Calpain Inhibitor I
- ₹10970.01 - ₹42867
- Product name: Calpain Inhibitor I
- CAS: 110044-82-1
- MF: C20H37N3O4
- MW: 383.53
- EINECS:999-999-2
- MDL Number:MFCD00065505
- Synonyms:AC-LEU-LEU-NLE-H (ALDEHYDE);AC-LEU-LEU-NORLEUCINAL;AC-LL-NORLEUCINAL;ac-llnl-cho;Ac-Leu-Leu-Nle-al;Ac-LLnL-CHO, ALLN, MG-101, N-Acetyl-Leu-Leu-Norleu-al, N-Acetyl-L-leucyl-L-leucyl-L-norleucinal;Calpain Inhibitor I,96%;N-Acetyl-L-leucine-L-leucine-L-norleucinal
5 prices
Selected condition:
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product number208719
- Product descriptionALLN - CAS 110044-82-1 - Calbiochem Cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM).
- Packaging5MG
- Price₹10970.01
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number208750
- Product descriptionInSolution ALLN - CAS 110044-82-1 - Calbiochem
- Packaging5MG
- Price₹11880
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberA6185
- Product descriptionCalpain Inhibitor I ≥97% (TLC), powder
- Packaging5MG
- Price₹12838.45
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number208719
- Product descriptionALLN - CAS 110044-82-1 - Calbiochem Cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM).
- Packaging25MG
- Price₹23839.99
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberA6185
- Product descriptionCalpain Inhibitor I ≥97% (TLC), powder
- Packaging25MG
- Price₹42867
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | 208719 | ALLN - CAS 110044-82-1 - Calbiochem Cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). | 5MG | ₹10970.01 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 208750 | InSolution ALLN - CAS 110044-82-1 - Calbiochem | 5MG | ₹11880 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | A6185 | Calpain Inhibitor I ≥97% (TLC), powder | 5MG | ₹12838.45 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 208719 | ALLN - CAS 110044-82-1 - Calbiochem Cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). | 25MG | ₹23839.99 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | A6185 | Calpain Inhibitor I ≥97% (TLC), powder | 25MG | ₹42867 | 2022-06-14 | Buy |
Properties
Melting point :182 °C
Boiling point :510.42°C (rough estimate)
Density :1.1322 (rough estimate)
refractive index :1.6300 (estimate)
storage temp. :2-8°C
solubility :DMSO: soluble
form :powder
pka :13.53±0.46(Predicted)
color :white
Water Solubility :Soluble in dimethyl sulfoxide, ethanol, methanol. Insoluble in water, and aqueous buffers.
BRN :7656053
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Boiling point :510.42°C (rough estimate)
Density :1.1322 (rough estimate)
refractive index :1.6300 (estimate)
storage temp. :2-8°C
solubility :DMSO: soluble
form :powder
pka :13.53±0.46(Predicted)
color :white
Water Solubility :Soluble in dimethyl sulfoxide, ethanol, methanol. Insoluble in water, and aqueous buffers.
BRN :7656053
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Safety Information
Symbol(GHS): | |||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Signal word: | Warning | ||||||||||||||||||||||||||||
Hazard statements: |
|
||||||||||||||||||||||||||||
Precautionary statements: |
|
Description
Calpain inhibitor I is a synthetic tripeptide aldehyde that acts as a potent inhibitor of cysteine proteases including calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). At 10-100 μM calpain inhibitor I dose-dependently prevents the degradation of IκBα and IκBβ by the ubiquitin-proteasome complex, which blocks activation of NFκB and the production of TNF and IL-1β, suggesting a potential therapeutic effect for inflammatory diseases. At 10 μM, calpain inhibitor I can inhibit nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene.More related product prices
CALPAIN INHIBITOR IIRelated product price
- CALPAIN INHIBITOR I
₹10970.01-42867 - MG-132
₹6600.01-40810 - CALPAIN INHIBITOR III
₹22009.99-25611.95