3-Aminophenol
- CAS No.
- 591-27-5
- Chemical Name:
- 3-Aminophenol
- Synonyms
- M-AMINOPHENOL;META AMINO PHENOL;m-Aminofenol;3-HYDROXYANILINE;1-Amino-3-hydroxybenzene;3-AMINO-1-HYDROXYBENZENE;nakoteg;renaleg;ursoleg;furroeg
- CBNumber:
- CB8853903
- Molecular Formula:
- C6H7NO
- Molecular Weight:
- 109.13
- MOL File:
- 591-27-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/5 7:33:04
| Melting point | 120-124 °C (lit.) |
|---|---|
| Boiling point | 164 °C/11 mmHg (lit.) |
| Density | 0.99 |
| vapor pressure | 0.019Pa at 20℃ |
| refractive index | 1.5444 (estimate) |
| Flash point | 155 °C |
| storage temp. | 2-8°C |
| solubility | 26g/l |
| Colour Index | 76545 |
| form | Crystalline Powder |
| pka | 4.37, 9.82(at 20℃) |
| color | White to pinkish or light gray |
| PH | 6.8 (10g/l, H2O, 20℃) |
| Odor | odorless |
| Water Solubility | 35 g/L (20 ºC) |
| Merck | 14,460 |
| BRN | 636059 |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents, bases, mineral acids. May be light or air-sensitive. |
| LogP | 0.183 at 20℃ |
| CAS DataBase Reference | 591-27-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Phenol, 3-amino-(591-27-5) |
| EPA Substance Registry System | 3-Aminophenol (591-27-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H332-H319-H411 | |||||||||
| Precautionary statements | P261-P264-P273-P301+P312-P304+P340+P312-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,N | |||||||||
| Risk Statements | 20/22-51/53 | |||||||||
| Safety Statements | 28-61-28A | |||||||||
| RIDADR | UN 2512 6.1/PG 3 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | SJ4900000 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29222900 | |||||||||
| Toxicity | LD50 i.p. in mice: 4.5 mg/20g (Koelzer, Giesen) | |||||||||
| NFPA 704 |
|
3-Aminophenol price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 8.00420 | 3-Aminophenol for synthesis | 591-27-5 | 5G | ₹3319.99 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.00420 | 3-Aminophenol for synthesis | 591-27-5 | 250G | ₹7720 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1225 | 3-Aminophenol Pharmaceutical Secondary Standard; Certified Reference Material | 591-27-5 | 500MG | ₹8346.08 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.00420 | 3-Aminophenol for synthesis | 591-27-5 | 1KG | ₹18350 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.00420 | 3-Aminophenol for synthesis | 591-27-5 | 50KG | ₹341800 | 2022-06-14 | Buy |
3-Aminophenol Chemical Properties,Uses,Production
Chemical Properties
Light grey crystal powder
Uses
3-Aminophenol is an aromatic compound used in the preparation of inhibitors of mammalian carbonic anhydrase isoforms. Also used in the preparation of quinoline tethered fluorescent carbon dots for regulated anticancer discovery.
Application
3-Aminophenol has been used in the synthesis of disulfonated bis[4-(3-aminophenoxy)phenyl]sulfone (S-BAPS).
It can be used to synthesize:
Methyl 2-oxo-7-[(triphenylphosphoranylidene)amino]-2H-chromene-4-carboxylate by reacting with dimethyl acetylenedicarboxylate (DMAD) in the presence of triphenylphosphine.
3-Amino-2-cyclohexen-1-one via palladium-catalyzed hydrogenation.
Definition
ChEBI: An aminophenol that is one of three amino derivatives of phenol which has the single amino substituent located meta to the phenolic -OH group.
General Description
White crystals or off-white flakes.
Air & Water Reactions
3-Aminophenol may be sensitive to prolonged exposure to air and light. Slightly soluble in water.
Reactivity Profile
3-Aminophenol may react with strong oxidizers and mineral acids or bases.
Hazard
Toxic by ingestion.
Fire Hazard
Flash point data for 3-Aminophenol are not available. 3-Aminophenol is probably combustible.
Safety Profile
Poison by ingestion, subcutaneous, and intraperitoneal routes. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. A skin and eye irritant. When heated to decomposition it emits toxic fumes of NOx,.
Potential Exposure
Workers may be exposed to oAminophenol during its use as a chemical intermediate; in the manufacture of azo and sulfur dyes; and in the photographic industry. There is potential for consumer exposure to o-Aminophenol because of its use in dyeing hair, fur, and leather. The compound is a constituent of 75 registered cosmetic products suggesting the potential for widespread consumer exposure. p-Aminophenol is used mainly as a dye, dye intermediate and as a photographic developer; and in small quantities in analgesic drug preparation. Consumer exposure to p-aminophenol may occur from use as a hairdye or as a component in cosmetic preparations. mAminophenol is used mainly as a dye intermediate
Shipping
UN2512 Aminophenols (o-; m-; p-), Hazard Class: 6.1; Labels: 6.1-Poisonous materials
Purification Methods
Crystallise it from hot water or toluene. [Beilstein 13 IV 952.]
Incompatibilities
These phenol/cresol materials can react with oxidizers; reaction may be violent. Incompatible with strong reducing substances such as alkali metals, hydrides, nitrides, and sulfides. Flammable gas (H2) may be generated, and the heat of the reaction may cause the gas to ignite and explode. Heat may be generated by the acidbase reaction with bases; such heating may initiate polymerization of the organic compound. Reacts with boranes, alkalies, aliphatic amines, amides, nitric acid, sulfuric acid. Phenols are sulfonated very readily (e.g., by concentrated sulfuric acid at room temperature). These reactions generate heat. Phenols are also nitrated very rapidly, even by dilute nitric acid and can explode when heated. Many phenols form metal salts that may be detonated by mild shock.
Waste Disposal
Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.
3-Aminophenol Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
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|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| ANJI BIOSCIENCES | +91-9000100077 +91-9000100077 | Hyderabad, India | 430 | 58 | Inquiry |
| sheetalchemicals | +91-9820130159 +91-9820130159 | Maharashtra, India | 77 | 58 | Inquiry |
| SRI HAIMAVATHI ORGANICS | +91-040-40030163 +91-9493978643 | Hyderabad, India | 21 | 58 | Inquiry |
| AnalyticsStanza Inc | +91-7032031309 +91-7032031309 | Hyderabad, India | 227 | 58 | Inquiry |
| Cefa-Cilinas Biotics Pvt Ltd | +91-7875033155 +91-8080701561 | Maharashtra, India | 121 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| KARPSCHEM LABORATORIES | +91-7249203006 +91-7249203006 | Maharashtra, India | 786 | 58 | Inquiry |
| Prolife Bio Chemical Industries Pvt Ltd | +91-9825114995 +91-9825114995 | Gujarat, India | 74 | 58 | Inquiry |
| Anubhav Business Corporation | +91-2228014519 +91-2228014999 | Maharashtra, India | 119 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| GLR Innovations | 58 |
| ANJI BIOSCIENCES | 58 |
| sheetalchemicals | 58 |
| SRI HAIMAVATHI ORGANICS | 58 |
| AnalyticsStanza Inc | 58 |
| Cefa-Cilinas Biotics Pvt Ltd | 58 |
| JSK Chemicals | 58 |
| KARPSCHEM LABORATORIES | 58 |
| Prolife Bio Chemical Industries Pvt Ltd | 58 |
| Anubhav Business Corporation | 58 |