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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Proteases >Cysteine ??Protease Inhibitors >Calpain Inhibitor I

Calpain Inhibitor I

Calpain Inhibitor I Structure
  • ₹10970.01 - ₹42867
  • Product name: Calpain Inhibitor I
  • CAS: 110044-82-1
  • MF: C20H37N3O4
  • MW: 383.53
  • EINECS:999-999-2
  • MDL Number:MFCD00065505
  • Synonyms:AC-LEU-LEU-NLE-H (ALDEHYDE);AC-LEU-LEU-NORLEUCINAL;AC-LL-NORLEUCINAL;ac-llnl-cho;Ac-Leu-Leu-Nle-al;Ac-LLnL-CHO, ALLN, MG-101, N-Acetyl-Leu-Leu-Norleu-al, N-Acetyl-L-leucyl-L-leucyl-L-norleucinal;Calpain Inhibitor I,96%;N-Acetyl-L-leucine-L-leucine-L-norleucinal
Price5 Properties Safety Information Description
5 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product number208719
  • Product descriptionALLN - CAS 110044-82-1 - Calbiochem Cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM).
  • Packaging5MG
  • Price₹10970.01
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number208750
  • Product descriptionInSolution ALLN - CAS 110044-82-1 - Calbiochem
  • Packaging5MG
  • Price₹11880
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA6185
  • Product descriptionCalpain Inhibitor I ≥97% (TLC), powder
  • Packaging5MG
  • Price₹12838.45
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number208719
  • Product descriptionALLN - CAS 110044-82-1 - Calbiochem Cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM).
  • Packaging25MG
  • Price₹23839.99
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA6185
  • Product descriptionCalpain Inhibitor I ≥97% (TLC), powder
  • Packaging25MG
  • Price₹42867
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 208719 ALLN - CAS 110044-82-1 - Calbiochem Cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). 5MG ₹10970.01 2022-06-14 Buy
Sigma-Aldrich(India) 208750 InSolution ALLN - CAS 110044-82-1 - Calbiochem 5MG ₹11880 2022-06-14 Buy
Sigma-Aldrich(India) A6185 Calpain Inhibitor I ≥97% (TLC), powder 5MG ₹12838.45 2022-06-14 Buy
Sigma-Aldrich(India) 208719 ALLN - CAS 110044-82-1 - Calbiochem Cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). 25MG ₹23839.99 2022-06-14 Buy
Sigma-Aldrich(India) A6185 Calpain Inhibitor I ≥97% (TLC), powder 25MG ₹42867 2022-06-14 Buy

Properties

Melting point :182 °C
Boiling point :510.42°C (rough estimate)
Density :1.1322 (rough estimate)
refractive index :1.6300 (estimate)
storage temp. :2-8°C
solubility :DMSO: soluble
form :powder
pka :13.53±0.46(Predicted)
color :white
Water Solubility :Soluble in dimethyl sulfoxide, ethanol, methanol. Insoluble in water, and aqueous buffers.
BRN :7656053
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Description

Calpain inhibitor I is a synthetic tripeptide aldehyde that acts as a potent inhibitor of cysteine proteases including calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). At 10-100 μM calpain inhibitor I dose-dependently prevents the degradation of IκBα and IκBβ by the ubiquitin-proteasome complex, which blocks activation of NFκB and the production of TNF and IL-1β, suggesting a potential therapeutic effect for inflammatory diseases. At 10 μM, calpain inhibitor I can inhibit nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene.

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