ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Proteases >Cysteine ??Protease Inhibitors >Calpain Inhibitor I
Calpain Inhibitor I
- CAS No.
- 110044-82-1
- Chemical Name:
- Calpain Inhibitor I
- Synonyms
- ALLN;LLNL;MG 101;ac-llnl-cho;MG-101 (ALLN);InSolution? ALLN;Ac-Leu-Leu-Nle-al;AC-LL-NORLEUCINAL;CALPAIN INHIBITOR;AC-LEU-LEU-NLE-CHO
- CBNumber:
- CB6108214
- Molecular Formula:
- C20H37N3O4
- Molecular Weight:
- 383.53
- MOL File:
- 110044-82-1.mol
- Modify Date:
- 2023/5/18 11:31:10
| Melting point | 182 °C |
|---|---|
| Boiling point | 510.42°C (rough estimate) |
| Density | 1.1322 (rough estimate) |
| refractive index | 1.6300 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble |
| form | powder |
| pka | 13.53±0.46(Predicted) |
| color | white |
| Water Solubility | Soluble in dimethyl sulfoxide, ethanol, methanol. Insoluble in water, and aqueous buffers. |
| BRN | 7656053 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P271-P280 |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| F | 3-10 |
| HS Code | 29241900 |
Calpain Inhibitor I price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | A6185 | Calpain Inhibitor I ≥97% (TLC), powder | 110044-82-1 | 5MG | ₹12838.45 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A6185 | Calpain Inhibitor I ≥97% (TLC), powder | 110044-82-1 | 25MG | ₹42867 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 208719 | ALLN - CAS 110044-82-1 - Calbiochem Cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). | 110044-82-1 | 5MG | ₹10970.01 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 208750 | InSolution ALLN - CAS 110044-82-1 - Calbiochem | 110044-82-1 | 5MG | ₹11880 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 208719 | ALLN - CAS 110044-82-1 - Calbiochem Cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). | 110044-82-1 | 25MG | ₹23839.99 | 2022-06-14 | Buy |
Calpain Inhibitor I Chemical Properties,Uses,Production
Chemical Properties
white to off-white powder
Uses
It inhibits apoptosis in thymocytes and metamyelocytes. It also inhibits cell cycle progression at the G1/S border and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. ALLN inhibits the proteolysis of IκBα and IκBβ by the ubiquitin-proteasome complex. ALLN also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene.
Definition
ChEBI: A tripeptide composed of N-acetylleucyl, leucyl and norleucinal residues joined in sequence.
General Description
Calpain Inhibitor I is a strong, competitive inhibitor of the Ca2+-dependent neutral cysteine proteases calpain I and calpain II.
Biological Activity
Calpain inhibitor (IC 50 = 0.09 μ M) that activates p53-dependent apoptosis in tumor cell lines. Increases activated p53, p21 and caspase levels and promotes cell cycle arrest through inhibition of cyclin D degradation in vitro . Also attenuates ischemia/reperfusion injury in cardiomyocytes, hepatocytes and renal tubular cells through downregulation of iNOS and COX-2 expression.
