TETRODOTOXIN
- CAS No.
- 4368-28-9
- Chemical Name:
- TETRODOTOXIN
- Synonyms
- TTX;bjt-1;tetrodoxin;TTX citrate;maculotoxin;spheroidine;FUGU POISON;tarichatoxin;TETRODOTOXIN;tetrodontoxin
- CBNumber:
- CB0489528
- Molecular Formula:
- C11H17N3O8
- Molecular Weight:
- 319.27
- MOL File:
- 4368-28-9.mol
- Modify Date:
- 2024/4/23 19:22:53
| Melting point | 280 °C (decomp) |
|---|---|
| alpha | D25 -8.64° (c = 8.55 in dil acetic acid) |
| Boiling point | 458.31°C (rough estimate) |
| Density | 1.3768 (rough estimate) |
| refractive index | 1.5700 (estimate) |
| storage temp. | 2-8°C |
| solubility | H2O: stable at pH 4-5 if stored frozensoluble |
| form | powder |
| pka | 8.76 (water); 9.4 (50% alc) |
| color | white |
| Merck | 13,9318 |
| Stability | Acid Sensitive, Hygroscopic |
| CAS DataBase Reference | 4368-28-9(CAS DataBase Reference) |
| EPA Substance Registry System | Tetrodotoxin (4368-28-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H330-H300-H310 | |||||||||
| Precautionary statements | P260-P271-P284-P304+P340-P310-P320-P403+P233-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501-P262-P264-P270-P280-P302+P350-P310-P322-P361-P363-P405-P501 | |||||||||
| Hazard Codes | T+ | |||||||||
| Risk Statements | 26/27/28 | |||||||||
| Safety Statements | 22-36/37/39-45-36/37-28 | |||||||||
| RIDADR | UN 3462 6.1/PG 1 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | IO1450000 | |||||||||
| F | 10-18 | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | I | |||||||||
| HS Code | 30029090 | |||||||||
| Toxicity | LD50 i.p. in mice: 10 mg/kg (Kao, Fuhrman) | |||||||||
| NFPA 704 |
|
TETRODOTOXIN Chemical Properties,Uses,Production
Description
Tetrodotoxin (TTX) is a selective sodium channel blocker nonprotein heat-stable toxin. The mechanism of toxicity is through the blockage of fast voltage-gated sodium channels. The consumption of toxic amounts of TTX results primarily in neurologic and gastrointestinal signs and symptoms. TTX is widely distributed in marine taxa such as pufferfish and porcupine fish (suborders of the Tetraodontiformes order), salamanders of the family Salamandridae, Central American frogs (genus Atelopus), shellfish, starfish, crabs, and some species of ribbonworm and octopus. However, in terrestrial taxa, it is limited to a single class of vertebrates (Amphibia). TTX is now known to be produced not by puffer but by bacteria, and reaches various species of animals via food chain.
Chemical Properties
white powder
Uses
Tetrodotoxin is a highly selective, reversible sodium channel blocker.
Definition
ChEBI: A quinazoline alkaloid that is a marine toxin isolated from fish such as puffer fish. It has been shown to exhibit potential neutotoxicity due to its ability to block voltage-gated sodium channels.
Biological Activity
Selective inhibitor of Na + channel conductance. Binding is reversible and of high affinity (K d = 1-10 nM). Blocks in a use-dependent manner.
Safety Profile
Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. When heated to decomposition it emits toxic fumes of Nox.
TETRODOTOXIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | China | 20308 | 58 | Inquiry |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | China | 9337 | 55 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | China | 34571 | 58 | Inquiry |
| Dorne Chemical Technology co. LTD | +86-86-13583358881 +8618560316533 | China | 3146 | 58 | Inquiry |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | China | 52861 | 58 | Inquiry |
| LEAP CHEM CO., LTD. | +86-852-30606658 | China | 24738 | 58 | Inquiry |
| PT CHEM GROUP LIMITED | +86-85511178 +86-85511178 | China | 35451 | 58 | Inquiry |
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | China | 19947 | 58 | Inquiry |
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