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CALPAIN INHIBITOR III

CALPAIN INHIBITOR III Structure
  • ₹22009.99 - ₹25611.95
  • Product name: CALPAIN INHIBITOR III
  • CAS: 88191-84-8
  • MF: C22H26N2O4
  • MW: 382.45
  • EINECS:618-124-4
  • MDL Number:MFCD00798796
  • Synonyms:CALPAIN INHIBITOR III;CARBOBEZOXY-VALINYL-PHENYLALANINALZ-VAL-PHE-CHO;CARBOBENZOXY-VALINYL-PHENYLALANINAL;MDL 28170;Z-VAL-PHE-ALDEHYDE;Z-VAL-PHE-CHO;MDL 28170, Z-Val-Phe-al;Cbz-L-Val-L-Phe-OH
2 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product number208722
  • Product descriptionCalpain Inhibitor III - CAS 88191-84-8 - Calbiochem The Calpain Inhibitor III, also referenced under CAS 88191-84-8, controls the biological activity of Calpain. This small molecule/inhibitor is primari
  • Packaging25MG
  • Price₹22009.99
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberM6690
  • Product descriptionMDL 28170 ≥90% (TLC)
  • Packaging25MG
  • Price₹25611.95
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 208722 Calpain Inhibitor III - CAS 88191-84-8 - Calbiochem The Calpain Inhibitor III, also referenced under CAS 88191-84-8, controls the biological activity of Calpain. This small molecule/inhibitor is primari 25MG ₹22009.99 2022-06-14 Buy
Sigma-Aldrich(India) M6690 MDL 28170 ≥90% (TLC) 25MG ₹25611.95 2022-06-14 Buy

Properties

Boiling point :595.6±50.0 °C(Predicted)
Density :1.153±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: 26 mg/mL
form :White lyophilized solid
pka :11.05±0.46(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

Description

The calpains are a family of calcium-dependent cysteine proteases that catalyze limited proteolysis of substrates. Calpain Inhibitor III is a cell permeable, selective inhibitor of μ-calpain (calpain-1) and m-calpain (calpain-2). Calpain Inhibitor III crosses the blood-brain barrier to inhibit brain cysteine protease activity and has been reported to have neuroprotective effects in numerous rodent neurotrauma models, including spinal cord injury, cortical impact trauma, neonatal hypoxia-ischemia, and focal cerebral ischemia. Additionally, Calpain Inhibitor III has been shown to attenuate depression in myocardial contractile performance that occurs during reperfusion following cardiac ischemia.

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