Calpain Inhibitor I Preparation Products And Raw materials
Raw materials
Preparation Products
Calpain Inhibitor I Suppliers
Global( 115)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | China | 23556 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
| Wuhan Han Sheng New Material Technology Co.，Ltd | +8617798174412 | China | 2118 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 52927 | 58 | Inquiry |
| DONBOO AMINO ACID COMPANY | +8613063595538 | China | 9365 | 58 | Inquiry |
| Amadis Chemical Company Limited | 571-89925085 | China | 131980 | 58 | Inquiry |
110044-82-1(Calpain Inhibitor I)Related Search:
Calpain Inhibitor I
CALPAIN INHIBITOR I,CALPAIN INHIBITOR
CALPAIN INHIBITOR IV
CALPAIN INHIBITOR III
MET-ALA-GLY-ARG-SER-GLY-ASP-SER-ASP-GLU-ASP-LEU-LEU-LYS-ALA-VAL
(TYR0)-KALIURETIC PEPTIDE (HUMAN)
H-PRO-ALA-VAL-ASP-LEU-LEU-LYS-ASN-TYR-MET-GLN-LEU-GLY-LYS-GLN-OH
ASP-GLU-ASP-LEU-LEU-LYS-ALA-VAL-ARG-LEU-ILE-LYS-PHE-LEU-TYR-GLN-SER-ASN
PEPTITERGENT PD1
H-PRO-PRO-GLU-ASP-PRO-ALA-VAL-ASP-LEU-LEU-LYS-ASN-TYR-MET-GLN-LEU-GLY-LYS-GLN-GLN-OH
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AC-LEU-LEU-NLE-H (ALDEHYDE)
AC-LEU-LEU-NORLEUCINAL
AC-LL-NORLEUCINAL
ac-llnl-cho
Ac-Leu-Leu-Nle-al
Ac-LLnL-CHO, ALLN, MG-101, N-Acetyl-Leu-Leu-Norleu-al, N-Acetyl-L-leucyl-L-leucyl-L-norleucinal
Calpain Inhibitor I,96%
N-Acetyl-L-leucine-L-leucine-L-norleucinal
N-Acetyl-Leu-Leu-Norleu-al
Calpain Inhibitor I, ALLN
ALLN, Ac-LLnL-CHO, MG-101, N-Acetyl-Leu-Leu-Norleu-al, N-Acetyl-L-leucyl-L-leucyl-L-norleucinal
N-Acetyl-L-leucinyl-L-leucinyl-L-norleucinal
Calpain Inhibitor Ⅰ 〔N-Acetyl-L-leucyl-L-leucyl-L-norleucinal〕
InSolution? ALLN
MG-101 (ALLN)
N-acetyl-L-leucyl-N-[(1S)-1-formylpentyl]-L-Leucinamide
ALLN
acetylleucyl-leucyl-norleucinal
N-AC-LEU-LEU-NORLEUCINAL
N-ACETYL-LEU-LEU-NLE-CHO
N-ACETYL-L-LEUCYL-L-LEUCYL-L-NORLEUCINAL
N-ACETYL-LEU-LEU-NORLEUCINAL
MG 101
LLNL
CALPAIN INHIBITOR
CALPAIN INHIBITOR I
ACETYL-LEU-LEU-NORLEUCINAL
ACETYL-L-LEUCYL-L-LEUCYL-L-NORLEUCINAL
AC-LEU-LEU-L-NORLEUCINAL
AC-LEU-LEU-NLE-ALDEHYDE
AC-LEU-LEU-NLE-CHO
CALPAIN INHIBITOR I;AC-LLNL-CHO;ALLN
(S)-2-acetamido-N-((S)-1-amino-4-methyl-1-oxopentan-2-yl)-4-methyl-N-((S)-1-oxohexan-2-yl)pentanamide
L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-1-formylpentyl]-
MG-101 (Calpain inhibitor I
InSolution ALLN - CAS 110044-82-1 - Calbiochem
ALLN - CAS 110044-82-1 - Calbiochem
CALPAIN INHIBITOR-1;MG101;MG-101;MG 101
CALPAIN INHIBITOR I
RKO,MG-101,colon cancer,Bax,HepG2,Proteasome,MG 101,Inhibitor,mitochondria,HCT116,inhibit,Apoptosis,SW480,anti-tumor
N-Acetyl-Leu-Leu-Norleu-al, N-Acetyl-L-leucyl-L-leucyl-L-norleucinal
ALLN (DMSO solution)
110044-82-1
C20H37N3O4
Enzyme Inhibitors by Type
BioChemical
Biochemicals and Reagents
Calpain I
A to C
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Enzyme Inhibitors
Enzyme Inhibitors by Enzyme
Enzymes, Inhibitors, and Substrates
inhibitor
peptides
ProteasomeInhibitors
C-CH
Cell Biology