Chinese english Japanese Germany Korea
ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Transmembrane Transporters >Sodium Channel Inhibitor >5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
-dimethoxyphenylamide

5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
-dimethoxyphenylamide

5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5<br>-dimethoxyphenylamide Structure
CAS No.
944261-79-4
Chemical Name:
5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
-dimethoxyphenylamide
Synonyms
brgt;CS-374;A 803467;[3H]-A-803467;A-803467, >98%;A-803467, >=99%;A803467;A 803467;-dimethoxyphenylamide;5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-;5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
CBNumber:
CB31471262
Molecular Formula:
C19H16ClNO4
Molecular Weight:
357.79
MOL File:
944261-79-4.mol
MSDS File:
SDS
Modify Date:
2023/7/12 18:09:44
Request For Quotation

5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
-dimethoxyphenylamide Properties

Melting point 128-130?C
Boiling point 450.6±45.0 °C(Predicted)
Density 1.294±0.06 g/cm3(Predicted)
storage temp. room temp
solubility DMSO: >10mg/mL
pka 11.72±0.70(Predicted)
form powder
color white to tan
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312a-P330-P501a
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3
NFPA 704
0
2 0

5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
-dimethoxyphenylamide price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) A3109 A-803467 ≥98% (HPLC) 944261-79-4 10MG ₹18186 2022-06-14 Buy
Sigma-Aldrich(India) A3109 A-803467 ≥98% (HPLC) 944261-79-4 50MG ₹70925.4 2022-06-14 Buy
Product number Packaging Price Buy
A3109 10MG ₹18186 Buy
A3109 50MG ₹70925.4 Buy

5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
-dimethoxyphenylamide Chemical Properties,Uses,Production

Description

Nav1.8 is a tetrodotoxin-resistant (TTX-R) sodium channel with high activation threshold and slow inactivating kinetics that is highly expressed in small-diameter sensory neurons and has been implicated in signaling various types of pain. A-803467 is a sodium channel blocker with high-affinity and selectivity for inhibiting human Nav1.8 sodium channels (IC50 = 8 nM when stimulated at half-maximal inactivation and IC50 = 79 nM at a resting state). This compound is unusual in that it blocks hNav1.8 at negative resting membrane potentials (many small molecule sodium channel blockers show a reduced affinity for the resting state) and does not demonstrate significant frequency-dependent block during a 10 Hz pulse train. A-803467 dose-dependently reduces behavioral responses in a variety of neuropathic and inflammatory pain models.

Chemical Properties

White Solid

General Description

The small molecule A-803467 is a potent and selective Nav1.8 sodium channel blocker. Nav1.8 is a tetrodotoxin-resistant (TTX-R) sodium channel that contributes to pain sensation by transmitting pain stimuli in peripheral sensory neurons; blockage of this channel by A-803467 reduces pain with varying effectiveness in a number of different models. A-803467 has been used to further understand the role of Nav1.8 in transmitting pain stimuli and also can be used as an analgesic.

Biological Activity

Selective blocker of Na V 1.8 channels (IC 50 values are 8, 2450, 6740, 7340 and 7380 nM for hNa V 1.8, hNa V 1.3, hNa V 1.7, hNa V 1.5 and hNa V 1.2 channels respectively). Shows no significant activity against TRPV1, P2X 2/3 , Ca V 2.2 and KCNQ2/3 channels. Antinociceptive; potently attenuates mechanical allodynia in two models of neuropathic pain following i.p. administration.

5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
-dimethoxyphenylamide Preparation Products And Raw materials

Raw materials

Preparation Products

5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
-dimethoxyphenylamide Suppliers

Global( 123)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Hangzhou FandaChem Co.,Ltd. 008657128800458; +8615858145714 China 9338 55 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29901 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 26216 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 China 11681 58 Inquiry
Supplier Advantage
A.J Chemicals 58
Hangzhou FandaChem Co.,Ltd. 55
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
CONIER CHEM AND PHARMA LIMITED 58
TargetMol Chemicals Inc. 58
Dideu Industries Group Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58

5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
-dimethoxyphenylamide Spectrum

5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
-dimethoxyphenylamide(944261-79-4)1HNMR

944261-79-4(5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
-dimethoxyphenylamide)Related Search:

Ranolazine dihydrochloride Tetracaine hydrochloride Aconitine VERATRIDINE TETRODOTOXIN
QX-314 L-KAWAIN BENZAMIL HYDROCHLORIDE Procainamide hydrochloride Linocaine hydrochloride
Bupivacaine Hydrochloride Lamotrigine N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride SDZ-201 106 (+/-) PD 85639
BATRACHOTOXIN A-803467 CHEMBRDG-BB 5929971
chevron_left

1of4

chevron_right
5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
-dimethoxyphenylamide 5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furancarboxamide A 803467 5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)- 5-4(-Chlorophenyl)-N-(3,5-diMethoxyphenyl)furan-2-carboxaMide 2-FurancarboxaMide,5-(4-chlorophenyl)-N-(3,5-diMethoxyphenyl)- 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5 A-803467, >=99% A803467;A 803467 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5lt brgt -dimethoxyphenylamide A-803467, >98% CS-374 [3H]-A-803467 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5-dimethoxyphenylamide USP/EP/BP 944261-79-4 Ion Channels Inhibitors Amines Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Sodium channel