Benoxinate Hydrochloride
- CAS No.
- 5987-82-6
- Chemical Name:
- Benoxinate Hydrochloride
- Synonyms
- β;D01768;novesin;Benoxil;lacrimin;cebesine;novesine;Novesina;dorsacaine;conjuncain
- CBNumber:
- CB1476374
- Molecular Formula:
- C17H29ClN2O3
- Molecular Weight:
- 344.88
- MOL File:
- 5987-82-6.mol
- Modify Date:
- 2024/7/26 15:15:06
| Melting point | 157-160 C |
|---|---|
| storage temp. | 2-8°C |
| solubility | Very soluble in water, freely soluble in ethanol (96 per cent). |
| form | Solid |
| color | White to Off-White |
| Merck | 13,1045 |
| InChI | InChI=1S/C17H28N2O3.ClH/c1-4-7-11-21-16-13-14(8-9-15(16)18)17(20)22-12-10-19(5-2)6-3;/h8-9,13H,4-7,10-12,18H2,1-3H3;1H |
| InChIKey | PRGUDWLMFLCODA-UHFFFAOYSA-N |
| SMILES | C1(C(=O)OCCN(CC)CC)=CC=C(N)C(OCCCC)=C1.Cl |
| CAS DataBase Reference | 5987-82-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P305+P351+P338-P261 |
| Hazard Codes | Xi,Xn |
| Risk Statements | 36/37/38-20/21/22 |
| Safety Statements | 22-26-36 |
| RIDADR | UN 1544PSN2 6.1 / PGIII |
| WGK Germany | 3 |
| RTECS | DG1502900 |
| HS Code | 29225000 |
| Toxicity | LD50 scu-rat: 60 mg/kg NIIRDN 6,154,82 |
Benoxinate Hydrochloride price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR2352 | Benoxinate Hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material | 5987-82-6 | 300MG | ₹22710.85 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | B9050 | Benoxinate hydrochloride meets USP testing specifications | 5987-82-6 | 5G | ₹20610.8 | 2022-06-14 | Buy |
Benoxinate Hydrochloride Chemical Properties,Uses,Production
Chemical Properties
White or almost white, crystalline powder or colourless crystals.
Uses
Benoxinate Hydrochloride is a local anesthetic used in ophthalmology to numb the surface of the eye for a variety of procedures.
Definition
ChEBI: The monohydrochloride salt of oxybuprocaine.
Clinical Use
Benoxinate hydrochloride is a topical anesthetic. Benoxinate hydrochloride ophthalmic solution, 0.4%, was originally permitted in 1953 as Dorsacaine under NDA 08-729. The product was reviewed as part of the Drug Efficacy Study Implementation (DESI), found to be effective, approved and marketed by Dorsey until 1980. An abbreviated new drug application (ANDA) was also approved [Sola Barnes Hind (ANDA 84-149)] and marketed until 1991.
Side effects
The most common ocular adverse events associated with Benoxinate Hydrochloride when used as an eye drop ingredient (Fluorescein and Benoxinate Ophthalmic Solution) were: stinging, burning and conjunctival redness. Serious adverse reactions include corneal toxicity and corneal damage due to insensitivity. Other possible side effects include eye congestion, burning, stinging, eye irritation, blurred vision and punctate keratitis.
Safety Profile
Poison by subcutaneous route. A topical anesthetic. When heated to decomposition it emits toxic fumes of NOx and HCl.
Benoxinate Hydrochloride Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
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|---|---|---|---|---|---|
| Alkaloids Private Limited | +91-9866110664 +91-9866110664 | Telangana, India | 25 | 58 | Inquiry |
| Sanvin Group of Companies (Pioneer Agro Industries) | +91-2261066638 +91-2261066600 | Maharashtra, India | 27 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Hebei Yanxi Chemical Co., Ltd. | +86-17531190177; +8617531190177 | China | 6010 | 58 | Inquiry |
| Hebei Guanlang Biotechnology Co,.LTD | +86-19930503253; +8619930503252 | China | 5835 | 58 | Inquiry |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | China | 2503 | 58 | Inquiry |
| Ouhuang Engineering Materials (Hubei) Co., Ltd | +86-86177 | China | 2952 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21670 | 55 | Inquiry |