CALPAIN INHIBITOR III
- CAS No.
- 88191-84-8
- Chemical Name:
- CALPAIN INHIBITOR III
- Synonyms
- CS-1705;Calp III;MDL 28170;Z-Val-Phe-H;Z-VAL-PHE-CHO;4R)-Tofacitinib;Z-L-Val-L-Phe-OH;Z-VAL-PHE-ALDEHYDE;Cbz-L-Val-L-Phe-OH;CALPAIN INHIBITOR III
- CBNumber:
- CB3723465
- Molecular Formula:
- C22H26N2O4
- Molecular Weight:
- 382.45
- MOL File:
- 88191-84-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/18 11:31:19
| Boiling point | 595.6±50.0 °C(Predicted) |
|---|---|
| Density | 1.153±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 26 mg/mL |
| form | White lyophilized solid |
| pka | 11.05±0.46(Predicted) |
| color | White |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319-H335 |
| Precautionary statements | P260-P280-P301+P312 |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| HS Code | 2924297099 |
CALPAIN INHIBITOR III price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | M6690 | MDL 28170 ≥90% (TLC) | 88191-84-8 | 25MG | ₹25611.95 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 208722 | Calpain Inhibitor III - CAS 88191-84-8 - Calbiochem The Calpain Inhibitor III, also referenced under CAS 88191-84-8, controls the biological activity of Calpain. This small molecule/inhibitor is primari | 88191-84-8 | 25MG | ₹22009.99 | 2022-06-14 | Buy |
CALPAIN INHIBITOR III Chemical Properties,Uses,Production
Uses
MDL 28170 acts as a caplain inhibitor reducing hypoxia in ischemic-retinopathy, and various other neuroprotective effects.
Definition
ChEBI: A dipeptide resulting from the formal condensation of the carboxy group of N-benzyloxycarbonyl-L-valine with the amino group of L-phenylalanine aldehyde. It is a potent cell-permeable inhibitor of calpai I and II, and is also a gamma-secretase inhibitor.
General Description
A potent, cell-permeable inhibitor of calpain I and II (Ki = 8 nM) that also reduces capsaicin-mediated cell death in cultured dorsal root ganglion. Reported to block A23187-induced suppression of neurite outgrowth in isolated hippocampal pyramidal neurons. Exhibits neuroprotective effects against glutamate-induced toxicity.
Biological Activity
Potent, selective inhibitor of calpain and cathepsin B (K i values are 10 and 25 nM respectively) that does not inhibit trypsin-like serine proteases. Rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo .
CALPAIN INHIBITOR III Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Alpha Biopharmaceuticals Co., Ltd | +86-15542445688 | China | 888 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | China | 10326 | 58 | Inquiry |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | China | 23556 | 58 | Inquiry |
| BOC Sciences | 16314854226; +16314854226 | United States | 19743 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | China | 19915 | 58 | Inquiry |