Procainamide hydrochloride
- CAS No.
- 614-39-1
- Chemical Name:
- Procainamide hydrochloride
- Synonyms
- PROCAINAMIDE HCL;Pronestyl;Procapan;Procanbid;Promide;Amisalin;amidoprocain;TIMTEC-BB SBB001067;promidehydrochloride;ProcainaMide HCl USP
- CBNumber:
- CB7139464
- Molecular Formula:
- C13H22ClN3O
- Molecular Weight:
- 271.79
- MOL File:
- 614-39-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/10/13 18:16:27
| Melting point | 165-168 °C |
|---|---|
| Density | 1.2027 (rough estimate) |
| refractive index | 1.6330 (estimate) |
| storage temp. | 2-8°C |
| solubility | H2O: soluble1g/10 mL, clear, greenish-yellow |
| form | Powder |
| color | White to slightly yellow |
| Water Solubility | soluble |
| Sensitive | Light Sensitive/Air Sensitive |
| Merck | 13,7845 |
| BRN | 3729517 |
| CAS DataBase Reference | 614-39-1(CAS DataBase Reference) |
| EPA Substance Registry System | Benzamide, 4-amino-N-[2-(diethylamino)ethyl]-, monohydrochloride (614-39-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | CV2295000 | |||||||||
| HS Code | 29242990 | |||||||||
| NFPA 704 |
|
Procainamide hydrochloride price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML2088 | Procainamide hydrochloride ≥98% (HPLC) | 614-39-1 | 250MG | ₹13390.53 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML2088 | Procainamide hydrochloride ≥98% (HPLC) | 614-39-1 | 1G | ₹53854.38 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1252 | Procainamide hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material | 614-39-1 | 500MG | ₹8107.93 | 2022-06-14 | Buy |
Procainamide hydrochloride Chemical Properties,Uses,Production
Description
Procainamide (hydrochloride) (Item No. 24359) is an analytical reference standard categorized as a local anesthetic. This product is intended for research and forensic applications.
Chemical Properties
White to slightly yellow powder
Uses
Procainamide hydrochloride (PAH) is suitable to investigate its binding behavior with human serum albumin and bovine serum albumin by fluorescence quenching study to understand the pharmacokinetic and pharmacodynamic mechanisms of PAH.
Definition
ChEBI: A hydrochloride which has procainamide as the amino component.
General Description
Procainamide hydrochloride,p-amino-N-[2-(diethylamino)ethyl]benzamidemonohydrochloride, procainamidium chloride (Pronestyl,Procan SR), has emerged as a major antiarrhythmic drug. Itwas developed in the course of research for compoundsstructurally similar to procaine, which had limited effectas an antiarrhythmic agent because of its central nervoussystem (CNS) side effects and short-lived action causedby rapid hydrolysis of its ester linkage by plasma esterases.Because of its amide structure, procainamide hydrochlorideis also more stable in water than is procaine. Aqueoussolutions of procainamide hydrochloride have a pH ofabout 5.5. A kinetic study of the acid-catalyzed hydrolysisof procainamide hydrochloride showed it to be unusuallystable to hydrolysis in the pH range 2 to 7, even at elevatedtemperatures.
Clinical Use
Procainamide hydrochloride is metabolized through theaction of N-acetyltransferase. The product of enzymaticmetabolism of procainamide hydrochloride is N-acetylprocainamide(NAPA), which possesses only 25% of the activityof the parent compound.26 A study of the disposition ofprocainamide hydrochloride showed that 50% of the drugwas excreted unchanged in the urine, with 7% to 24% recoveredas NAPA.28,29 Unlike quinidine, procainamide hydrochlorideis bound only minimally to plasma proteins.Between 75% and 95% of the drug is absorbed from the gastrointestinaltract. Plasma levels appear 20 to 30 minutesafter administration and peak in about 1 hour.30Procainamide hydrochloride appears to have all of theelectrophysiological effects of quinidine. It diminishesautomaticity, decreases conduction velocity, and increasesaction potential duration and, thereby, the refractory periodof myocardial tissue. Clinicians have favored the use of procainamidehydrochloride for ventricular tachycardias andquinidine for atrial arrhythmias, even though the two drugsare effective in either type of disorder.
Procainamide hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Gland Pharma Ltd | +91-7075736524 +91-9700602423 | Telangana, India | 44 | 58 | Inquiry |
| Biophore India Pharmaceuticals Pvt Ltd | +91-9100031592 +91-9030907714 | Telangana, India | 134 | 58 | Inquiry |
| BIOPHORE INDIA PHARMACEUTICALS PVT LTD | +91-4047474545 | New Delhi, India | 105 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| GLAND PHARMA LTD | +91-40-30510999 | New Delhi, India | 52 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12459 | 58 | Inquiry |
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