IX; GSI IX;EZSolution DAPT;Synonyms GSI-IX
- CBNumber:
- CB3503380
- Molecular Formula:
- C23H26F2N2O4
- Molecular Weight:
- 432.46
- MOL File:
- 208255-80-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/1/27 9:38:02
| alpha | +40.0～+47.0°(D/20℃)(c=0.5,DMSO) |
|---|---|
| Boiling point | 612.2±55.0 °C(Predicted) |
| Density | 1.213 |
| storage temp. | 2-8°C |
| solubility | DMSO: ~18 mg/mL |
| form | solid |
| pka | 12.82±0.46(Predicted) |
| color | white |
| biological source | synthetic (organic) |
| Sensitive | Light Sensitive |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| InChIKey | DWJXYEABWRJFSP-XOBRGWDASA-N |
| CAS DataBase Reference | 208255-80-5 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319 |
| Precautionary statements | P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330 |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| HS Code | 29242990 |
DAPT price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | D5942 | DAPT ≥98% (HPLC), solid | 208255-80-5 | 5MG | ₹18932.93 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D5942 | DAPT ≥98% (HPLC), solid | 208255-80-5 | 25MG | ₹85225.23 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 565770 | γ-Secretase Inhibitor IX - CAS 208255-80-5 - Calbiochem Gamma-Secretase Inhibitor IX - CAS 208255-80-5, is a cell-permeable inhibitor of γ-secretase (Aβtotal IC?? = 115 nM, Aβ42 IC?? = 200 nM). | 208255-80-5 | 5MG | ₹17969.99 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 565770 | γ-Secretase Inhibitor IX - CAS 208255-80-5 - Calbiochem Gamma-Secretase Inhibitor IX - CAS 208255-80-5, is a cell-permeable inhibitor of γ-secretase (Aβtotal IC?? = 115 nM, Aβ42 IC?? = 200 nM). | 208255-80-5 | 10MG | ₹25950 | 2022-06-14 | Buy |
| TCI Chemicals (India) | D4257 | DAPT | 208255-80-5 | 25MG | ₹18700 | 2022-05-26 | Buy |
DAPT Chemical Properties,Uses,Production
Uses
DAPT (GSI-IX) is a novel γ-secretase inhibitor, which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells
Biological Activity
Inhibitor of γ -secretase; causes a reduction in A β 40 and A β 42 levels in human primary neuronal cultures (IC 50 values are 115 and 200 nM for total A β and A β 42 respectively) and in brain extract, cerebrospinal fluid and plasma in vivo . Does not effect APP α and APP β levels. Blocks Notch signaling in hybrid human-mouse foetal thymus organ culture (FTOC). Activity causes neural cells to commit to neuronal differentiation.
Biochem/physiol Actions
DAPT is a γ-secretase inhibitor and indirectly an inhibitor of Notch, a γ-secretase substrate. Other γ-secretase substrates include LDL receptor-related protein, E-cadherin and ErbB-4. As an inhibitor of γ-secretase, DAPT may be useful in the study of β-amyloid (Aβ) formation. DAPT has been shown to inhibit Notch signaling in studies of autoimmune and lymphoproliferative diseases, such as ALPS and lupus erythematosus (SLE), as well as in cancer cell growth, angiogenesis, and differentiation of human induced pluripotent stem cells (hIPSC).
DAPT Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 241)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6768 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6905 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6100 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | China | 29730 | 60 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 33024 | 60 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19552 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49732 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29808 | 58 | Inquiry |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | China | 12226 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 32239 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Alfa Aesar | 58 |
| A.J Chemicals | 58 |
| Capot Chemical Co.,Ltd. | 60 |
| ATK CHEMICAL COMPANY LIMITED | 60 |
| BOC Sciences | 58 |
| CONIER CHEM AND PHARMA LIMITED | 58 |
| career henan chemical co | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | 58 |
| TargetMol Chemicals Inc. | 58 |
208255-80-5(DAPT)Related Search:
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LY-374973, N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester
N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethylester
SC-201315
(2S)-N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-2-phenylglycine tert-butyl ester
DAPT (enzyme inhibitor)
GSI-IX
γ-Secretase Inhibitor IX
tert-butyl (2R)-[((2S)-2-{[(3,5-difluorophenyl)acetyl]aMino}propanoyl)aMino](phenyl)ethanoate
Glycine, N-[(3,5-difluorophenyl)acetyl]-L-alanyl-2-phenyl-,1,1-diMethylethyl ester, (2S)-
(S)-tert-butyl 2-((S)-2-(2-(3,5-difluorophenyl)acetamido)propanamido)-2-phenylacetate
2S)-N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-2-phenylglycine tert-butyl ester DAPT (enzyme inhibitor)
DAPT
DAPT (enzyme inhibitor)
Synonyms GSI-IX
EZSolution DAPT
DAPT, >=98%
(3,5-Difluorophenylacetyl)-L-alanyl-L-2-phenylglycine tert-Butyl Ester
SC-201315 DAPT
tert-butyl (S)-2-((S)-2-(2-(3,5-difluorophenyl)acetamido)propanamido)-2-phenylacetate
Glycine, N-[2-(3,5-difluorophenyl)acetyl]-L-alanyl-2-phenyl-, 1,1-dimethylethyl ester, (2S)-
N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethyl ester(DAPT)
(2S)-N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenylglycine 1,1-dimethylethyl ester
GSI-IX; GSI IX
CS-175
γ-Secretase Inhibitor IX - CAS 208255-80-5 - Calbiochem
tert-butyl (2S)-2-[[(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoyl]amino]-2-phenylacetate
one of γ-Secretase inhibitor
N-(3-((3aS,7aS)-6-amino-3,3a,4,7a-tetrahydro-1H-thiopyrano[3,4-c]furan-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide
DAPT, 98%, a γ-secretase inhibitor
γ-Secretase Inhibitor DAPT
GSI-IX;GSI IX;LY-374973
DAPT DAPT
N-[2-(3,5-Difluorophenyl)acetyl]-L-alanyl-L-(2-phenyl)glycine tert-butyl ester
γ-Secretase Inhibitor DBZ
DAPT (GSI-IX, LY-374973)
DAPT (GSI-IX)
N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,2-dimethylethyl ester(DAPT)
γ-Secretase Inhibitor IX DAPT
AN-37124
LY-374973|||GSI-IX
DAPT, gamma-Secretase inhibitor
DAPT, 10 mM in DMSO
γ-Secretase Inhibitor IX
(3,5-Difluorophenylacetyl)-Ala-Phg-OtBu (5 mg vial)
208255-80-5
C23H26F2N2O4
C23H26O4N2F2
GSI-IX
Inhibitor
Angiogenesis and Metastasis
Protease inhibitor
Inhibitors