Cinchocaine
- CAS No.
- 85-79-0
- Chemical Name:
- Cinchocaine
- Synonyms
- Dibucain;percamine;DIBUCAINE;INN / BAN;Dermacaine;Nupercaine;Nupercainal;CINCHOCAINE;Zinn cocaine;DIBUCAINE BASE
- CBNumber:
- CB1396856
- Molecular Formula:
- C20H29N3O2
- Molecular Weight:
- 343.46
- MOL File:
- 85-79-0.mol
- Modify Date:
- 2024/7/2 8:55:00
| Melting point | 64° |
|---|---|
| Boiling point | 478.73°C (rough estimate) |
| Density | 1.1145 (rough estimate) |
| refractive index | 1.6300 (estimate) |
| storage temp. | Store at -20°C |
| solubility | DMSO:45.0(Max Conc. mg/mL);131.02(Max Conc. mM) |
| pka | pKa -5.3(aq. H2SO4) (Uncertain) |
| form | Solid:particulate/powder |
| color | White to yellow |
| Water Solubility | 68.01mg/L(temperature not stated) |
| InChI | InChI=1S/C20H29N3O2/c1-4-7-14-25-19-15-17(16-10-8-9-11-18(16)22-19)20(24)21-12-13-23(5-2)6-3/h8-11,15H,4-7,12-14H2,1-3H3,(H,21,24) |
| InChIKey | PUFQVTATUTYEAL-UHFFFAOYSA-N |
| SMILES | N1C2C(=CC=CC=2)C(C(NCCN(CC)CC)=O)=CC=1OCCCC |
| LogP | 4.4 at 25℃ and pH7 |
| CAS DataBase Reference | 85-79-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Dibucaine(85-79-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H318 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501-P280-P305+P351+P338-P310 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-41 | |||||||||
| Safety Statements | 26-39 | |||||||||
| RTECS | GD3150000 | |||||||||
| NFPA 704 |
|
Cinchocaine Chemical Properties,Uses,Production
Uses
Cinchocaine is a local anesthesic,used for Na+ channel blocker.
Definition
ChEBI: A monocarboxylic acid amide that is the 2-(diethylamino)ethyl amide of 2-butoxyquinoline-4-carboxylic acid. One of the most potent and toxic of the long-acting local anesthetics, its parenteral use was restricted to spinal anesthesia. It is now generally o ly used (usually as the hydrochloride) in creams and ointments and in suppositories for temporary relief of pain and itching associated with skin and anorectal conditions.
General Description
Articaine has a secondary nitrogen with a pKa of 7.8. It containsan aromatic thiophene ring bioisostere of the phenylring found in most other amide anesthetics. The log P of abenzene ring is 2.13 and the thiophene ring log P is 1.81,thus the thiophene ring is more hydrophilic than a phenylring. Although the thiophene ring has less lipid solubilitythan a phenyl ring, articaine is a lipid-soluble compound dueto the propylamine, the branched methyl and the substitutionson the thiophene ring. The onset of action of articaineis similar to lidocaine’s onset of action.
Contact allergens
Dibucaine hydrochloride is an amide group local anesthetic that can induce allergic contact dermatitis.
Clinical Use
Articaine is availablein a 4% solution with epinephrine for use in infiltrationand nerve block anesthesia.Articaine is metabolized rapidly via plasma and tissuecarboxyesterase to its primary metabolite, the inactive,water-soluble carboxylic acid. Approximately 40% to 70%of articaine administered epidurally is metabolized to thecarboxylic acid, articainic acid. Approximately 4% to 15%of the articainic acid undergoes glucuronide conjugationand only 3% of the dose is recovered unchanged in theurine. The rapid plasma metabolism and reported inactivityof the carboxylic acid metabolite make articaine a potentiallysafer anesthetic agent when multiple or large dosesare necessary.
Cinchocaine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| MOLECRAFT LIFE SCIENCES PVT LTD | +91 9581188881 | Telangana, India | 189 | 58 | Inquiry |
| Anugraha Chemicals | +91-8041685494 +91-9845939733 | Karnataka, India | 22 | 58 | Inquiry |
| Chempifine Chemicals | +91-2225667766 +91-2225667766 | Punjab, India | 144 | 58 | Inquiry |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | +91-26463395 +91-7926462688 | Gujarat, India | 1615 | 58 | Inquiry |
| Sanvin Group of Companies (Pioneer Agro Industries) | +91-2261066638 +91-2261066600 | Maharashtra, India | 27 | 58 | Inquiry |
| AKASH PHARMA EXPORTS | +91-9388123451 +91-9846039283 | Kerela, India | 470 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Triveni Interchem Private Limited (Group Of Triveni... | 08046042087 | Gujarat, India | 497 | 58 | Inquiry |
| Xiamen Wonderful Bio Technology Co., Ltd. | +8613043004613 | China | 305 | 58 | Inquiry |
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