ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Proteases >Proteasome inhibitors >MG-132
MG-132
- CAS No.
- 133407-82-6
- Chemical Name:
- MG-132
- Synonyms
- CS-216;MG-132;Z-LL-CHO;Z-LLL-al;Z-LLL-CHO;(S)-MG132;MG-132(SSS);MG132/MG-132;MG-132, >=98%;Z-LEU-LEU-LEU-H
- CBNumber:
- CB3298042
- Molecular Formula:
- C26H41N3O5
- Molecular Weight:
- 475.62
- MOL File:
- 133407-82-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
| Melting point | 80-84℃ (DEC.) |
|---|---|
| alpha | -61～-67° |
| Boiling point | 682.0±55.0 °C(Predicted) |
| Density | 1.073 |
| Flash point | 366℃ |
| storage temp. | -20°C |
| solubility | methanol: 1 mg/mL |
| form | solid film |
| pka | 11.14±0.46(Predicted) |
| color | White |
| Water Solubility | Soluble in ethanol, chloroform, methanol, water. |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO, DMF or ethanol may be stored at -20° for up to 1 week. |
| InChIKey | TZYWCYJVHRLUCT-VABKMULXSA-N |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P271-P280 |
| Risk Statements | 36/37/38 |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| HS Code | 29242990 |
MG-132 price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 474790 | MG-132 - CAS 133407-82-6 - Calbiochem A cell-permeable, potent, reversible proteasome inhibitor (Ki = 4 nM). | 133407-82-6 | 1MG | ₹6600.01 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 474791 | InSolution MG-132 - CAS 133407-82-6 - Calbiochem InSolution MG-132, CAS 133407-82-6, is provided as a 10 mM solution in DMSO. Acts as a potent, reversible proteasome inhibitor (Ki = 4 nM). | 133407-82-6 | 1MG | ₹8890 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C2211 | Z-Leu-Leu-Leu-al ≥90% (HPLC) | 133407-82-6 | 5MG | ₹18175.18 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 474791 | InSolution MG-132 - CAS 133407-82-6 - Calbiochem InSolution MG-132, CAS 133407-82-6, is provided as a 10 mM solution in DMSO. Acts as a potent, reversible proteasome inhibitor (Ki = 4 nM). | 133407-82-6 | 5MG | ₹23839.99 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 474790 | MG-132 - CAS 133407-82-6 - Calbiochem A cell-permeable, potent, reversible proteasome inhibitor (Ki = 4 nM). | 133407-82-6 | 5MG | ₹17760.01 | 2022-06-14 | Buy |
MG-132 Chemical Properties,Uses,Production
Uses
A proteasome and NF-κB inhibitor.
Definition
ChEBI: A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.
General Description
Potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) and inhibits NF-κB activation (IC50 = 3 μM).
Biological Activity
Potent cell-permeable inhibitor of proteasome (IC 50 = 100 nM) and calpain (IC 50 = 1.2 μ M). Inhibits TNF- α -induced NF- κ B activation and I κ B α degradation. Induces neurite outgrowth in PC12 cells and has anticancer properties in vitro .
MG-132 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 292)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Alpha Biopharmaceuticals Co., Ltd | +86-15542445688 | China | 888 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21669 | 55 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | China | 10318 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| Hebei Yanxi Chemical Co., Ltd. | +86-17531190177; +8617531190177 | China | 5959 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
133407-82-6(MG-132)Related Search:
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PROTEASOME INHIBITOR MG-132
N-[(PHENYLMETHOXY)CARBONYL]-L-LEUCYL-N-[(1S)-1-FORMYL-3-METHYLBUTYL]-L-LEUCINAMIDE
N-CBZ-LEU-LEU-LEUCINAL
Z-LLL-CHO
Z-LL-CHO
Z-LEU-LEU-LEU-CHO
Z-LEU-LEU-LEU-H
Z-LEU-LEU-LEU-H (ALDEHYDE)
Z-LEU-LEU-LEU-ALDEHYDE
Z-LEU-LEU-ALDEHYDE
N-cbz-leu-leu-leu-al
z-leu-leu-leu-al
CALPAIN INHIBITOR IV
CARBOBENZOXY-L-LEUCYL-L-LEUCYL-LEUCINAL
CARBOBENZOXY-L-LEUCYL-L-LEUCYL-L-LEUCINAL
BENZYLOXYCARBONYL-L-LEUCYL-L-LEUCYL-L-LEUCINAL
benzyloxycarbonylleucyl-leucyl-leucinealdehyde
(S)-MG132
N-carbobenzyloxy-Leu-Leu-Leu-al
MG-132;Z-LEU-LEU-LEU-AL
Z-Leu-Leu-Leu-al,MG132
Calpain inhibitor IV-2
L-LeucinaMide, N-[(phenylMethoxy)carbonyl]-L-leucyl-N-[(1S)-1-forMyl-3-Methylbutyl]-
MG132/MG-132
MG-132 [Z-Leu-Leu-Leu-CHO]
Z-LEU-LEU-LEU-AL, >=90% (HPLC)
Benzyl (S)-4-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylami
InSolution? MG-132
MG-132, ≥95% by HPLC
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal
benzyl ((S)-4-Methyl-1-(((S)-4-Methyl-1-(((S)-4-Methyl-1-oxopentan-2-yl)aMino)-1-oxopentan-2-yl)aMino)-1-oxopentan-2-yl)carbaMate
MG 132
Calpain inhibitor IV-2
N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide Calpain inhibitor IV-2 MG 132
MG-132, >=98%
MG 132;MG132;Z-LEU-LEU-LEU-CHO;CARBOBENZOXY-L-LEUCYL-L-LEUCYL-L-LEUCINAL
MG132, 98%, proteasome inhibitor
CS-216
MG-132 - CAS 133407-82-6 - Calbiochem
MG-132, ≥95% by HPLC - CAS 133407-82-6 - Calbiochem
InSolution MG-132 - CAS 133407-82-6 - Calbiochem
benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate
Z-LLL-al
133407-82-6 MG-132 C26H41N3O5
MG-132
MG-132,Inhibitor,MG132,MG 132,complex,peptide,calpain,Autophagy,proteolytic,Proteasome,aldehyde,inhibit,Apoptosis,26S
MG-132 solution (10mM/L)
MG-132(SSS)
MG-132 (Ethanol Solution)
(S)-2-(Cbz-amino)-4-methyl-N-[(S)-4-methyl-1-[[(S)-4-methyl-1-oxo-2-pentyl]amino]-1-oxo-2-pentyl]pentanamide
133407-82-6
C26H41N3O5
Cell Signaling Enzymes
BioChemical
Biochemicals and Reagents
Application Index
Enzymes, Inhibitors, and Substrates
Proteasome, Calpain and Lysosomal Proteases
Proteasomes