Chinese english Japanese Germany Korea

TETRODOTOXIN CITRATE

TETRODOTOXIN CITRATE Structure
CAS No.
18660-81-6
Chemical Name:
TETRODOTOXIN CITRATE
Synonyms
TETRODOTOXIN CITRATE;citratodetetrodotoxina;tetrodotoxin,citrate(1:1)(salt);Tetrodotoxin(TTX), with citrate;Citrato de tetrodotoxina [spanish];Tetrodotoxin, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (salt) (9ci);Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentolcitrat;OCTAHYDRO-12-(HYDROXYMETHYL)-2-IMINO-5,9:7,10A-DIMETHANO-10AH-[1,3]DIOXOCINO[6,5-D]PYRIMIDINE-4,7,10,11,12-PENTOL CITRATE;(5R,6R,7S,9R,11R,12R,13S,14S)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5,9,12,13,14-pentol 2-hydroxypropane-1,2,3-tricarboxylate (1:1) (non-preferred name)
CBNumber:
CB2192024
Molecular Formula:
C17H25N3O15
Molecular Weight:
511.39
MOL File:
18660-81-6.mol
Modify Date:
2025/4/24 21:50:42
Request For Quotation

TETRODOTOXIN CITRATE Properties

storage temp. Desiccate at -20°C
solubility Citrate Buffer (pH 4.8): 30 mg/ml (100 mM)
form A solid
pka 8.76(at 25℃)
Water Solubility Soluble to 100 mM in water
Stability Unstable in Acidic solution, Unstable In Acidic Solution

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H300-H330-H310
Precautionary statements  P260-P271-P284-P304+P340-P310-P320-P403+P233-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501-P262-P264-P270-P280-P302+P350-P310-P322-P361-P363-P405-P501
Hazard Codes  T+
Risk Statements  26/27/28
Safety Statements  22-36/37/39-45
RTECS  IO1450000
Toxicity A toxin contained in the ovary and liver of puffer fish, in the eggs of the California newt and in some other animals. It is used as a chemical tool for the study of ion channels. The s.c. LD50 in mice is 10 mg/kg. It is a toxicant of nerve and muscle by blocking sodium channels, this action causing nerve and muscle paralysis. Symptoms include weakening of voluntary muscles, respiratory failure from paralysis of the diaphragm and hypotension. There is no antidote. Therapy involves artificial respiration.
NFPA 704
0
4 0

TETRODOTOXIN CITRATE Chemical Properties,Uses,Production

Description

TTX is a potent marine-derived neurotoxin that reversibly inhibits the inward sodium current through voltage-activated sodium (Nav) channels, blocking nerve and muscle action potentials. It inhibits the Nav current in frog muscle and squid axon with IC50 values of 4.1 and 5.2 nM, respectively, and binds to rat brain membranes with a Kd value of 1.8 nM. TTX was used in Hodgkin and Huxley’s classic experiments to elucidate the physical biology of nerve action potentials and remains an indispensible neuroscience tool to pharmacologically dissect the contribution of the Nav current in excitable neurons and to rationally design compounds for the treatment of neuropathic pain. This citrate-stabilized form of TTX is designed for improved solubility over pure TTX , which is insoluble in water and most organic solvents. This preparation of TTX citrate consists of TTX that has been dissolved in a citrate solution and then lyophilized.

Biological Activity

Highly selective, reversible sodium channel blocker; citrate salt of tetrodotoxin.

TETRODOTOXIN CITRATE Preparation Products And Raw materials

Raw materials

Preparation Products

TETRODOTOXIN CITRATE Suppliers

Global( 46)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6257 58 Inquiry
Shaanxi Xianhe Biotech Co., Ltd +8617709210191 China 884 58 Inquiry
Dayang Chem (Hangzhou) Co.,Ltd. +86-0571-88938639 +8617705817739 China 52849 58 Inquiry
PT CHEM GROUP LIMITED +86-85511178; +86-85511178; China 35425 58 Inquiry
GIHI CHEMICALS CO.,LIMITED +8618058761490 China 49984 58 Inquiry
SUZHOU SENFEIDA CHEMICAL CO.,LTD +86-0512-83500002 +8618501500038 China 26362 58 Inquiry
LEAPCHEM CO., LTD. +86-852-30606658 China 43340 58 Inquiry
Cayman Chemical Company (800) 364-9897 United States 6213 81 Inquiry
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 China 11218 58 Inquiry
United States Biological 800.520.3011 or 781.639.5092 United States 6214 80 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
Shaanxi Xianhe Biotech Co., Ltd 58
Dayang Chem (Hangzhou) Co.,Ltd. 58
PT CHEM GROUP LIMITED 58
GIHI CHEMICALS CO.,LIMITED 58
SUZHOU SENFEIDA CHEMICAL CO.,LTD 58
LEAPCHEM CO., LTD. 58
Cayman Chemical Company 81
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
United States Biological 80

18660-81-6(TETRODOTOXIN CITRATE)Related Search:

ACONITINE TETRODOTOXIN-SENSITIV TETRODOTOXIN CITRATE (TETRAHYDRO-2H-PYRAN-3-YL)METHANAMINE HYDROCHLORIDE 2-(TETRAHYDRO-PYRAN-4-YL)-ETHANOL 1,4-Cyclohexanedimethanol
2-Amino-2-ethyl-1,3-propanediol TRANS-2-AMINOMETHYL-1-CYCLOHEXANOL TETRODOTOXIN BIS(3-AMINOPROPYL) ETHER 4-(2-AMINOETHYL)TETRAHYDROPYRAN
Ammonium citrate dibasic (TETRAHYDRO-2H-PYRAN-4-YL)METHANOL Ammonium citrate tribasic METHYL-(TETRAHYDRO-PYRAN-3-YLMETHYL)-AMINE 5,5-DIETHOXYPENTAN-1-OL
(4-AMINO-TETRAHYDRO-PYRAN-4-YL)-METHANOL TRANS-4-(METHYLAMINO)CYCLOHEXANOL CIS-2-METHYLAMINO-CYCLOHEXANOL
chevron_left

1of4

chevron_right
TETRODOTOXIN CITRATE OCTAHYDRO-12-(HYDROXYMETHYL)-2-IMINO-5,9:7,10A-DIMETHANO-10AH-[1,3]DIOXOCINO[6,5-D]PYRIMIDINE-4,7,10,11,12-PENTOL CITRATE citratodetetrodotoxina tetrodotoxin,citrate(1:1)(salt) Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentolcitrat Citrato de tetrodotoxina [spanish] Tetrodotoxin, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (salt) (9ci) Tetrodotoxin(TTX), with citrate (5R,6R,7S,9R,11R,12R,13S,14S)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5,9,12,13,14-pentol 2-hydroxypropane-1,2,3-tricarboxylate (1:1) (non-preferred name) 18660-81-6 C11H17N3O8C6H8O7 C17H25N3O15 Sodium channel